Context-Specific Tolerance and Pharmacological Changes in the Infralimbic Cortex-Nucleus Accumbens Shell Pathway Evoked by Ketamine

Silva-Cardoso, Gleice Kelli; Nobre, Manoel Jorge

doi:10.1007/s11064-021-03300-6

Cited by 5 publications

(3 citation statements)

References 77 publications

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“…This context-specific tolerance has been observed for a wide range of drugs including alcohol, ketamine, and morphine [59][60][61]. The mechanism behind context-specific behavioral tolerance in ketamine use has been explained neurochemically by changes in dopamine release in different parts of the brain, specifically an increase in the infralimbic cortex and a decrease in the nucleus accumbens shell [59]. Thus, in some cases, the surrounding context is a key input to the control circuit and must be taken into account in approaches to design interventions.…”

Section: Tolerance and Sensitization: The Ubiquitous Atoms Of Complex...mentioning

confidence: 80%

“…For this tolerance to develop, the environmental cues presented at the time of drug administration trigger the behavioral tolerance to the effect of the drug. This context-specific tolerance has been observed for a wide range of drugs including alcohol, ketamine, and morphine [59][60][61]. The mechanism behind context-specific behavioral tolerance in ketamine use has been explained neurochemically by changes in dopamine release in different parts of the brain, specifically an increase in the infralimbic cortex and a decrease in the nucleus accumbens shell [59].…”

Section: Tolerance and Sensitization: The Ubiquitous Atoms Of Complex...mentioning

confidence: 96%

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Cellular Signaling Pathways as Plastic, Proto-cognitive Systems: Implications for Biomedicine

Mathews¹,

Chang²,

Devlin³

et al. 2022

Preprint

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Many aspects of health and disease are modeled using the abstraction of a “pathway” – a set of protein or other subcellular activities with specified functional linkages between them. This metaphor is a paradigmatic case of a deterministic, mechanistic framework that focuses biomedical intervention strategies on altering the members of this network or the up/down-regulation links between them – rewiring the molecular hardware. However, protein pathways and transcriptional networks share important properties with neural networks and related dynamical systems, which implies that they can exhibit interesting and unexpected capabilities such as trainability (memory) and information processing in a context-sensitive manner. Specifically, they may be amenable to manipulation via their history of stimuli (equivalent to experiences, in behavioral science). If true, this would enable a new class of biomedical interventions that targets aspects of the dynamic physiological “software” implemented by pathways and gene-regulatory networks. Here, we propose an expanded view of pathways from the perspective of basal cognition. We review clinical and laboratory data supporting the idea that a broader understanding of pathways (and how they process contextual information across scales) is a limiting factor for progress in many areas of physiology and neurobiology. We argue that a fuller understanding of the functionality and tractability of pathways must go beyond a focus on the mechanistic details of their structure, to encompass their physiological history and embedding within higher levels of organization in the organism, with numerous implications for data science addressing health and disease. Exploiting tools and concepts from behavioral and cognitive sciences is not just a philosophical stance on biochemical processes; at stake is a new roadmap for overcoming the limitations of today’s pharmacological strategies and for the inference of future therapeutic interventions impacting a wide range of disease states.

show abstract

Section: Tolerance and Sensitization: The Ubiquitous Atoms Of Complex...mentioning

confidence: 80%

Section: Tolerance and Sensitization: The Ubiquitous Atoms Of Complex...mentioning

confidence: 96%

Cellular Signaling Pathways as Plastic, Proto-cognitive Systems: Implications for Biomedicine

Mathews¹,

Chang²,

Devlin³

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Context-specific tolerance has been observed for a wide range of drugs including alcohol, ketamine, and morphine. 56 , 57 , 58 The mechanism behind context-specific behavioral tolerance in ketamine use has been explained neurochemically by changes in dopamine release in different parts of the brain, specifically an increase in the infralimbic cortex and a decrease in the nucleus accumbens shell. 56 Thus, in some cases, the surrounding context is a key input to the control circuit and must be taken into account in designing interventions.…”

Section: Tolerance and Sensitization: The Ubiquitous Atoms Of Complex...mentioning

confidence: 99%

Cellular signaling pathways as plastic, proto-cognitive systems: Implications for biomedicine

Mathews¹,

Chang²,

Devlin³

et al. 2023

Patterns

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Cannabidiol and pain

Nascimento,

Escobar-Espinal,

Bálico

et al. 2024

International Review of Neurobiology

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Context-Specific Tolerance and Pharmacological Changes in the Infralimbic Cortex-Nucleus Accumbens Shell Pathway Evoked by Ketamine

Cited by 5 publications

References 77 publications

Cellular Signaling Pathways as Plastic, Proto-cognitive Systems: Implications for Biomedicine

Cellular Signaling Pathways as Plastic, Proto-cognitive Systems: Implications for Biomedicine

Cellular signaling pathways as plastic, proto-cognitive systems: Implications for biomedicine

Cannabidiol and pain

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