Deregulation of autophagy is involved in nephrotoxicity of arsenite and fluoride exposure during gestation to puberty in rat offspring

Tian, Xiaolin; Xie, Jiaxin; Chen, Xushen; Dong, Nisha; Feng, Jing; Gao, Yi; Tian, Fengjie; Zhang, Wenping; Qiu, Yulan; Niu, Ruiyan; Ren, Xuefeng; Yan, Xiaoyan

doi:10.1007/s00204-019-02651-y

Cited by 23 publications

(10 citation statements)

References 56 publications

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“…Some scholars have speculated that excessive fluoride may simultaneously cause ERS and autophagy in ameloblasts of developing teeth, thereby playing a role in the occurrence and development of dental fluorosis. However, the mechanism of mutual regulation between the two in the occurrence of dental fluorosis is yet to be fully explored (Tian et al, 2020).…”

Section: Autophagy and Oral Diseases Fluorine Spot Toothmentioning

confidence: 99%

Natural phytochemicals that affect autophagy in the treatment of oral diseases and infections: A review

2022

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Autophagy is a critical factor in eukaryotic evolution. Cells provide nutrition and energy during autophagy by destroying non-essential components, thereby allowing intracellular material conversion and managing temporary survival stress. Autophagy is linked to a variety of oral disorders, including the type and extent of oral malignancies. Furthermore, autophagy is important in lymphocyte formation, innate immunity, and the regulation of acquired immune responses. It is also required for immunological responses in the oral cavity. Knowledge of autophagy has aided in the identification and treatment of common oral disorders, most notably cancers. The involvement of autophagy in the oral immune system may offer a new understanding of the immune mechanism and provide a novel approach to eliminating harmful bacteria in the body. This review focuses on autophagy creation, innate and acquired immunological responses to autophagy, and the status of autophagy in microbial infection research. Recent developments in the regulatory mechanisms of autophagy and therapeutic applications in oral illnesses, particularly oral cancers, are also discussed. Finally, the relationship between various natural substances that may be used as medications and autophagy is investigated.

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Section: Autophagy and Oral Diseases Fluorine Spot Toothmentioning

confidence: 99%

Natural phytochemicals that affect autophagy in the treatment of oral diseases and infections: A review

2022

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“…Additionally, fluoride levels above the Mexican standard have been observed in Calvillo water [ 7 ]. Exposure to fluoride can cause kidney injury and FSGS [ 17 ] and maternal exposure may lead to kidney disease in offspring during puberty [ 18 ].…”

Section: An Agricultural Community and Fsgs As Guiding Clues For The ...mentioning

confidence: 99%

Solving the riddle of Aguascalientes nephropathy: nephron number, environmental toxins and family clustering

Villalvazo

Carriazo

Martín-Cleary

et al. 2022

Clinical Kidney Journal

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Aguascalientes, Mexico has a high incidence and prevalence of advanced chronic kidney disease (CKD). CKD is especially frequent in young people aged 20 to 40 years in whom the cause of CKD was unknown (CKDu), although kidney biopsies frequently showed focal segmental glomerulosclerosis (FSGS) and glomerulomegaly. Macias-Diaz et al have now pursued this lead by screening teenagers in Calvillo, one of the hardest hit municipalities. They uncovered clinical, laboratory, kidney biopsy and exposure findings that define a new entity, Aguascalientes nephropathy, and are consistent with familial exposure to common environmental toxins, potentially consisting of pesticides. They hypothesize that prenatal exposure to these toxins may decrease nephron number. The young age of persons with FSGS would be consistent with a novel environmental toxin introduced more than 50 years ago, but not present in the environment before. Key takeaways from this research are the need to screen teenagers for albuminuria, to provide kidney protective strategies to patients identified as having CKD and for the research community to support Aguascalientes nephrologists and health authorities to unravel the cause and potential solutions to this CKD hotspot. In this regard, the screening approach and the cohort generated by Macias-Diaz et al represent a giant step forward. The next steps should be to screen younger children for albuminuria and kidney size and to identify the putative toxins.

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“…In India, high serum and/or urine fluoride levels were found in 20% of children with nephrotic syndrome [ 63 ]. Indeed, foot process effacement, indicative of podocyte injury, was observed in mice exposed to fluoride [ 64 ]. Fluoride is the nephrotoxic component in methoxyflurane [ 65 ] and high bone fluoride (and lead) were found in Sri Lanka CKDu, although it was unclear to what extent they were caused or a consequence of CKD [ 66 ].…”

Section: What Might Cause Aguascalientes Nephropathy?mentioning

confidence: 99%

“…In this regard, exposure may have occurred years before and sources of exposure may already have been corrected. In pre-clinical studies, maternal exposure to excess fluoride may cause nephrotoxicity in offspring that becomes evident during puberty [ 64 ] and bone accumulation of lead and fluoride in persons may cause a slow release from endogenous sources and nephrotoxicity [ 66 ].…”

Section: What Might Cause Aguascalientes Nephropathy?mentioning

confidence: 99%

Aguascalientes: one of the hottest chronic kidney disease (CKD) hotspots in Mexico and a CKD of unknown aetiology mystery to be solved

Villalvazo

Carriazo

Martín-Cleary

et al. 2021

Clinical Kidney Journal

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In a recent issue of CKJ, Gutierrez-Peña et al reported a high incidence and prevalence of advanced chronic kidney disease (CKD) in Aguascalientes, Mexico. This contradicts Global Burden of Disease estimates that should be updated. A key component of this high burden of CKD relates to young people aged 20 to 40 years in whom the cause of CKD was unknown (CKDu). The incidence of kidney replacement therapy in this age group in Aguascalientes is among the highest in the world, second only to Taiwan. However, high altitude Aguascalientes with a year-round average temperature of 19 °C does not fit the geography of other CKDu hotspots. Furthermore, kidney biopsies in young people showed a high prevalence of focal segmental glomerulosclerosis. Potential causes of CKDu in Aguascalientes include the genetic background (no evidence, although podocytopathy genes should be explored) and environmental factors. The highest prevalence of CKD was found in Calvillo, known for guava farming. Thus, guava itself, known to contain bioactive, potentially nephrotoxic molecules, and pesticides should be explored. Additionally, there are reports of water sources in Aguascalientes contaminated with heavy metals and/or pesticides. These include fluoride (increased levels found in Calvillo drinking water) as well as naturally occurring arsenic, among others. Fluoride may accumulate in bone and cause kidney disease years later, and maternal exposure to excess fluoride may cause kidney disease in offspring. We propose a research agenda to clarify the cause of CKDu in Aguascalientes. that should involve international funders. The need for urgent action to identify and stem the cause of the high incidence of CKD extends to other CKD hotspots in Mexico, including Tierra Blanca in Veracruz and Poncitlan, Jalisco.

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Deregulation of autophagy is involved in nephrotoxicity of arsenite and fluoride exposure during gestation to puberty in rat offspring

Cited by 23 publications

References 56 publications

Natural phytochemicals that affect autophagy in the treatment of oral diseases and infections: A review

Natural phytochemicals that affect autophagy in the treatment of oral diseases and infections: A review

Solving the riddle of Aguascalientes nephropathy: nephron number, environmental toxins and family clustering

Aguascalientes: one of the hottest chronic kidney disease (CKD) hotspots in Mexico and a CKD of unknown aetiology mystery to be solved

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