Content and composition of essential oil and content of rosmarinic acid in lemon balm and balm genotypes (Melissa officinalis)

Kittler, Johannes; Krüger, Hans; Ulrich, Detlef; Zeiger, Bärbel; Schütze, Wolfgang; Böttcher, Christoph; Krähmer, Andrea; Gudi, Gennadi; Kästner, Ute; Heuberger, Heidi; Marthe, Frank

doi:10.1007/s10722-018-0635-4

Cited by 16 publications

(12 citation statements)

References 16 publications

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“…The principal constituents detected in the essential oil from M. officinalis by GC-MS were monoterpenes and sesquiterpenes (Table 1; GC-MS total ion chromatogram is shown in the Supplementary Figure S1), with composition data consistent with that previously reported for M. officinalis oil (Elliott et al, 2007), and with the citral chemotype reported for this species (Kittler et al, 2018a;2018b).…”

Section: Chemical Composition Of M Officinalis Oilsupporting

confidence: 87%

New Insights Into the Anticonvulsant Effects of Essential Oil From Melissa officinalis L. (Lemon Balm)

et al. 2021

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Melissa officinalis L. is used in traditional European and Iranian folk medicines to treat a plethora of neurological diseases including epilepsy. We utilized the in vitro and in vivo models of epilepsy to probe the anticonvulsant potentials of essential oil from M. officinalis (MO) to gain insight into the scientific basis for its applications in traditional medicine for the management of convulsive disorders. MO was evaluated for effects on maximal electroshock (MES) and pentylenetetrazole (PTZ) -induced seizures in mice, on 4–aminopyridine (4-AP)-brain slice model of epilepsy and sustained repetitive firing of current clamped neurons; and its ameliorative effects were examined on seizure severity, anxiety, depression, cognitive dysfunction, oxidative stress and neuronal cell loss in PTZ-kindled rats. MO reversibly blocked spontaneous ictal-like discharges in the 4-AP-brain slice model of epilepsy and secondary spikes from sustained repetitive firing, suggesting anticonvulsant effects and voltage-gated sodium channel blockade. MO protected mice from PTZ– and MES–induced seizures and mortality, and ameliorated seizure severity, fear-avoidance, depressive-like behavior, cognitive deficits, oxidative stress and neuronal cell loss in PTZ–kindled rats. The findings warrant further study for the potential use of MO and/or its constituent(s) as adjunctive therapy for epileptic patients.

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Section: Chemical Composition Of M Officinalis Oilsupporting

confidence: 87%

New Insights Into the Anticonvulsant Effects of Essential Oil From Melissa officinalis L. (Lemon Balm)

et al. 2021

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“…In plants of two genotypes, caryophyllene epoxide, germacrene-D and ß-caryophyllene had the highest sesquiterpene compounds, respectively, regardless of light treatments. As in the present study, in Jalal et al's study (2015), the main sesquiterpene of lemon balm was ß-caryophyllene epoxide (11%) and in the study of Kittler et al (2018) ß-caryophyllene, germacrene-D and ß-caryophyllene epoxide constituted the main sesquiterpene compounds of lemon balm genotypes. However, in the study conducted by Chung et al (2010), caryophyllene (0.8%) and farnesene (0.1%) were the most common sesquiterpene.…”

Section: Sesquiterpenes Content Under Various Light Treatments In Twosupporting

confidence: 74%

“…Kittler et al (2018) ß-caryophyllene, germacrene-D and ß-caryophyllene epoxide constituted the main sesquiterpene compounds of lemon balm genotypes. However, in the study conducted byChung et al (2010), caryophyllene (0.8%) and farnesene (0.1%) were the most common sesquiterpene.…”

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confidence: 98%

LED Light Sources Improved the Essential Oil Components and Antioxidant Activity of Two Genotypes of Lemon Balm (Melissa Officinalis L.)

Ahmadi

Shabani

Sabzalian

2021

Preprint

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Here we investigated the effect of different LED light sources on the essential oil components and antioxidant activity of Melissa officinalis. Two genotypes of lemon balm (Ilam and Isfahan) were subjected to four artificial light treatments including white, red, blue, red + blue LEDs and greenhouse light as natural lighting. The LED lights significantly increased shoot fresh and dry weights and Leaf number in the two genotypes as compared to greenhouse condition. The results showed that the content and composition of essential oil in two genotypes was variable under different light treatments and the total amount of compounds in Ilam genotype was higher than the other genotype. The results of analysis of the essential oil by GC/MS indicated that the highest amount of monoterpenes in the genotypes was related to citronellal under red + blue LED lamps (15.3 and 17.2% in Ilam and Isfahan genotypes, respectively) but blue, white, and greenhouse condition had the most effect on sesquiterpenes content in both genotypes. Furthermore, the observed variation between the two genotypes in the essentials oil composition was related to the relative percentage of the constituents and not to the appearance or lack of a specific component. Red + blue lighting also caused the highest radical scavenging activity % in both genotypes (80.77 and 82.09% for Ilam and Isfahan genotypes, respectively). Based on principal component analyses (PCA), three main groups were identified regarding genotypes and all light treatments. Overall, results indicated that the essentials oil composition of two genotypes of lemon balm was affected both qualitatively and quantitatively by different LED light sources; hence, LED lights might be used to improve monoterpenes, sesquiterpenes and antioxidant activity in the selected genotypes.

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“…Different organic compounds present in lemon balm extract including protein, essential oils, avonoids, rosmarinic, caffeic and gallic acids and phenolic contents are responsible for bio-reduction of Ag + ions [19,21]. M. o cinalis as a valuable source of natural antioxidants has strong antimicrobial activity [22,23]. In the present study, silver nanoparticles (AgNPs) were synthesized using aqueous and methanolic extracts of Melissa o cinalis.…”

Section: Introductionmentioning

confidence: 99%

Phyto-mediated silver nanoparticles via Mellisa officinalis aqueous and methanolic extracts: synthesis, characterization and biological properties

Nayeri

Mafakheri

Mirhosseini

2020

Preprint

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The aim of the study was to examine the influence of extraction method on the size, shape and morphology of synthesized silver nanoparticles (AgNPs). Silver nanoparticles were prepared by the aqueous and methanolic extracts of lemon balm. The properties of obtained nanoparticles were characterized by UV-Vis, SEM, XRD and FTIR techniques. The UV-Vis spectroscopy confirmed the formation of AgNPs by observing a distinct surface Plasmon resonance band around 450 nm. SEM images showed different shape, size and morphology of AgNPs using two different extracts types. AgNPs derived from the aqueous extract were rod-shaped with a diameter of 19 to 40 nm whereas spherical particles were synthesized by the methanolic extract found smaller with size distribution ranging from 13 to 35 nm. The XRD pattern indicated that AgNPs formed by the reduction of Ag + ions using methanolic extract of M. officinalis were crystal-like in nature. The functional groups of M. officinalis methanolic extract involved in synthesis and stabilization of AgNPs were investigated by FTIR. In addition, AgNPs-containing methanolic extract showed higher antioxidant activity. These particles exhibited remarkable antimicrobial activity against gram positive and negative bacteria and a fungus. The nanoparticles produced by the methanolic extract of the lemon balm showed antioxidant and antimicrobial activity. The production of silver nanoparticles using plant extract is rapid, low cost and eco-friendly. Therefore, green chemistry is a good alternative to industrial production of nanoparticles. Silver nanoparticles can be used as an antiseptic to sterilize the surrounding area and the hospital wastes.

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Content and composition of essential oil and content of rosmarinic acid in lemon balm and balm genotypes (Melissa officinalis)

Cited by 16 publications

References 16 publications

New Insights Into the Anticonvulsant Effects of Essential Oil From Melissa officinalis L. (Lemon Balm)

New Insights Into the Anticonvulsant Effects of Essential Oil From Melissa officinalis L. (Lemon Balm)

LED Light Sources Improved the Essential Oil Components and Antioxidant Activity of Two Genotypes of Lemon Balm (Melissa Officinalis L.)

Phyto-mediated silver nanoparticles via Mellisa officinalis aqueous and methanolic extracts: synthesis, characterization and biological properties

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