Contamination of the Nebulization Systems Used in the Prophylaxis With Amphotericin B Nebulized in Lung Transplantation

Nebulized Liposomal Amphotericin B Prophylaxis for Aspergillus Infection in Lung Transplantation: Pharmacokinetics and Safety

“…The main drawbacks include poor adherence to treatment, because frequent administration is required, [12][13][14][15] and the potential for contamination of the nebulization system. 16 Other formulations of inhaled amphotericin B (lipid complex and liposomal amphotericin) have been proposed for prophylactic purposes, with promising results. [17][18][19][20] In some experimental models, nebulized liposomal amphotericin B (n-LAB) has been shown to be more effective 21 and long-lasting 22 than the conventional formulation.…”

No positive effect of rhdnase on the pulmonary colonization in children with cystic fibrosis

“…Secondly, by using rhDNAse better and increased sputum expectoration was established, increasing the chance to have PA positive cultures compared to spontaneous sputum expectoration. A third explanation for the rise of PA in the treatment group might be that the nebulization process increases the risk of PA contamination [30]. During nebulization there is a direct passage to the airways, which may increase the risk of inhalation of microorganisms such as PA.…”

Soluble squalamine tablets for the rapid disinfection of home nebulizers of cystic fibrosis patients

“…Cleaning and disinfection have been recommended to limit the risk of contamination [7]. Various methods for nebulizer disinfection have been proposed by different CF foundations.…”

“…Because nebulizers are frequently used by the patients for long periods of time, microbial contamination generally occurs. This contamination is a serious problem, leading to reduced nebulizer performance and increasing the risk of patient reinfection [1,[5][6][7]. Thus, to prevent the microbial contamination of nebulizers, these devices should be disinfected [8].…”