Content and Release of Bisphenol A from Polycarbonate Dental Products.

Suzuki, Kazuomi; Ishikawa, Kunio; Sugiyama, Katsumi; Furuta, Hiroaki; Nishimura, Fumio

doi:10.4012/dmj.19.389

Cited by 71 publications

(55 citation statements)

References 9 publications

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“…In vitro studies have documented the release of BPA from polycarbonate brackets [30], orthodontic adhesives [31,32] and resin composites that are frequently used for bonding lingual retainers [30]. For traditional and flowable resin composites used as lingual retainers, BPA release was confirmed in vivo as well [33], with the highest values in saliva measured immediately after polymerization.…”

Section: Introductionmentioning

confidence: 94%

BPA qualtitative and quantitative assessment associated with orthodontic bonding in vivo

et al. 2015

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OBJECTIVE: To assess the in vivo amount of BPA released from a visible light-cured orthodontic adhesive, immediately after bracket bonding. METHODS: 20 orthodontic patients were recruited after obtaining informed consent. All patients received 24 orthodontic brackets in both dental arches. In Group A (11 patients), 25 ml of tap water were used for mouth rinsing, whereas in Group B (9 patients) a simulated mouth rinse formulation was used: a mixture of 20 ml de-ionized water plus 5 ml absolute ethanol. Rinsing solutions were collected before, immediately after placing the orthodontic appliances and after washing out the oral cavity and were then stored in glass tubes. Rinsing was performed in a single phase for 60s with the entire volume of each liquid. The BPA analysis was performed by gas chromatography-mass spectrometry. RESULTS: An increase in BPA concentration immediately after the 1st post-bonding rinse was observed, for both rinsing media, which was reduced after the 2nd postbonding rinse. Water exhibited higher levels of BPA concentration than water/ethanol after 1st and 2nd post-bonding rinses. Two-way mixed Repeated Measures ANOVA showed that the primary null hypothesis declaring mean BPA concentration to be equal across rinsing medium and rinsing status was rejected (p-value <0.001). The main effects of the rinsing medium and status, as well as their interaction were found to be statistically significant (p-values 0.048, <0.001 and 0.011 respectively). SIGNIFICANCE: A significant pattern of increase of BPA concentration, followed by a decrease that reached the initial values was observed. The amount of BPA was relatively low and far below the reference limits of tolerable daily intake. Methods: 20 volunteers were recruited after obtaining informed consent. All patients received 24 orthodontic brackets in both dental arches. In Group A (11 patients), 25 ml of tap water were used for mouth rinsing, whereas in Group B (9 patients) a simulated mouth rinse formulation was used: a mixture of 20 ml de--ionized water plus 5 ml absolute ethanol. Rinsing solutions were collected before, immediately after placing the orthodontic appliances and after washing out the oral cavity and were then stored in glass tubes. Rinsing was performed in a single phase for 60 seconds with the entire volume of each liquid. The BPA analysis was performed by gas chromatography--mass spectrometry.Results: An increase in BPA concentration immediately after the 1 st post--bonding rinse was observed, for both rinsing media, which was reduced after the 2 nd post--bonding rinse. Water exhibited higher levels of BPA concentration than water/ethanol after 1st and 2nd post--bonding rinses. Two--way mixed Repeated Measures ANOVA showed that the primary null hypothesis declaring mean BPA concentration to be equal across rinsing medium and rinsing status was rejected (p--value < 0.001). The main effects of the rinsing medium and status, as well as their interaction were found to be statistically significant (p--values 0.048, <0.001 an...

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Section: Introductionmentioning

confidence: 94%

BPA qualtitative and quantitative assessment associated with orthodontic bonding in vivo

et al. 2015

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“…It is the highest volume chemical produced worldwide and mimics the naturally occurring estrogen, estradiol 17β. BPA is used in the production of epoxy resin lining of food and beverage containers, polycarbonate plastic (Vom Saal, Hughes, 2005), as a constituent of dental sealant (Olea et al, 1996;Vandenberg et al, 2007), as a flame retardant precursor and also used in the production of thermal papers and carbonless copy (Suzuki et al, 2000;Debenest et al, 2010;Liao, Kannan, 2011). Several studies suggest that BPA cause acute, short-term and sub-chronic toxicity (Tyl et al, 2002;Tyl, 2008).…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress and histopathologic biomarkers of exposure to bisphenol-A in the freshwater fish, Ctenopharyngodon idella

Faheem

Lone

2018

Braz. J. Pharm. Sci.

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Bisphenol-A (BPA) belongs to the family of endocrine disrupting chemicals (EDCs) and it is used in the production of polycarbonate plastic and epoxy resins. The reproductive toxicity of BPA is well documented but it also exerts its toxic effects through multiple pathways especially by inducing a state of oxidative stress and causing damage to the vital organs. In the present study, histopathologic and oxidative damage caused by BPA in liver and kidneys of fresh water cyprinid, Ctenopharyngodon idella was evaluated. LC 50 of BPA for Ctenopharyngodon idella was determined by probit regression analysis. Fish were exposed to a sublethal concentration of BPA i.e. 3.2 ppm (1/2 LC 50 ) for 14 days. Histologic studies revealed that BPA caused degenerative changes in liver and kidneys and exposure of sublethal concentration of BPA caused oxidative damage in both organs. Lipid peroxidation significantly increased in liver and kidneys of treated group. Catalase activity and reduced glutathione content significantly decreased in the group exposed to BPA compared to control and glutathione-S-transferase activity increased significantly in both organs exposed to the sublethal concentration of BPA. From this study it is concluded that BPA caused toxic effects in fish species by changing oxidative balance and damaging the vital organs.

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“…Another study found plastic orthodontic brackets in water to release bisphenol A at 0.01-0.40 mg/kg material and denture base resin in water to release bisphenol A at 0.01-0.09 mg/kg material (Suzuki et al, 2000).…”

Section: Fcpsa (2005)mentioning

confidence: 99%

NTP‐CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A

Chapin

Adams

Boekelheide

et al. 2008

Birth Defects Research Pt B

401

304

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Content and Release of Bisphenol A from Polycarbonate Dental Products.

Cited by 71 publications

References 9 publications

BPA qualtitative and quantitative assessment associated with orthodontic bonding in vivo

BPA qualtitative and quantitative assessment associated with orthodontic bonding in vivo

Oxidative stress and histopathologic biomarkers of exposure to bisphenol-A in the freshwater fish, Ctenopharyngodon idella

NTP‐CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A

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