Curcumin, a constituent of curry, suppresses IgE-mediated allergic response and mast cell activation at the level of Syk

Lee, Jun Ho; Kim, Jie Wan; Ko, Na Young; Mun, Se Hwan; Her, Erk; Kim, Bo Kyung; Han, Jeung Whan; Lee, Hoi Young; Beaven, Michael A.; Kim, Young Mi; Choi, Wahn Soo

doi:10.1016/j.jaci.2007.12.1160

Cited by 88 publications

(81 citation statements)

References 43 publications

(53 reference statements)

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“…Possible Molecular Targets of Curcumin (34) Regarding the mechanism of action of curcuminoids, Lee et al reported that 34 inhibited the activity of Syk which plays a pivotal role in FcεRI-mediated degranulation of mast cells. 62) However, a previous study 58) and our results, showing that 34 inhibited calcium ionophore A23187-stimulated degranulation, suggested that other mechanisms such as degranulation mechanisms after Ca 2+ influx as well as the inhibition of Syk were involved, as for flavonoids and stilbenes. …”

Section: Structural Requirements Of Curcuminoids For Thecontrasting

confidence: 52%

Degranulation Inhibitors from Medicinal Plants in Antigen-Stimulated Rat Basophilic Leukemia (RBL-2H3) Cells

2016

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Mast cells and basophils play important roles in both immediate-and late-phase reactions of type 1 allergy. Histamine, which is released from mast cells and basophils stimulated by an antigen or degranulation inducers, is usually determined as a degranulation marker in experiments on immediate allergic reactions in vitro. β-Hexosaminidase is also stored in secretory granules of the cells and is released concomitantly with histamine when the cells are immunologically activated, and recently this enzyme activity in the medium has been used as a marker of the degranulation. In this paper, we review our studies on the search for degranulation inhibitors, such as flavonoids, stilbenes, and curcuminoids, from medicinal plants using rat basophilic leukemia (RBL-2H3) cells.

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Section: Structural Requirements Of Curcuminoids For Thecontrasting

confidence: 52%

Degranulation Inhibitors from Medicinal Plants in Antigen-Stimulated Rat Basophilic Leukemia (RBL-2H3) Cells

2016

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“…9,10 In the past few years, studies have shown that curcumin has potential therapeutic value in a variety of chronic diseases, including asthma. 11 Previous studies have shown that curcumin inhibited ovalbumin (OVA)-induced airway constriction and airway hyperreactivity and airway inflammation in a murine model of asthma through suppression of nitrous oxide.…”

mentioning

confidence: 99%

Enhanced bioavailability and efficiency of curcumin for the treatment of asthma by its formulation in solid lipid nanoparticles

Wang

Zhu²,

Xie³

et al. 2012

IJN

172

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Curcumin has shown considerable pharmacological activity, including anti-inflammatory, but its poor bioavailability and rapid metabolization have limited its application. The purpose of the present study was to formulate curcumin-solid lipid n anoparticles (curcumin-SLNs) to improve its therapeutic efficacy in an ovalbumin (OVA)-induced allergic rat model of asthma. A solvent injection method was used to prepare the curcumin-SLNs. Physiochemical properties of curcumin-SLNs were characterized, and release experiments were performed in vitro. The pharmacokinetics in tissue distribution was studied in mice, and the therapeutic effect of the formulation was evaluated in the model. The prepared formulation showed an average size of 190 nm with a zeta potential value of −20.7 mV and 75% drug entrapment efficiency. X-ray diffraction analysis revealed the amorphous nature of the encapsulated curcumin. The release profile of curcumin-SLNs was an initial burst followed by sustained release. The curcumin concentrations in plasma suspension were significantly higher than those obtained with curcumin alone. Following administration of the curcumin-SLNs, all the tissue concentrations of curcumin increased, especially in lung and liver. In the animal model of asthma, curcumin-SLNs effectively suppressed airway hyperresponsiveness and inflammatory cell infiltration and also significantly inhibited the expression of T-helper-2-type cytokines, such as interleukin-4 and interleukin-13, in bronchoalveolar lavage fluid compared to the asthma group and curcumin-treated group. These observations implied that curcumin-SLNs could be a promising candidate for asthma therapy.

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“…Therefore, further efforts are necessary to develop new drugs with fewer side effects for treatment of RA. Although the exact mechanisms that contribute to RA pathogenesis largely remain unknown, it is well-established that the hyperplasia of FLS and the infiltration of T cells, B cells, dendritic cells, and mast cells in joint synovial tissues and their production of proinflammatory mediators such as TNF-α and IL-1 are critical in the pathogenesis of RA (34). Among these cells, FLS contributed principally to the pathological process of RA (4,5).…”

Section: Discussionmentioning

confidence: 99%

“…Recently, it was reported that curcumin inhibits the activation of mast cells (34), one of the infiltrating cells during the development of RA (35). Those effects of curcumin may additively or synergistically ameliorate the pathogenic process of RA.…”

Section: Discussionmentioning

confidence: 99%

Oral Administration of Curcumin Suppresses Production of Matrix Metalloproteinase (MMP)-1 and MMP-3 to Ameliorate Collagen-Induced Arthritis: Inhibition of the PKCδ/JNK/c-Jun Pathway

Mun

Kim

et al. 2009

J Pharmacol Sci

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Abstract. We investigated whether oral administration of curcumin suppressed type II collagen-induced arthritis (CIA) in mice and its effect and mechanism on matrix metalloproteinase (MMP)-1 and MMP-3 production in CIA mice, RA fibroblast-like synoviocytes (FLS), and chondrocytes. CIA in mice was suppressed by oral administration of curcumin in a dose-dependent manner. Macroscopic observations were confirmed by histological examinations. Histological changes including infiltration of immune cells, synovial hyperplasia, cartilage destruction, and bone erosion in the hind paw sections were extensively suppressed by curcumin. The histological scores were consistent with clinical arthritis indexes. Production of MMP-1 and MMP-3 were inhibited by curcumin in CIA hind paw sections and tumor necrosis factor (TNF)-α-stimulated FLS and chondrocytes in a dose-dependent manner. As for the mechanism, curcumin inhibited activating phosphorylation of protein kinase Cδ (PKCδ) in CIA, FLS, and chondrocytes. Curcumin also suppressed the JNK and c-Jun activation in those cells. This study suggests that the suppression of MMP-1 and MMP-3 production by curcumin in CIA is mediated through the inhibition of PKCδ and the JNK /c-Jun signaling pathway.

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Curcumin, a constituent of curry, suppresses IgE-mediated allergic response and mast cell activation at the level of Syk

Cited by 88 publications

References 43 publications

Degranulation Inhibitors from Medicinal Plants in Antigen-Stimulated Rat Basophilic Leukemia (RBL-2H3) Cells

Degranulation Inhibitors from Medicinal Plants in Antigen-Stimulated Rat Basophilic Leukemia (RBL-2H3) Cells

Enhanced bioavailability and efficiency of curcumin for the treatment of asthma by its formulation in solid lipid nanoparticles

Oral Administration of Curcumin Suppresses Production of Matrix Metalloproteinase (MMP)-1 and MMP-3 to Ameliorate Collagen-Induced Arthritis: Inhibition of the PKCδ/JNK/c-Jun Pathway

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