2020
DOI: 10.3390/app10155151
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Contact Lenses as Drug Delivery System for Glaucoma: A Review

Abstract: Glaucoma is an optical neuropathy associated to a progressive degeneration of retinal ganglion cells with visual field loss and is the main cause of irreversible blindness in the world. The treatment has the aim to reduce intraocular pressure. The first therapy option is to instill drugs on the ocular surface. The main limitation of this is the reduced time of the drug staying on the cornea. This means that high doses are required to ensure its therapeutic effect. A drug-loaded contact lens can diffuse into th… Show more

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Cited by 25 publications
(28 citation statements)
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References 153 publications
(224 reference statements)
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“…Recently, Peral et al detailed technical aspects of a CL drug-delivery system in glaucoma, highlighting the increased drug bioavailability [21]. Simultaneously, administering a lower drug dose, adverse events' frequency and severity were reduced [21].…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…Recently, Peral et al detailed technical aspects of a CL drug-delivery system in glaucoma, highlighting the increased drug bioavailability [21]. Simultaneously, administering a lower drug dose, adverse events' frequency and severity were reduced [21].…”
Section: Discussionmentioning
confidence: 99%
“…Recently, Peral et al detailed technical aspects of a CL drug-delivery system in glaucoma, highlighting the increased drug bioavailability [21]. Simultaneously, administering a lower drug dose, adverse events' frequency and severity were reduced [21]. In particular, only 20% of the drug dose was required to produce a similar therapeutic effect with CL drug-delivery systems compared to the dose needed with eyedrops delivery systems [65].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…There are two main groups of contact lenses depending on the designed material: soft contact lenses–made of hydrogel or silicone hydrogel polymers, and rigid gas-permeable contact lenses (RGP) [ 28 ]. The soft materials for use as drug delivery systems are of more interest because of their hydrophilic properties, biocompatibility, and comfort of use [ 34 , 35 ].…”
Section: Contact Lenses As Drug Delivery Systemsmentioning
confidence: 99%
“…The dynamic of this research is evidenced by the number of publications that appear in scientific journals. Table 1 summarises the review papers that have been published in recent years [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 ].…”
Section: Introductionmentioning
confidence: 99%