Contact sensitization to ingredients of dental materials and cosmetics in dental students: a pilot study

Abstract

Objective: The aim of this study was to evaluate the rate of contact sensitization to selected cosmetic allergens, i.e. ingredients of dental materials, in students of dental medicine and dental patients.Methods: A total of 50 participants were included in the study: 40 students of dental medicine exposed to the studied allergens during the course of practical education; and 10 randomly selected dental patients without occupational exposure to the investigated substances served as a control group. All of them were patch-tested with colophonium, myroxylon pereirae resin, paraben mix, fragrance mix I, isopropyl myristate, triclosan, polysorbate 80, compositae mix II, and hydroperoxides of limonene.Results: The sensitization rates for colophonium and polysorbate 80 were the highest. For the group of dental students, we established significantly higher sensitization rate for colophonium compared to the ones for myroxylon pereirae resin and hydroperoxides of limonene (χ 2 = 4.93; p = 0.026), paraben mix (χ 2 = 3.6; p = 0.05), isopropyl myristate (χ 2 = 6.56; p = 0.01), and triclosan (χ 2 = 8.5; p < 0.001); and to polysorbate 80 compared to the ones for myroxylon pereirae resin and hydroperoxides of limonene (χ 2 = 3.97; p = 0.046), isopropyl myristate (χ 2 = 5.47; p = 0.02) and triclosan (χ 2 = 7.34; p = 0.007). Significantly increased concomitant sensitization rate to compositae mix and to hydroperoxides of limonene was established (χ 2 = 12.55; p < 0.001). Generally, the incidence of concomitant sensitization to the studied allergens in the whole studied population was high.Conclusions: Colophonium and polysorbate 80 could be outlined as sensitizers of paramount importance for both dental students and dental patients. We consider the major importance of exposure to colophonium during the course of practical education in dentistry for the onset of the sensitization. Sensitization to compositae mix was observed only among dental students. We consider the leading role of consumer exposure for the onset of the sensitization to triclosan and to hydroperoxides of limonene. Unexpected and unreported reactions of concomitant sensitization were observed.

Common contributing factors to COVID-19 and inflammatory bowel disease

“…Significantly increased concomitant sensitization rate to compositae mix and to hydroperoxides of limonene was established (χ2 = 12.55; p < 0.001). Generally, the incidence of concomitant sensitization to the studied allergens in the whole studied population was high…..Colophonium and polysorbate 80 could be outlined as sensitizers of paramount importance for both dental students and dental patients.” [ 102 ]…”

COVID-19 Disease, Women’s Predominant Non-Heparin Vaccine-Induced Thrombotic Thrombocytopenia and Kounis Syndrome: A Passepartout Cytokine Storm Interplay

“…D. Younger-aged women, who routinely use creams, ointments, lotions, and other cosmetics that contain polysorbate, could have been earlier sensitized to polysorbate and will likely develop adverse reactions when exposed to the same agent. Furthermore, polysorbate is also an ingredient in various dental materials and contact sensitization in dental patients has been proven [124]. Indeed, it is estimated that 1-5.4% of the population is already sensitized to cosmetics or cosmetic ingredients [124].…”

“…Furthermore, polysorbate is also an ingredient in various dental materials and contact sensitization in dental patients has been proven [124]. Indeed, it is estimated that 1-5.4% of the population is already sensitized to cosmetics or cosmetic ingredients [124]. We suggest, therefore, that atopic subjects and patients with a previous allergic history should carefully look at SPC (Special Product Characteristics) of their used cosmetics for any containing polysorbate excipient, and also for any other ingredient cross-reacting with polysorbate such as polyethylene glycol product.…”

Acute Myocardial Infarction Within 24 Hours After COVID-19 Vaccination: Is Kounis Syndrome the Culprit?

“…It is estimated that 1% to 5.4% of the population is already sensitized to cosmetics or cosmetic ingredients. 10 Free polysorbate oncology medications are already in the market. 11 Alternatives to these excipients, such as alkylsaccharides, are promising agents because they can reduce immunogenicity, improve stability, suppress oxidative damage problems, and may prevent thrombotic and cardiovascular events.…”