Contents of tissue CEA and CA19-9 in colonic polyp and colorectal cancer, and their clinical significance

Elevated Carbohydrate Antigen 19-9 Caused by Early Colon Cancer Treated with Endoscopic Mucosal Resection

“…Unlike serum CA 19-9 levels, cytosol CA 19-9 contents in adenomatous polyps and adenocarcinoma are significantly higher than those in normal mucosa [3,4]. Imamura et al [4] reported that these levels vary significantly according to polyp size, histological type, and grade of dysplasia.…”

“…Imamura et al [4] reported that these levels vary significantly according to polyp size, histological type, and grade of dysplasia. Interestingly, there was no correlation between serum levels and tissue contents of CA 19-9 in colonic adenomas and CRCs.…”

Survival of patients with colorectal carcinoma

“…Different studies with immunohistochemical techniques have been conducted to achieve this objective. 14,[21][22][23] Nevertheless, only a few studies have focused on CA 19.9 contents in CRC. Okuda et al 24 attempted to stain tissue with CA 19.9 from specimens of resected CRC and observed a lack of correlation between this tumor marker and CEA contents.…”

“…This may be due to a morphologic heterogeneity characterized by a nearly normal differentiation or to a marked anaplasia or aneuploidy often observed in a single neoplasm. 26 -30 According to Imamura et al, 23 in relation to tissue content of CEA in CRC, CEA contents in pericancerous tissues can be attributed to the "diffusion" of CEA from cancerous regions to noncancerous regions. It is more likely that tissues surrounding the tumor have a higher potential to become malignant.…”

“…Other researchers have observed levels similar to ours. 23,26 However, the cut-off point may require optimization with a higher number of determinations by different laboratories with a double-blind quality control.…”