Contaminated Ventilator Air Flow Sensor Linked to<i>Bacillus cereus</i>Colonization of Newborns

Turabelidze, George; Gee, Jay E.; Hoffmaster, Alex R.; Manian, Farrin A.; Butler, Cindy; Byrd, David; Schildknecht, Stephanie; Hauser, Lina Chavez; Duncan, Mary; Ferrett, Rhonda; Evans, Dana; Talley, Crystal

doi:10.3201/eid1905.120239

Cited by 14 publications

(10 citation statements)

References 15 publications

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“…Indeed, B. cereus contamination is present and persistent in the hospital environment, and reported sources of infection in NICUs such as respiratory support equipment, umbilical catheterization, gastric feeding tubes, dried formulas, linens, heating, ventilation and air conditioning systems have been documented. 17,30,34,[37][38][39] However, B. cereus should not be considered only as an environmental contaminant because it can induce a delay in treatment that may compromise the clinical outcome.…”

Section: Discussionmentioning

confidence: 99%

Bacillus cereusinfection in neonates and the absence of evidence for the role of banked human milk: Case reports and literature review

Lewin

Quach

Rigourd

et al. 2019

Infect. Control Hosp. Epidemiol.

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Background:Banked human milk (BHM) has inherent infectious risks, even when pasteurized. Because of the ubiquity of Bacillus cereus in the environment and its ability to resist the Holder pasteurization process, there is a concern that BHM might lead to severe B. cereus infections.Objective:We reviewed observed and published cases to determine the potential causal role of BHM as the source of these infections.Methods:Two infants in the province of Québec (Canada) developed a B. cereus neonatal infection, and both had received BHM. We conducted bacteriological studies to compare clinical isolates and those found in these cases.Results:After extended culture of BHM retention lots, B. cereus was found to have been involved in batches related to the first case. However, molecular typing showed that the strain was different from the clinical isolate, therefore excluding BHM as the source of contamination. In the second case, a Brevibacillus spp was isolated, a species distinct from the clinical isolate.Conclusion:Based on these cases and others reported in the literature, a causal link between B. cereus contaminated BHM and preterm neonatal infection has never been documented. Therefore, the risk that BHM can cause this infection remains theoretical. Given the widespread presence of B. cereus in the hospital environment and its capacity to resist standard cleaning procedures, it seems likely that airborne or direct or indirect contact are the main sources of most, if not all, cases of severe B. cereus neonatal infections, even in babies exposed to BHM.

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Section: Discussionmentioning

confidence: 99%

Bacillus cereusinfection in neonates and the absence of evidence for the role of banked human milk: Case reports and literature review

Lewin

Quach

Rigourd

et al. 2019

Infect. Control Hosp. Epidemiol.

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“…To prevent the formation of bacterial biofilms inside the valves, a 1.75 mm filament made from a novel material for 3D printing was developed. The space inside the valves is exposed to the flow of warm and/or humid air which is often contaminated by exhalations (Motamedi et al, 2017;Turabelidze et al, 2013…”

Section: D-printing Of Plastic Partsmentioning

confidence: 99%

Q‐VENT—A novel device for emergency ventilation of the lungs in patients with respiratory failure due to diseases such as COVID‐19

et al. 2020

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At the end of 2019, the China Office of the (WHO) was informed of pneumonia cases of unknown cause detected in Wuhan City, Hubei Province. The Chinese authorities identified and isolated a new type of RNA virus belonging to the subfamily of the coronaviruses, later designated as SARS-CoV-2, and they shared the genetic sequence of the novel coronavirus (2019-nCoV) for countries to use in developing specific diagnostic kits (World Health Organization). China responded by informing the WHO of the outbreak and sharing sequence information with the international community after the discovery of the causative agent (Munster et al., 2020). Since its discovery, the virus has spread globally, leading to hundreds of thousands of deaths and creating an enormous impact on

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“…However, recently outbreaks of severe and lethal Bacillus infections have been widely reported, especially diseases related with Bacillus cereus at NICUs [75,76]. Several of these infections resulted of contamination of respiratory equipment [76–78]. Therefore, contamination with this genus should not be routinely neglected.…”

Section: Supplementary Textmentioning

confidence: 99%

Microbial communities profiling in intensive care units expose limitations in current sanitary standards

Ribeiro

Lopes

Kishi

et al. 2019

Preprint

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Contaminated Ventilator Air Flow Sensor Linked toBacillus cereusColonization of Newborns

Cited by 14 publications

References 15 publications

Bacillus cereusinfection in neonates and the absence of evidence for the role of banked human milk: Case reports and literature review

Bacillus cereusinfection in neonates and the absence of evidence for the role of banked human milk: Case reports and literature review

Q‐VENT—A novel device for emergency ventilation of the lungs in patients with respiratory failure due to diseases such as COVID‐19

Microbial communities profiling in intensive care units expose limitations in current sanitary standards

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