Contact Urticaria from Curcumin

Liddle, M.; Hull, Christopher M.; Liu, Clive; Powell, D. L.

doi:10.2310/6620.2006.06004

Cited by 63 publications

(37 citation statements)

References 5 publications

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“…36 Large doses of curcumin can cause gastrointestinal problems, including diarrhea and constipation and, in rare cases, contact dermatitis. 37,38 In addition, curcumin disrupts the p53 tumor-suppressor pathway in colon cancer cells, and the potential exists for carcinogenic effects. 39 Syk inhibition has previously been shown to result in the reduction of allergic airway inflammation.…”

Section: Discussionmentioning

confidence: 99%

Curcumin, a constituent of curry, suppresses IgE-mediated allergic response and mast cell activation at the level of Syk

Lee

Kim

et al. 2008

Journal of Allergy and Clinical Immunology

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Section: Discussionmentioning

confidence: 99%

Curcumin, a constituent of curry, suppresses IgE-mediated allergic response and mast cell activation at the level of Syk

Lee

Kim

et al. 2008

Journal of Allergy and Clinical Immunology

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“…Though a combination of neem and turmeric powder was effective in human scabies, in vitro studies and further human studies are needed . Turmeric can stain skin and may cause contact urticaria and allergic contact dermatitis …”

Section: Essential Oils and Plant Extractsmentioning

confidence: 99%

Tackling scabies: novel agents for a neglected disease

2018

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The scabies mite, Sarcoptes scabiei var hominis, is an obligate ectoparasite of humans. It has been a source of distress for humanity since antiquity. The troublesome mite is emerging triumphant over current acaricidal agents with reports of emerging resistance and treatment failures. Scabies in endemic areas and crusted scabies offer additional management challenges. Exploration of indigenous plants and better understanding of mite biology and pathogenesis provide opportunities for the development of novel agents for this common pest. We review the recent diverse approaches to scabies, including the use of novel plant products with a better safety profile, translating the use of moxidectin from veterinary practice to human scabies, vaccination, immunotherapy, and development of drugs that directly target mite molecules.

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“…For instance, turmeric-induced skin allergies have been reported among workers in turmeric factories. Cases of allergic contact dermatitis and contact urticaria from curcumin mediated by 2 different mechanisms have been reported (315). There are also similar reports with ginger, nutmeg, and oregano (316).…”

Section: Limitations and Adverse Effects Of Spicementioning

confidence: 99%

Cancer Cell Signaling Pathways Targeted by Spice-Derived Nutraceuticals

Sung

Prasad

Yadav

et al. 2012

Nutrition and Cancer

171

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Extensive research within the last half a century has revealed that cancer is caused by dysregulation of as many as 500 different gene products. Most natural products target multiple gene products and thus are ideally suited for prevention and treatment of various chronic diseases, including cancer. Dietary agents such as spices have been used extensively in the Eastern world for a variety of ailments for millennia, and five centuries ago they took a golden journey to the Western world. Various spice-derived nutraceuticals, including 1′-acetoxychavicol acetate, anethole, capsaicin, car-damonin, curcumin, dibenzoylmethane, diosgenin, eugenol, gambogic acid, gingerol, thymoquinone, ursolic acid, xanthohumol, and zerumbone derived from galangal, anise, red chili, black cardamom, turmeric, licorice, fenugreek, clove, kokum, ginger, black cumin, rosemary, hop, and pinecone ginger, respectively, are the focus of this review. The modulation of various transcription factors, growth factors, protein kinases, and inflammatory mediators by these spice-derived nutraceuticals are described. The anticancer potential through the modulation of various targets is also the subject of this review. Although they have always been used to improve taste and color and as a preservative, they are now also used for prevention and treatment of a wide variety of chronic inflammatory diseases, including cancer.

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Contact Urticaria from Curcumin

Cited by 63 publications

References 5 publications

Curcumin, a constituent of curry, suppresses IgE-mediated allergic response and mast cell activation at the level of Syk

Curcumin, a constituent of curry, suppresses IgE-mediated allergic response and mast cell activation at the level of Syk

Tackling scabies: novel agents for a neglected disease

Cancer Cell Signaling Pathways Targeted by Spice-Derived Nutraceuticals

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