Role of serum carbohydrate antigen 19-9 and carcinoembryonic antigen in distinguishing between benign and invasive intraductal papillary mucinous neoplasm of the pancreas (Br J Surg 2011; 98: 104–110)

Abstract

Das 3,3′‐Pyrrolidinylspirooxindol‐System ist ein privilegiertes heterocyclisches Strukturmotiv, das die zentrale Einheit bei einer großen Familie von natürlichen Alkaloiden mit starken Bioaktivitätsprofilen und interessanten Struktureigenschaften bildet. Neue bedeutende Fortschritte bei der Synthese dieses kondensierten heterocyclischen Systems haben ein starkes Interesse an der Entwicklung verwandter Verbindungen als mögliche Wirkstoffe oder biologische Sonden hervorgerufen.

The Value of Serum Tumor Markers and Blood Inflammation Markers in Differentiating Pancreatic Serous Cystic Neoplasms and Pancreatic Mucinous Cystic Neoplasms

“…The serum tumor marker, CA199 (a tumorrelated carbohydrate protein), plays an important role in the diagnosis, treatment, and postoperative follow-up of pancreatic cancer. Increasing evidence indicates that serum CA199 levels play an important role in differentiating the benign and malignant properties of PCNs (25)(26)(27). Postlewait et al (28) analyzed the preoperative blood CA199 level of 349 cases of MCNs and found that the median CA199 level in the malignant group was 210 U/ml; in the nonmalignant group, the median CA199 level was only 15 U/ml (p = 0.001), suggesting that the elevated level of serum CA199 indicated malignant MCNs, which was consistent with the results of the present study.…”