Cellular signaling pathways as plastic, proto-cognitive systems: Implications for biomedicine

Mathews, Juanita; Chang, Alan L.; Devlin, L.M.; Levin, Michael

doi:10.1016/j.patter.2023.100737

Cited by 18 publications

(9 citation statements)

References 256 publications

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“…More broadly, our approach has identied a method for generating testable hypotheses in the space of developmental bioelectricity, which has implications for birth defects, traumatic injury, and cancer. 57,[105][106][107] Future work will incorporate this kind of workow into machine science pipelines, and empirically test the creative products of exploring the structures of concepts among diverse elds of inquiry. It is clear however that this approach in exploring the latent space around existing scientic literature extends far beyond bioelectricity and can be applied to numerous domains.…”

Section: Discussionmentioning

confidence: 99%

Machine learning for hypothesis generation in biology and medicine: exploring the latent space of neuroscience and developmental bioelectricity

O'Brien,

Stremmel,

Pio-Lopez

et al. 2024

Digital Discovery

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Section: Discussionmentioning

confidence: 99%

Machine learning for hypothesis generation in biology and medicine: exploring the latent space of neuroscience and developmental bioelectricity

O'Brien,

Stremmel,

Pio-Lopez

et al. 2024

Digital Discovery

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“…to the rat hosts in which we can implant them. The lessons we learn will likely be actionable for making new kinds of truly bio-inspired AI architectures [178], and also help design strategies for regenerative biomedicine that target how cells and tissues interpret the interventions we provide in the form of biochemical and bioelectrical stimuli [101,179,180].…”

Section: What It Means and What Nextmentioning

confidence: 99%

Self-improvising Memory: a perspective on memories as agential, dynamically-reinterpreting cognitive glue

Levin

2024

Preprint

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Many studies of memory focus on the material substrate in which data can be stored and reliably read out. Here, I focus on the complementary aspects: the need for agents to dynamically re-interpret and modify memories to suit their ever-changing selves and environment. Using examples from developmental biology, evolution, and synthetic bioengineering, in addition to neuroscience, I propose that a perspective on memory as preserving salience, not fidelity, is applicable to many phenomena on scales from cells to societies. I focus on continuous commitment to confabulation, from the molecular to the behavioral levels, as the answer to the persistence paradox as it applies to individuals and whole lineages. I also speculate that a substrate-independent, processual view of life and mind suggests that memories, as patterns in the excitable medium of cognitive systems, could be seen as active agents in the sense-making process. I explore a view of life and agency as a diverse set of embodied Perspectives – nested agents who interpret each other’s and their own past messages and actions as best as they can (polycomputation). This synthesis suggests unifying symmetries across scales and disciplines, of relevance to research programs in diverse intelligence and the engineering of novel embodied minds.

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“…This process requires multiple synapses and neurotransmitters for learning and plasticity to occur. These neurotransmitters and synapses essential for plasticity include gamma-aminobutyric acid (GABA), glutamate, acetylcholine, and dopamine [ 8 , 9 ]. Glutamine (excitatory) and GABA (inhibitory) ratios are balanced in normal individuals.…”

Section: Reviewmentioning

confidence: 99%

The Physiology of Cognition in Autism Spectrum Disorder: Current and Future Challenges

Al-Mazidi

2023

Cureus

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Cognitive impairment is among the most challenging characteristics of autism spectrum disorder (ASD). Although ASD is one of the common neurodevelopmental disorders, we are still behind in diagnosing and treating cognitive impairment in ASD. Cognitive impairment in ASD varies, meaning it could be at the sensory perception level to cognitive processing, learning, and memory. There are no diagnostic criteria for cognitive impairment that are specific to ASD. The leading causes of cognitive impairment in ASD could be neurological, immune, and gastrointestinal dysfunction. Immune dysfunction might lead to neuroinflammation, affecting neural connectivity, glutamate/gamma-aminobutyric acid (GABA) balance, and plasticity. The gut-brain axes are essential in the developing brain. Special retinal changes have recently been detected in ASD, which need clinical investigation to find their possible role in early diagnosis. Early intervention is crucial for ASD cognitive dysfunction. Due to the heterogeneity of the disease, the clinical manifestation of ASD makes it difficult for clinicians to develop gold-standard diagnostic and therapeutic criteria. We suggest a triad for diagnosis, which includes clinical tests for immune and gastrointestinal dysfunction biomarkers, clinical examination for the retina, and an objective neurocognitive evaluation for ASD, and to develop a treatment strategy involving these three aspects. Developing clear treatment criteria for cognitive impairment for ASD would improve the quality of life of ASD people and their caregivers and would delay or prevent dementia-related disorders in ASD people.

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Cellular signaling pathways as plastic, proto-cognitive systems: Implications for biomedicine

Cited by 18 publications

References 256 publications

Machine learning for hypothesis generation in biology and medicine: exploring the latent space of neuroscience and developmental bioelectricity

Machine learning for hypothesis generation in biology and medicine: exploring the latent space of neuroscience and developmental bioelectricity

Self-improvising Memory: a perspective on memories as agential, dynamically-reinterpreting cognitive glue

The Physiology of Cognition in Autism Spectrum Disorder: Current and Future Challenges

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