Contactless, programmable acoustofluidic manipulation of objects on water

Zhang, Peiran; Chen, Chuyi; Guo, Feng; Philippe, Julien; Gu, Yuyang; Tian, Zhenhua; Bachman, Hunter; Ren, Liqiang; Yang, Shujie; Zhong, Zhanwei; Huang, Po Hsun; Katsanis, Nicholas; Chakrabarty, Krishnendu; Huang, Tony Jun

doi:10.1039/c9lc00465c

Cited by 36 publications

(50 citation statements)

References 49 publications

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“…divide SAW-based tweezers into two subcategories where we first discuss the devices that operate on static or enclosed reservoirs as the target workspace i.e. SAW-I devices [46][47][48][49][50][51][52]. Secondly, we delve into microfluidic SAW devices i.e.…”

Section: Passive Agents and Actuation Strategiesmentioning

confidence: 99%

Contactless acoustic micro/nano manipulation: a paradigm for next generation applications in life sciences

2020

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Acoustic actuation techniques offer a promising tool for contactless manipulation of both synthetic and biological micro/nano agents that encompass different length scales. The traditional usage of sound waves has steadily progressed from mid-air manipulation of salt grains to sophisticated techniques that employ nanoparticle flow in microfluidic networks. State-of-the-art in microfabrication and instrumentation have further expanded the outreach of these actuation techniques to autonomous propulsion of micro-agents. In this review article, we provide a universal perspective of the known acoustic micromanipulation technologies in terms of their applications and governing physics. Hereby, we survey these technologies and classify them with regards to passive and active manipulation of agents. These manipulation methods account for both intelligent devices adept at dexterous non-contact handling of micro-agents, and acoustically induced mechanisms for self-propulsion of micro-robots. Moreover, owing to the clinical compliance of ultrasound, we provide future considerations of acoustic manipulation techniques to be fruitfully employed in biological applications that range from label-free drug testing to minimally invasive clinical interventions.

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Section: Passive Agents and Actuation Strategiesmentioning

confidence: 99%

Contactless acoustic micro/nano manipulation: a paradigm for next generation applications in life sciences

2020

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“…However, this isotonic solution cannot serve as a cell culture solution and the cells can only remain active for several minutes. Although this isotonic solution has no negative effect on the application of AC electrokinetic-based microfluidics in bio-related fields, it may impede the integration of this mechanism with other fashionable micro/nano-robotic manipulation tools-such as AFM [107][108][109], scanning ion conductance microscopy [110][111][112], and acoustic tweezers [113][114][115]-to rapidly and simultaneously acquire the intrinsic properties of cells. The integration of DEP with AFM was demonstrated to be capable of manipulating and assembling nanoparticles accurately [116][117][118].…”

Section: Conclusion and Prospectsmentioning

confidence: 99%

Determination of Dielectric Properties of Cells using AC Electrokinetic-based Microfluidic Platform: A Review of Recent Advances

Yang

Wang

et al. 2020

Micromachines

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Cell dielectric properties, a type of intrinsic property of cells, can be used as electrophysiological biomarkers that offer a label-free way to characterize cell phenotypes and states, purify clinical samples, and identify target cancer cells. Here, we present a review of the determination of cell dielectric properties using alternating current (AC) electrokinetic-based microfluidic mechanisms, including electro-rotation (ROT) and dielectrophoresis (DEP). The review covers theoretically how ROT and DEP work to extract cell dielectric properties. We also dive into the details of differently structured ROT chips, followed by a discussion on the determination of cell dielectric properties and the use of these properties in bio-related applications. Additionally, the review offers a look at the future challenges facing the AC electrokinetic-based microfluidic platform in terms of acquiring cell dielectric parameters. Our conclusion is that this platform will bring biomedical and bioengineering sciences to the next level and ultimately achieve the shift from lab-oriented research to real-world applications.

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“…The frequency and phase can be changed by chirped Interdigital Transducers (IDTs) to change the field, which means the dynamic field devices. (Republished with permission of the National Academy of Sciences from reference [13] Copyright © National Academy of Sciences 2014;) (d) A new kind of SAW operation method proposed by Zhang et al [50]. The IDTs with different shapes compared with the other systems are placed at the substrate of the operating plane in an array.…”

Section: Manipulation By Sawmentioning

confidence: 99%

“…The IDTs with different shapes compared with the other systems are placed at the substrate of the operating plane in an array. (Republished with permission of the Royal Society of Chemistry from reference [50]. Copyright © The Royal Society of Chemistry 2019; permission conveyed through Copyright Clearance Center, Inc.) TSAW devices are the most common in-planar micromanipulation method, and have been maturely applied in microfluidic systems and lab-on-a-chip.…”

Section: Manipulation By Sawmentioning

confidence: 99%

“…In recent years, new solutions have emerged that combine TSAW and SSAW. In the system proposed by Zhang et al [50], the transducers are smaller units that can be controlled separately by the upper controller. In this work, the authors used the mixed effect of ARF and acoustic streaming in the water layer to push the floating object following the directions of SAW propagation.…”

Section: Ssaw Devicesmentioning

confidence: 99%

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Advances in Micromanipulation Actuated by Vibration-Induced Acoustic Waves and Streaming Flow

et al. 2020

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The use of vibration and acoustic characteristics for micromanipulation has been prevalent in recent years. Due to high biocompatibility, non-contact operation, and relatively low cost, the micromanipulation actuated by the vibration-induced acoustic wave and streaming flow has been widely applied in the sorting, translating, rotating, and trapping of targets at the submicron and micron scales, especially particles and single cells. In this review, to facilitate subsequent research, we summarize the fundamental theories of manipulation driven by vibration-induced acoustic waves and streaming flow. These methods are divided into two types: actuated by the acoustic wave, and actuated by the steaming flow induced by vibrating geometric structures. Recently proposed representative vibroacoustic-driven micromanipulation methods are introduced and compared, and their advantages and disadvantages are summarized. Finally, prospects are presented based on our review of the recent advances and developing trends.

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Contactless, programmable acoustofluidic manipulation of objects on water

Abstract: Immersed interdigital transducer array enables contactless, programmable manipulation floating objects on water via acoustofluidics.

Cited by 36 publications

References 49 publications

Contactless acoustic micro/nano manipulation: a paradigm for next generation applications in life sciences

Contactless acoustic micro/nano manipulation: a paradigm for next generation applications in life sciences

Determination of Dielectric Properties of Cells using AC Electrokinetic-based Microfluidic Platform: A Review of Recent Advances

Advances in Micromanipulation Actuated by Vibration-Induced Acoustic Waves and Streaming Flow

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