Adverse childhood experience and asthma onset: a systematic review

Abstract

Adverse childhood experiences such as abuse and neglect are associated with subsequent immune dysregulation. Some studies show an association between adverse childhood experiences and asthma onset, although significant disparity in results exists in the published literature.We aimed to review available studies employing a prospective design that investigates associations between adverse childhood experience and asthma. A search protocol was developed and studies were drawn from four electronic journal databases. Studies were selected in accordance with pre-set inclusion criteria and relevant data were extracted.12 studies, assessing data from a total of 31 524 individuals, were identified that investigate the impact of a range of adverse childhood experiences on the likelihood of developing asthma. Evidence suggests that chronic stress exposure and maternal distress in pregnancy operate synergistically with known triggers such as traffic-related air pollution to increase asthma risk.Chronic stress in early life is associated with an increased risk of asthma onset. There is evidence that adverse childhood experience increases the impact of traffic-related air pollution and inconsistent evidence that adverse childhood experience has an independent effect on asthma onset. @ERSpublications Chronic stress in early life is associated with an increased risk of asthma onset

Intergenerational Associations of Parent Adverse Childhood Experiences and Child Health Outcomes

“…35 Our intergenerational findings for offspring health outcomes mirror existing research linking ACEs with poorer health in the same individuals, PEDIATRICS Volume 141, number 6, June 2018 5 including obesity and asthma. 1,2,5,36,37 ACEs have also been related to poor self-rated health status among adults, although this has not been the case in 2 recent studies of youth. 1,38,39 Pediatric research shows withinindividual associations between child ACE exposure and poorer physical, psychological, and developmental health.…”

Adverse Childhood Experiences (ACE) in outpatients with anxiety and depressive disorders and their association with psychiatric and somatic comorbidity and revictimization. Cross-sectional observational study

“…An association between childhood maltreatment and sexual revictimization in adult life was indeed established in general population studies for both women and men (Werner et al, 2016;Fergusson et al, 1997;Roodman and Clum, 2001;Desai et al, 2002;Filipas and Ullman, 2006). ACE seem to influence the immune system and to be associated with the onset of asthma in children (Exley et al, 2015). Other chronic medical conditions might be associated as well.…”

Childhood adversities and chronic conditions: examination of mediators, recall bias and age at diagnosis

“…In particular, there has been a great amount of research on how childhood socioeconomic status (CSES) and childhood abuse (CA) relate to chronic conditions in later life, and reviews have shown reasonable associations between these variables (Kalmakis and Chandler 2015;Pavalko and Caputo 2013;Spencer et al 2013). Several previous studies have consistently shown that childhood adversities are associated with asthma (Exley et al 2015), bronchitis (Springer et al 2007), hypothyroid (Post et al 2013), migraine (Post et al 2013), and psychiatric disorders (Sheikh et al 2014;Sheikh et al 2016a;Sheikh et al 2016b) in later life.…”