Contextual fear conditioning is associated with an increase of acetylcholine release in the hippocampus of rat

Nail-Boucherie, Karine; Dourmap, Nathalie; Jaffard, Robert; Costentin, Jean

doi:10.1016/s0926-6410(99)00058-0

Cited by 64 publications

(35 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When the tone CS predicts the occurrence of the US in a precise (explicit) time-dependent manner (CS-US pairing; context in the background), the increment in ACh release is less than in a situation in which contextual stimuli are the primary stimuli to enter into association with the US (CS-US unpairing; context in the foreground). Hence, in agreement with the well documented role of the hippocampus in contextual conditioning (Selden et al, 1991;Holland and Bouton, 1999;LeDoux, 2000;Nail-Boucherie et al, 2000;Anagnostaras et al, 2001;Maren, 2001;Desmedt et al, 2003;Rudy et al, 2004), the magnitude of ACh release would reflect the degree to which the static contextual stimuli are processed by the hippocampus for their subsequent association with the US.…”

Section: Hippocampal Ach Contributes To the Selection Of Relevant Cssupporting

confidence: 73%

Extracellular Hippocampal Acetylcholine Level Controls Amygdala Function and Promotes Adaptive Conditioned Emotional Response

Calandreau¹,

Trifilieff²,

Mons³

et al. 2006

J. Neurosci.

View full text Add to dashboard Cite

Ample data indicate that tone and contextual fear conditioning differentially require the amygdala and the hippocampus. However, mechanisms subserving the adaptive selection among environmental stimuli (discrete tone vs context) of those that best predict an aversive event are still elusive. Because the hippocampal cholinergic neurotransmission is thought to play a critical role in the coordination between different memory systems leading to the selection of appropriate behavioral strategies, we hypothesized that this cholinergic signal may control the competing acquisition of amygdala-mediated tone and contextual conditioning. Using pavlovian fear conditioning in mice, we first show a higher level of hippocampal acetylcholine release and a specific pattern of extracellular signalregulated kinase 1/2 (ERK1/2) activation within the lateral (LA) and basolateral (BLA) amygdala under conditions in which the context is a better predictor than a discrete tone stimulus. Second, we demonstrate that levels of hippocampal cholinergic neurotransmission are causally related to the patterns of ERK1/2 activation in amygdala nuclei and actually determine the selection among the context or the simple tone the stimulus that best predicts the aversive event. Specifically, decreasing the hippocampal cholinergic signal not only impaired contextual conditioning but also mimicked conditioning to the discrete tone, both in terms of the behavioral outcome and the LA/BLA ERK1/2 activation pattern. Conversely, increasing this cholinergic signal not only disrupted tone conditioning but also promoted contextual fear conditioning. Hence, these findings highlight that hippocampal cholinergic neurotransmission controls amygdala function, thereby leading to the selection of relevant emotional information.

show abstract

Section: Hippocampal Ach Contributes To the Selection Of Relevant Cssupporting

confidence: 73%

Extracellular Hippocampal Acetylcholine Level Controls Amygdala Function and Promotes Adaptive Conditioned Emotional Response

Calandreau¹,

Trifilieff²,

Mons³

et al. 2006

J. Neurosci.

View full text Add to dashboard Cite

show abstract

“…One possible explanation is the difference in the nature of the physical and psychological stresses. Recently, evidence has shown that the release of acetylcholine was increased in response to psychological stress, including sensory stress (46), auditory stimulation (12), and fearconditioned stress (47). Furthermore, local microinjection of baclofen into the PPT, where most cholinergic neurons are located in the brain, significantly reduced the total REM sleep through inhibition of cholinergic activity (37).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Baclofen on Alterations in the Sleep Patterns Induced by Different Stressors in Rats

Cui

Suemaru

et al. 2009

J Pharmacol Sci

View full text Add to dashboard Cite

Abstract. We have previously reported that sleep patterns are significantly affected by both physical and psychological stress induced by a communication box ; however, the mechanism by which stress alters sleep patterns was not established. In the present study, we investigated the role of γ-aminobutyric acid (GABA), acting through the GABA B receptor, on stress-induced changes in sleep patterns. Our results show that physical stress increased the total wakefulness time by increasing sleep latency and inhibiting both rapid eye movement (REM) and non rapid eye movement (NREM) sleep during a 6 h sleep-recording period. The GABA B agonist baclofen (20 pmol /2 μl) attenuated the effects of physical stress on sleep latency, total wakefulness, and NREM sleep, but not total REM sleep. In contrast, psychological stress enhanced total REM sleep and shortened REM sleep latency without altering other sleep patterns. The effect of psychological stress on total REM sleep was also reversed by baclofen. These results suggest that GABA via GABA B receptors may play a role in the regulation of specific sleep patterns by both physical and psychological stress.

show abstract

“…Hall et al (2001) found that the plasticity-associated immediate early gene zif268 was selectively activated in hippocampal CA 1 neurons during the recall of contextual fear memories. A neurochemical study has also demonstrated that the release of acetylcholine, a major neurotransmitter in the hippocampus, increases during the retrieval of contextual fear memories in rats (Nail-Boucherie et al, 2000), indicating that hippocampal processing is enhanced during this period. We therefore investigated the activity of hippocampal CA 1 pyramidal neurons during freezing behavior induced by contextual stimuli.…”

Section: Introductionmentioning

confidence: 99%

Endogenous 5‐HT inhibits firing activity of hippocampal CA₁ pyramidal neurons during conditioned fear stress‐induced freezing behavior through stimulating 5‐HT_1A receptors

et al. 2004

View full text Add to dashboard Cite

This study examines the activity of hippocampal CA, pyramidal neurons during conditioned fear stress (CFS)-induced freezing behavior in unanesthetized, unrestrained rats. The firing frequency of hippocampal CA1 pyramidal neurons was significantly decreased when conditioned rats exhibited freezing behavior. Firing frequency returned to the baseline after freezing behavior disappeared. The selective 5-hydroxytryptamine (5-HT)1A antagonists, N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide (WAY-100635), and N-tert-butyl-3-[4-(2-methoxyphenyl)piperazine-1-yl]-2-phenylpropamide (WAY-100135) and 5-HT depletion with parachlorophenylalanine (PCPA) completely abolished the decrease in firing frequency during CFS-induced freezing behavior. These results suggested that endogenous 5-HT inhibited the firing activity of hippocampal CA1 pyramidal neurons during CFS-induced freezing behavior mainly through stimulating 5-HT1A receptors.

show abstract

Contextual fear conditioning is associated with an increase of acetylcholine release in the hippocampus of rat

Cited by 64 publications

References 22 publications

Extracellular Hippocampal Acetylcholine Level Controls Amygdala Function and Promotes Adaptive Conditioned Emotional Response

Extracellular Hippocampal Acetylcholine Level Controls Amygdala Function and Promotes Adaptive Conditioned Emotional Response

The Effect of Baclofen on Alterations in the Sleep Patterns Induced by Different Stressors in Rats

Endogenous 5‐HT inhibits firing activity of hippocampal CA₁ pyramidal neurons during conditioned fear stress‐induced freezing behavior through stimulating 5‐HT_1A receptors

Contact Info

Product

Resources

About

Contextual fear conditioning is associated with an increase of acetylcholine release in the hippocampus of rat

Cited by 64 publications

References 22 publications

Extracellular Hippocampal Acetylcholine Level Controls Amygdala Function and Promotes Adaptive Conditioned Emotional Response

Extracellular Hippocampal Acetylcholine Level Controls Amygdala Function and Promotes Adaptive Conditioned Emotional Response

The Effect of Baclofen on Alterations in the Sleep Patterns Induced by Different Stressors in Rats

Endogenous 5‐HT inhibits firing activity of hippocampal CA1 pyramidal neurons during conditioned fear stress‐induced freezing behavior through stimulating 5‐HT1A receptors

Contact Info

Product

Resources

About

Endogenous 5‐HT inhibits firing activity of hippocampal CA₁ pyramidal neurons during conditioned fear stress‐induced freezing behavior through stimulating 5‐HT_1A receptors