Contemporary Concepts in Management of Acute Otitis Media in Children

Rettig, Eleni M.; Tunkel, David E.

doi:10.1016/j.otc.2014.06.006

Cited by 57 publications

(40 citation statements)

References 86 publications

(132 reference statements)

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“…AOM is the most common bacterial infection in children [39][40][41][42][43]. Consequently, AOM is the most common reason for antibiotic prescription in the pediatric age [44,45]. Almost all children experience at least one episode of AOM during childhood.…”

Section: Recurrent Acute Otitis Mediamentioning

confidence: 99%

Inflammation, infection, and allergy of upper airways: new insights from national and real-world studies

Varricchio¹,

Mantia

Brunese³

et al. 2020

Ital J Pediatr

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The upper airways (UA) should be considered as a functional unit. Current functional anatomy divides URT in three, mutually dependent, "junction boxes": i) the ostio-meatal complex (OMC), ii) the spheno-ethmoidal recess (SER), and iii) the rhinopharynx (RP). Correct ventilation and effective mucociliary clearance of these sites significantly affect the healthy physiology of the entire respiratory system. The OMC, SER, and RP obstruction is the first pathogenic step in the inflammatory/infectious cascade of UA disorders. The inflammation of the respiratory mucosa is the main pathogenic factor for airway obstruction. Moreover, bacterial biofilm (a strategy modality of bacterial survival) is an important local cause of systemic antibiotic ineffectiveness, recurrent infections, and antibiotic resistance. Health microbiota guarantees UA wellness; on the contrary, dysbiosis promotes and worsens UA infections. Allergy, namely type 2 inflammation, is a common cause of UA obstruction such as promoting in turn infections. Fiberoptic endoscopy is a mandatory diagnostic tool in clinical practice. Nasal cytology, mainly concerning flow cytometry, allows defining rhinitis phenotypes so allowing a precision medicine approach. Several conventional therapeutic approaches are available, but efficacy and safety should be ever properly considered before the prescription. Also, complementary medicine plays a fruitful role in the management of UA diseases. National and real-world studies are reported and discussed as they may be useful in daily clinical practice.

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Section: Recurrent Acute Otitis Mediamentioning

confidence: 99%

Inflammation, infection, and allergy of upper airways: new insights from national and real-world studies

Varricchio¹,

Mantia

Brunese³

et al. 2020

Ital J Pediatr

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“…TT are widely used in the human paediatric field (Rettig & Tunkel 2014, Wallace et al 2014) yet there remains limited evidence on the efficacy of their use in dogs in the veterinary literature (Cox & Slack 1989, Corfield et al 2008. Furthermore, in the largest study so far only three dogs were treated and TT were placed using an operating microscope which is not available in most veterinary practices.…”

Section: Introductionmentioning

confidence: 99%

Video‐otoscopy‐guided tympanostomy tube placement for treatment of middle ear effusion

Guérin

Hampel

Haar

2015

J of Small Animal Practice

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“…AOM is the most common bacterial infection in children 2–6. Consequently, AOM is the most common reason for antibiotic prescription in the pediatric age 7,8. Almost all children may experience at least one episode of AOM during the childhood.…”

Section: Introductionmentioning

confidence: 99%

Bacteriotherapy with <em>Streptococcus salivarius</em> 24SMB and <em>Streptococcus oralis</em> 89a nasal spray for preventing recurrent acute otitis media in children: a real-life clinical experience

Mantia¹,

Varricchio²,

Ciprandi³

2017

IJGM

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Recurrence of acute otitis media (RAOM) is a relevant issue in the clinical practice. “Bacteriotherapy” has been proposed as an option in children with RAOM. Streptococcus salivarius 24SMB nasal spray has been previously demonstrated to reduce the risk of acute otitis media (AOM) in otitis-prone children. The current retrospective and observational study aimed to confirm this outcome in a real-life setting, such as the common pediatric practice. Group A (108 children) served as control; group B (159 children) was treated with S. salivarius 24SMB and Streptococcus oralis 89a nasal spray after the first AOM episode. Active treatment consisted of 3 monthly courses: 2 puffs per nostril twice/day for a week. Group B showed a significant reduction of AOM episodes in comparison with group A (p<0.0001). Notably, all actively treated children with the highest AOM recurrence had a reduction of recurrence, whereas only 50% of the control group children had reduced RAOM (p<0.0001). Also, severity grade of AOM significantly diminished after the preventive bacteriotherapy (p<0.0001). In conclusion, the current retrospective and observational study demonstrated that S. salivarius 24SMB and S. oralis 89a nasal spray could be effective in the prevention of RAOM in a real-life setting.

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Contemporary Concepts in Management of Acute Otitis Media in Children

Cited by 57 publications

References 86 publications

Inflammation, infection, and allergy of upper airways: new insights from national and real-world studies

Inflammation, infection, and allergy of upper airways: new insights from national and real-world studies

Video‐otoscopy‐guided tympanostomy tube placement for treatment of middle ear effusion

Bacteriotherapy with <em>Streptococcus salivarius</em> 24SMB and <em>Streptococcus oralis</em> 89a nasal spray for preventing recurrent acute otitis media in children: a real-life clinical experience

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