Continuing the quest for autoimmunity due to oral metal exposure

Rachmawati, Dessy; Muris, Joris; Scheper, Rik J.; Rustemeyer, Thomas; Kleverlaan, Cornelis J.; Feilzer, Albert J.; Blomberg, B. Mary E. von; Hoogstraten, Ingrid M.W. van

doi:10.3109/08916934.2015.1033688

Cited by 13 publications

(7 citation statements)

References 30 publications

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“…Furthermore, reactions to palladium are observed in about 50% of patients with an allergy to nickel [ 27 , 28 , 29 , 30 ]. In the study by Rachmawati et al, 80% of patients (25) with a positive test reaction to nickel also showed sensitization to palladium salts [ 31 ]. In the study by Raap et al, (2009), all patients (100%, 10) with nickel sensitization also showed a positive patch-test response to palladium [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

“…No thyroid antibodies were found on sensitization to palladium, gold and mercury. In contrast, thyroid antibodies were detected in patients with nickel sensitization [ 31 ]. In the study by Muris et al (2014), patients with palladium-containing dental alloys showed an increased epicutaneous test response and lymphocyte proliferation [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

“…An increase in hypothyroidism has also been described in the clinical picture of oral lichen planus and oral lichenoid lesions. In the study by Rachmawati et al (2015), there was an association between autoimmune diseases and sensitization to the dental metals nickel, palladium, gold, and mercury. No thyroid antibodies were found on sensitization to palladium, gold and mercury.…”

Section: Allergies and Systemic Diseasesmentioning

confidence: 99%

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Potential Co-Factors of an Intraoral Contact Allergy—A Cross-Sectional Study

2020

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The aim of this cross-sectional study was to evaluate the frequency of dental allergens and potential co-factors, especially hypothyroidism, for patients with an intraoral contact allergy. From 2015 to 2016, patients with confirmed symptoms of an intraoral contact allergy (study group SG n = 50) were recruited in the dental clinic of the University of Leipzig. The participants of the control group (CG n = 103) were patients without oral diseases or intraoral symptoms of a contact allergy. For the data collection, a new “Allergy questionnaire” was developed. Information on allergies and general diseases were collected. The statistical analysis was carried out with SPSS 23.0. Sensitizations/allergies to metals and composites were higher in SG compared to CG. Of all study participants (n = 148), 14.2% (n = 21) had a nickel allergy. In 18% (n = 8) of the SG a cobalt allergy based on all metal allergens could be seen. In addition, an association between a nickel and cobalt allergy was found. Hypothyroidism occurred significantly more frequently (p = 0.049) in SG than in CG. Sensitizations and allergies can occur to metals in dental alloys. Hypothyroidism increased the risk of having an allergy threefold.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Allergies and Systemic Diseasesmentioning

confidence: 99%

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Potential Co-Factors of an Intraoral Contact Allergy—A Cross-Sectional Study

2020

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“…50 % der Patienten mit einer Allergie auf Nickel wird auch oftmals eine Reaktion auf Palladium beobachtet [16 -19]. In der Untersuchung von Rachmawati et al wiesen sogar 80 % der Patienten (n = 25) mit positiver Testreaktion auf Nickel auch eine Sensibilisierung gegenüber Palladiumsalzen auf [20]. In der Studie von Raap et al (2009) zeigten alle Patienten (100%, n = 10) mit einer Nickelsensibilisierung auch eine positive Epikutantestreaktion auf Palladium [21].…”

Section: Vorkommen Von Kreuzallergienunclassified

Wechselwirkungen von Metallionen in der Mundhöhle

Olms¹,

Schnutenhaus²

2020

ZWR - Das Deutsche Zahnärzteblatt

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“…Exposure to metal ions in the oral cavity can cause adverse reactions, such as inflammatory effects, allergic reactions, and mutagenic effects, depending on the concentration of metal ions released. Immunotoxicity of dental alloy is largely due to the release of Ni 2+ ions, which can cause several local symptoms such as oral lichen(oid) lessions/oral lichen planus (OLL/OLP) to autoimmune disease (AID) and neurotoxicity [6].…”

Section: Introductionmentioning

confidence: 99%

Brewed Robusta Coffee Increases Nickel Ion Release from Dental Alloys: An In Vitro Study

et al. 2021

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Alloys in oral cavity always interact with dynamic oral environment, such as pH, temperature, salivary conditions, and dietary habits. Coffee can further decrease pH in the oral cavity. Thus, coffee may increase the release of metal ions that may lead to various health diseases. This study aimed to quantitively investigate the effect of brewed Robusta coffee on the nickel ion release and their morphological structures; Methods: 20 alloy specimens were divided into 4 groups and placed in solutions for 48 and 168 h: (1) distilled water, (2) artificial saliva, (3) Robusta coffee, and (4) mixture of artificial saliva and Robusta coffee. AAS, XRF, and SEM were used for examinations; Results: The release of Ni2+ was found in all groups and robust release were found in the coffee only and mixture of coffee + artificial saliva solution after 168 h. Likewise, SEM showed that internal oxidation was high after 168 h of immersion; Conclusions: The concentration of nickel increased in saliva of low pH due to brewed coffee. Though the release of these ions is still within the tolerable amount in human body, it should be realized that it usually lasts for months or years. Dentists should be cautious when using instructions for patients with a history of allergies especially for dietary with low acidity.

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Continuing the quest for autoimmunity due to oral metal exposure

Abstract: The results of this study support the view that development of metal contact allergies may prevent autoimmune activation, and, second, that oral exposure to Pd, Au or Hg does not facilitate the development of AID.

Cited by 13 publications

References 30 publications

Potential Co-Factors of an Intraoral Contact Allergy—A Cross-Sectional Study

Potential Co-Factors of an Intraoral Contact Allergy—A Cross-Sectional Study

Wechselwirkungen von Metallionen in der Mundhöhle

Brewed Robusta Coffee Increases Nickel Ion Release from Dental Alloys: An In Vitro Study

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