Contemporary trends in toxicological research on arsenic

Abstract

There is a plethora of recent publications on all aspects relevant to the toxicology of arsenic (As). Over centuries exposures to arsenic continue to be a major public health problem in many countries. In particular, the occurrence of high As concentrations in groundwater of Southeast Asia receives now much attention. Therefore, arsenic is a high-priority matter for toxicological research. Key exposure to As are (traditional) medicines, combustion of As-rich coal, presence of As in groundwater, and pollution due to mining activities. As-induced cardiovascular disorders and carcinogenesis present themselves as a major research focus. The high priority of this issue is now recognized politically in a number of countries, research funds have been made available. Also experimental research on toxicokinetics and toxicodynamics and on modes of toxic action is moving very rapidly. The matter is of high regulatory concern, and effective preventive measures are required in a number of countries.

Arsenic: A Harmful and Desecrate Compound for the Humans

“…In a study by Pereira et al, Swiss albino mice were exposed to 10 µg arsenic trioxide/g body weight through oral route and 5 µg arsenic trioxide/g body weight through intraperitoneally for a duration of 30 days, it was found that there was altered hemogram values in the peripheral blood that reflected the altered hematopoiesis that was next evident by reduced bone marrow cellularity and deviated bone marrow cell morphology that was observed by scanning electron microscopy. The stromal cells were not able to maintain a healthy matrix [62].…”

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“…Arsenic compounds were among the first substances used to control agricultural pests (Bolt 2013). Significant concentrations of arsenic occur naturally in the environment, usually in conjunction with metals such as cobalt, nickel, iron, lead and copper (Chou and De Rosa 2003).…”