Contact sensitization to (meth)acrylates in three construction workers

Self Cite

BackgroundAllergic contact dermatitis from (meth)acrylic monomers (ACDMA) in manicure products is increasing.ObjectiveTo evaluate the prognosis, work performance impairment and sequelae of a cohort of beauticians and manicure consumers with ACDMA sensitized from the exposure to manicure products.MethodsWe conducted a telephone survey with patients diagnosed with ACDMA.ResultsOne hundred and six patients were evaluated, including 75 (70.8%) beauticians and 31 (29.2%) consumers. All were women with a mean age of 39 (19–62). Thirty‐seven of 75 beauticians (49.3%) continued to work. Twenty‐seven of 106 (25.5%) patients continued to use manicure products with (meth)acrylates regularly. Seventeen of 51 (33.3%) patients who discontinued the exposure described ongoing nail/periungual changes. Nine of 58 (15.5%) patients who required dental restoration, orthodontic or occlusal splint materials recalled reactions from them; and, 25 of 96 (26%) who used sanitary napkins recalled intolerance to them starting after the diagnosis of ACDMA. Fifteen of 25 (60%) discontinued the use of sanitary napkins.Conclusion49.3% beauticians continued to work; most patients stopped wearing acrylic manicure materials; reactions from dental materials were not uncommon, however, removal of dental materials was never required; and, reactions to sanitary napkins developing after the diagnosis of ACDMA were common most leading to discontinuation of use.

Section: Dental Materialsmentioning

confidence: 99%

Prognosis and sequelae of meth(acrylate) sensitization in beauticians and consumers of manicure materials

Gatica‐Ortega,

Rodríguez‐Lago,

Beneyto

et al. 2023

Self Cite

“…All recalled worsening of their reactions secondary to performing work tasks and improvement during holidays. 25 Five patients recalled genital pruritus or eczema from superabsorbent materials (sanitary napkins and incontinence pads). Two of them never used manicure materials with acrylates (previously published).…”

Section: Discussionmentioning

confidence: 99%

2‐Hydroxyethyl methacrylate (2‐HEMA) sensitization, a global epidemic at its peak in Spain?

Gatica‐Ortega,

Pastor‐Nieto,

Giménez‐Arnau

et al. 2024

BackgroundA global epidemic of allergic contact dermatitis to (meth)acrylates has been described in relation to the widespread use of manicure products.ObjectivesTo evaluate the frequency of sensitization to 2‐hydroxyethyl methacrylate (2‐HEMA) among consecutively patch tested patients with eczema in Spain; the percentage of current relevance; the MOAHLFA index; and, the potential sources of exposure to (meth)acrylates.MethodsFrom January 2019 to December 2022, 2‐HEMA 2% pet. was prospectively patch tested in 24 REIDAC (Spanish Allergic Contact Dermatitis Registry) centres.ResultsSix thousand one hundred thirty‐four patients were consecutively patch tested with 2‐HEMA 2% pet. 265/6134 (4.3%) were positive. Positive reactions of current relevance were identified to involve 184/265 (69%). The efficiency (number of patch tests needed to detect relevant positive patch test reactions) was 34 (6134/184). The variable ‘occupational’ was found to be significantly associated with a higher risk for relevant positive reactions to 2‐HEMA (OR: 10.9; 95% CI: 8.1–14.9).Conclusion(Meth)acrylate sensitization is a prevalent health issue in Spain. 2‐HEMA 2% pet. has been identified to be a highly effective (meth)acrylate allergy marker in the GEIDAC baseline series. The responsible authorities should implement policies guaranteeing accurate labelling of industrial, medical, and consumer materials while ensuring the enforcement of said labelling through appropriate legal means.

“…Individuals who acquire contact allergy to (meth)acrylates in nail cosmetics may subsequently also develop allergic reactions from dental materials, knee prostheses, sanitary napkins, glucose sensors and very likely other materials and products. 15 Several investigators, therefore, have made a plea for stricter regulation of these products to prevent this avoidable problem generated in the pursuit of fashion. 2,4,6,16 In response to the large numbers of patients with contact allergy to HEMA in nail cosmetics and dermatologists' calls to action, in November 2020, in the European Union, the must be stated on the package of nail products containing HEMA, di-HEMA TMHDC or both.…”

Section: Discussionmentioning

confidence: 99%

“…Contact allergy to acrylate‐containing nail cosmetics can have serious consequences for patients, which may not be limited to problems with or being unable to work as a nail technician or experiencing dermatitis or nail disorders from using nail cosmetics. Individuals who acquire contact allergy to (meth)acrylates in nail cosmetics may subsequently also develop allergic reactions from dental materials, knee prostheses, sanitary napkins, glucose sensors and very likely other materials and products 15 …”

Section: Discussionmentioning

confidence: 99%

Contact allergy to acrylate‐containing nail cosmetics: A retrospective 8‐year study

Steunebrink,

de Groot,

Rustemeyer

2023

BackgroundOver the last 10 years, allergic contact dermatitis (ACD) from acrylate‐containing nail cosmetics (acrylic nails, gel nails, gel nail polish) has been reported repeatedly.ObjectivesTo investigate the frequency and clinical features of ACD in nail cosmetics in a university hospital in Amsterdam, The Netherlands.Patients and MethodsA retrospective study in patients diagnosed with ACD from acrylate‐containing nail cosmetics at the Amsterdam University Medical Centers between January 2015 and August 2023.ResultsSixty‐seven patients, all women, were diagnosed with ACD from nail cosmetics, representing 1.6% of all individuals and 2.3% of all women patch tested in this period. Sixty‐five of sixty‐seven (97%) subjects had a positive patch test to 2‐hydroxyethyl methacrylate (HEMA). Forty‐nine patients (73%) were consumers and 18 (27%) were professional nail stylists. The sites most frequently affected with dermatitis were the fingers (79%), hands (40%) and the head and/or neck. Avoidance of contact with acrylate‐containing products resulted in complete clearing of dermatitis in 80% of patients.ConclusionsACD from acrylate‐containing nail cosmetics is frequent in women patch tested in Amsterdam. Nearly all were identified by a positive patch test to 2‐hydroxyethyl methacrylate in the (meth)acrylate series or the European baseline series.