This research used descriptive qualitative approach. Research is conducted to show effectiveness of learning activities based on learning cycle 7E model by chemistry teachers' perspective. Data collected through an openended questionnaire which consist of 8 item that is 7 phases learning cycle 7E model and 1 effectiveness of learning cycle 7E model activities on acid-base concept. Purposive sampling was used in this research and there were 12 chemistry teachers that teach class XI in Yogyakarta city. Activities of learning cycle 7E model consists of 7 phases, namely elicitation, engagement, exploration, explanation, elaboration, evaluation, and extension. The result of research showed that the prospective chemistry teachers' that learning activities based on learning cycle 7E model is effective to be applied which each phase attention to careful time management on the acid-base concept. However, this research did not explore implementation effect size this model in the learning process of acid-base concept.