Continued Exposure to Maternal Distress in Early Life Is Associated with an Increased Risk of Childhood Asthma

Kozyrskyj, Anita L.; Mai, Xiao-Mei; McGrath, Patrick J.; HayGlass, Kent T.; Becker, Allan B.; MacNeil, Brian

doi:10.1164/rccm.200703-381oc

Cited by 163 publications

(170 citation statements)

References 37 publications

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“…This study found a highly significant effect of behavioural difficulties preceding the onset of parent-reported wheeze (OR 8.95). KOZYRSKYJ et al [17] used medical records to investigate the link between maternal depression and/or anxiety diagnosis and physician diagnosis of asthma in their children. At 7-year follow-up, the authors report a mildly significant effect (OR 1.25) with subsequent analyses revealing a dose-response relationship between intensity and severity of mental health difficulties and likelihood of asthma diagnosis.…”

Section: Parental Mental Health Difficulties and Asthma Onsetmentioning

confidence: 99%

Adverse childhood experience and asthma onset: a systematic review

2015

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Adverse childhood experiences such as abuse and neglect are associated with subsequent immune dysregulation. Some studies show an association between adverse childhood experiences and asthma onset, although significant disparity in results exists in the published literature.We aimed to review available studies employing a prospective design that investigates associations between adverse childhood experience and asthma. A search protocol was developed and studies were drawn from four electronic journal databases. Studies were selected in accordance with pre-set inclusion criteria and relevant data were extracted.12 studies, assessing data from a total of 31 524 individuals, were identified that investigate the impact of a range of adverse childhood experiences on the likelihood of developing asthma. Evidence suggests that chronic stress exposure and maternal distress in pregnancy operate synergistically with known triggers such as traffic-related air pollution to increase asthma risk.Chronic stress in early life is associated with an increased risk of asthma onset. There is evidence that adverse childhood experience increases the impact of traffic-related air pollution and inconsistent evidence that adverse childhood experience has an independent effect on asthma onset. @ERSpublications Chronic stress in early life is associated with an increased risk of asthma onset

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Section: Parental Mental Health Difficulties and Asthma Onsetmentioning

confidence: 99%

Adverse childhood experience and asthma onset: a systematic review

2015

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“…Maternal distress in early life may play a role in the development of childhood asthma, especially if the distress continues beyond the postpartum period 43 .…”

Section: Psychosocial Factorsmentioning

confidence: 99%

Global strategy for the diagnosis and management of asthma in children 5 years and younger

Pedersen

Hurd

Lemanske

et al. 2010

Pediatric Pulmonology

267

207

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Asthma is the most common chronic disease of childhood and the leading cause of childhood morbidity from chronic disease as measured by school absences, emergency department visits, and hospitalions1. During the past two decades, many scientific advances have improved our understanding of asthma and our ability to manage and control it effectively. However, in children 5 years and younger, the clinical symptoms of asthma are variable and non‐specific. Furthermore, neither airflow limitation nor airway inflammation, the main pathologic hallmarks of the condition, can be assessed routinely in this age group. For this reason, to aid in the diagnosis of asthma in young children, a symptoms‐only descriptive approach that includes the definition of various wheezing phenotypes has been recommended2. In 1993, the Global Initiative for Asthma (GINA) was implemented to develop a network of individuals, organizations, and public health officials to disseminate information about the care of patients with asthma while at the same time assuring a mechanism to incorporate the results of scientific investigations into asthma care. Since then, GINA has developed and regularly revised a Global Strategy for Asthma Management and Prevention. Publications based on the Global Strategy for Asthma Management and Prevention have been translated into many different languages to promote international collaboration and dissemination of information.In this report, Global Strategy for Asthma Management and Prevention in Children 5 Years and Younger, an effort has been made to present the special challenges that must be taken into account in managing asthma in children during the first 5 years of life, including difficulties with diagnosis, the efficacy and safety of drugs and drug delivery systems, and the lack of data on new therapies. Approaches to these issues will vary among populations in the world based on socioeconomic conditions, genetic diversity, cultural beliefs, and differences in healthcare access and delivery. Patients in this age group are often managed by pediatricians and general practitioners routinely faced with a wide variety of issues related to childhood diseases. Pediatr Pulmonol. 2011; 46:1–17. © 2010 Wiley‐Liss, Inc.

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“…Atopic asthma 3 20 n/a 23 n/a n/a n/a 23 Caucasian (79.2%); (2) the Study of Asthma Genes and Environment (SAGE) cohort (Kozyrskyj et al 2008;Mai et al 2007) composed of 723 children and their parents from Manitoba, Canada, who are primarily Caucasian (74.2%); (3) the Saguenay-Lac-Saint-Jean and Quebec City Familial Asthma Collection (SLSJ) (Begin et al 2007;Laitinen et al 2004;Laprise et al 2004;Poon et al 2004Poon et al , 2005Raby et al 2002;Tremblay et al 2006) consisting of a French-Canadian founder population panel of 306 multigenerational families with at least one asthmatic proband; and (4) The Busselton Health Study (Busselton) (James et al 2005a, b), a population-based, nested, case-control panel of 1,549 individuals of European Caucasian descent from Australia. Of note is that at the time of phenotyping, subjects in the CAPPS and SAGE panels were between the ages of 6 and 8 (birth cohorts), whereas subjects in the SLSJ and Busselton panels were primarily teenagers or adults.…”

Section: Study Samples (Panels)mentioning

confidence: 99%

Analyses of associations with asthma in four asthma population samples from Canada and Australia

et al. 2009

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Asthma, atopy, and related phenotypes are heterogeneous complex traits, with both genetic and environmental risk factors. Extensive research has been conducted and over hundred genes have been associated with asthma and atopy phenotypes, but many of these findings have failed to replicate in subsequent studies. To separate true associations from false positives, candidate genes need to be examined in large well-characterized samples, using standardized designs (genotyping, phenotyping and analysis). In an attempt to replicate previous associations we amalgamated the power and resources of four studies and genotyped 5,565 individuals to conduct a genetic association study of 93 previously associated candidate genes for asthma and related phenotypes using the same set of 861 single-nucleotide polymorphisms (SNPs), a common genotyping platform, and relatively harmonized phenotypes. We tested for association between SNPs and the dichotomous outcomes of asthma, atopy, atopic asthma, and airway hyperresponsiveness using a general allelic D. Daley and M. Lemire contributed equally to this manuscript. Electronic supplementary materialThe online version of this article

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Continued Exposure to Maternal Distress in Early Life Is Associated with an Increased Risk of Childhood Asthma

Abstract: Maternal distress in early life plays a role in the development of childhood asthma, especially if it continues beyond the postpartum period.

Cited by 163 publications

References 37 publications

Adverse childhood experience and asthma onset: a systematic review

Adverse childhood experience and asthma onset: a systematic review

Global strategy for the diagnosis and management of asthma in children 5 years and younger

Analyses of associations with asthma in four asthma population samples from Canada and Australia

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