Bacteriotherapy with <em>Streptococcus salivarius</em> 24SMB and <em>Streptococcus oralis</em> 89a nasal spray for preventing recurrent acute otitis media in children: a real-life clinical experience

Abstract

Recurrence of acute otitis media (RAOM) is a relevant issue in the clinical practice. “Bacteriotherapy” has been proposed as an option in children with RAOM. Streptococcus salivarius 24SMB nasal spray has been previously demonstrated to reduce the risk of acute otitis media (AOM) in otitis-prone children. The current retrospective and observational study aimed to confirm this outcome in a real-life setting, such as the common pediatric practice. Group A (108 children) served as control; group B (159 children) was treated with S. salivarius 24SMB and Streptococcus oralis 89a nasal spray after the first AOM episode. Active treatment consisted of 3 monthly courses: 2 puffs per nostril twice/day for a week. Group B showed a significant reduction of AOM episodes in comparison with group A (p<0.0001). Notably, all actively treated children with the highest AOM recurrence had a reduction of recurrence, whereas only 50% of the control group children had reduced RAOM (p<0.0001). Also, severity grade of AOM significantly diminished after the preventive bacteriotherapy (p<0.0001). In conclusion, the current retrospective and observational study demonstrated that S. salivarius 24SMB and S. oralis 89a nasal spray could be effective in the prevention of RAOM in a real-life setting.

A Comparison of Flavorless Electronic Cigarette-Generated Aerosol and Conventional Cigarette Smoke on the Planktonic Growth of Common Oral Commensal Streptococci

“…It is important to note that tobacco smoke promotes biofilm growth of oral pathogens, including P. gingivalis, and S. mutans [22,58,[61][62][63][64]. The three commensal species in this study have been shown to arrest the growth of common pathogens [16,17,65]. Furthermore, S. mitis can help promote the development of Th17 T cells that can cross-react with Streptococcus pneumoniae, enhancing the immune response against this pathogen and consequently leading to its clearance [66].…”

Bacteriotherapy with Streptococcus salivarius 24SMB and Streptococcus oralis 89a nasal spray for treatment of upper respiratory tract infections in children: a pilot study on short-term efficacy

“…With this regard, studies showed that the use of probiotic strains, acting as "friendly bacteria", in RRIs, offered great benefits for the host [15,22]. As regards to potential pathogens, Streptococcus salivarius and Streptococcus oralis species have been proven to be capable to promote the recolonization process and to reestablish microbial balance as well as to decrease the level of potential pathogens, therefore, reducing and preventing RRIs [18,23]. These findings were successively confirmed by the evidence that close correlations between the reduction of potential pathogens, the presence of commensal streptococci, and a lower incidence of RRIs were occurring among patients receiving probiotics treatment [18,23].…”

Inflammation, infection, and allergy of upper airways: new insights from national and real-world studies

“…If associated with vitamin D3, L reuteri provided more interesting outcomes [139]. Finally, as above discussed, bacteriotherapy, such as the administration of "good" bacteria (usually saprophytic), may be a promising approach in preventing respiratory infections as demonstrated in children with recurrent acute otitis media [140]. A preliminary study showed that bacteriotherapy could also prevent adenoid surgery [141].…”