Contact Lens-Induced Regression of Lisch Epithelial Corneal Dystrophy

Lisch, Walter; Wasielica‐Poslednik, Joanna; Lisch, Christina; Saikia, Parykshit; Pitz, Susanne

doi:10.1097/ico.0b013e3181aabefe

Cited by 21 publications

(16 citation statements)

References 13 publications

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“…Polymerized HEMA has been used as a main component of glass-ionomer cements. Poly-HEMA has been successfully developed since 1960 as a biocompatible material and used in different fields of medicine including ophthalmology, cardiovascular, plastic surgery and otolaryngology [27][28][29]. Also, it has a widespread usage as an adhesive and diluents in dental materials because it facilitates self-adhesion to mineral phase of dental tissues [30] and has a tendency to interact with HA particles which results in improvement of matrix/filler coherency [31].…”

Section: Discussionmentioning

confidence: 98%

Development of strong and bioactive calcium phosphate cement as a light-cure organic–inorganic hybrid

Barounian

Hesaraki

Kazemzadeh

2012

J Mater Sci: Mater Med

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In this research, light cured calcium phosphate cements (LCCPCs) were developed by mixing a powder phase (P) consisting of tetracalcium phosphate and dicalcium phosphate and a photo-curable resin phase (L), mixture of hydroxyethylmethacrylate (HEMA)/poly acrylic-maleic acid at various P/L ratios of 2.0, 2.4 and 2.8 g/mL. Mechanical strength, phase composition, chemical groups and microstructure of the cured cements were evaluated at pre-set times, i.e. before and after soaking in simulated body fluid (SBF). The proliferation of Rat-derived osteoblastic cells onto the LCCPCs as well as cytotoxicity of cement extracts were determined by cell counting and 3-{4,5-dimethylthiazol-2yl}-2,5-diphenyl-2H-tetrazolium bromide assay after different culture times. It was estimated from Fourier transforming infrared spectra of cured cements that the setting process is ruled by polymerization of HEMA monomers as well as formation of calcium poly-carboxylate salts. Microstructure of the cured cements consisted of calcium phosphate particles surrounded by polymerized resin phase. Formation of nano-sized needlelike calcium phosphate phase on surfaces of cements with P/L ratios of 2.4 and 2.8 g/mL was confirmed by scanning electron microscope images and X-ray diffractometry (XRD) of the cured specimen soaked in SBF for 21 days. Also, XRD patterns revealed that the formed calcium phosphate layer was apatite phase in a poor crystalline form. Biodegradation of the cements was confirmed by weight loss, change in molecular weight of polymer and morphology of the samples after different soaking periods. The maximum compressive strength of LCCPCs governed by resin polymerization and calcium polycarboxylate salts formation was about 80 MPa for cement with P/L ratio of 2.8 g/mL, after incubation for 24 h. The strength of all cements decreased by decreasing P/L ratio as well as increasing soaking time. The preliminary cell studies revealed that LCCPCs could support proliferation of osteoblasts cultured on their surfaces and no cytotoxic effect was observed for the extracts of them.

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Section: Discussionmentioning

confidence: 98%

Development of strong and bioactive calcium phosphate cement as a light-cure organic–inorganic hybrid

Barounian

Hesaraki

Kazemzadeh

2012

J Mater Sci: Mater Med

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“…Reports by Robin et al, 3 Charles et al, 4 Alvarez-Fischer et al, 5 and Lisch et al 6 have described additional cases. Treatment options consisted of topical therapy (lubricants and steroids), epithelial scraping, and contact lenses, with mostly limited success because recurrence is common.…”

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confidence: 94%

Treatment of Lisch Corneal Dystrophy With Photorefractive Keratectomy and Mitomycin C

Wessel

Sarkar

Jakobiec

et al. 2011

Cornea

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“…15 Epiteli tutan Lisch kornea distrofisinde 1 ila 3 ay yumuşak kontakt lens kullanılması sonrası görmede artma, santral kornea opasifikasyonunda azalma bildirmişlerdir. Bu düzelme kontakt lense bağlı kornea epitelindeki azalmaya bağlanmıştır.…”

Section: Discussionunclassified

Kornea Opasitelerinde Silikon Hidrojel Kontakt Lens Uygulamasının Yüksek Sıralı Kornea Aberasyonları ve Görme Kalitesi Üzerine Etkisi

...

2012

Tjo

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Amaç: Çeşitli nedenlere bağlı kornea opasitesi olan hastalarda silikon hidrojel kontakt lensler ile kornea yüksek dereceli aberasyonları ve görme kalitesi değişikliklerinin değerlendirilmesi. Ge reç ve Yön tem: Kornea opasitesi bulunan 13 hastanın 15 gözü çalışmaya dahil edildi. Oftalmolojik muayenede tüm hastaların kontakt lens uygulaması öncesi ve sonrasında görme keskinliği Snellen eşeli ile ve kontrast hassasiyeti Bailey-Lowie eşeli ile harf olarak ölçüldü. Kornea aberasyonları korneal topografi-aberrometre (NİDEK Magellan Mapper) cihazı ile doğal olarak dilate pupilla ile ölçüldü. Sferik aberasyon, koma, trefoil, irregüler astigmatizma ve total yüksek sıralı aberrasyonların RMS değerleri kaydedildi. Tüm hastalara Balafilcon A (PureVision2 HD, B&L) lensi uygulanarak ölçümler tekrarlandı. Sonuçlar: Hastaların yaş aralığı 23-50 arasında değişmekteydi. İki gözde geçirilmiş adenoviral keratite bağlı subepiteliyal opasiteler, 11 gözde daha önce geçirilmiş enfeksiyon ya da travmaya bağlı korneal nefelyon, 2 gözde Salzmann nodüler dejenerasyonu mevcuttu. Kontakt lensler ile gözlüğe göre, Görme keskinliğinde ortalama 1 sıra, düşük kontrast görme keskinliğinde ortalama 5 harf artış gözlendi. Kontakt lensler ile sferik aberasyon, irreguler astigmatizma ve toplam yüksek sıralı aberasyonların ortalama RMS değerlerinde anlamlı azalma saptandı (p<0,05). Tar t›fl ma: Silikon hidrojel yumuşak kontakt lensler kornea opasitesi olan hastalarda kornea aberasyonlarını azaltarak görme kalitesini artırabilir. (Turk J Ophthalmol 2012; 42: 97-102) Anah tar Ke li me ler: Kornea opasiteleri, yüksek sıralı aberasyonlar, yumuşak kontakt lens Sum maryPur po se: Evaluation of the corneal high-order aberrations and visual quality changes after application of silicone hydrogel contact lenses in patients with corneal opacities due to various etiologies. Ma te ri al and Met hod: Fifteen eyes of 13 patients with corneal opacities were included in the study. During the ophthalmologic examination before and after contact lens application, visual acuity was measured with Snellen acuity chart and contrast sensitivity -with Bailey-Lowie Charts in letters. Aberrations were measured with corneal aberrometer (NIDEK Magellan Mapper) under a naturally dilated pupil. Spherical aberration, coma, trefoil, irregular astigmatism and total high-order root mean square (RMS) values were recorded. Measurements were repeated with balafilcon A lenses (PureVision 2 HD, B&L) on all patients. Re sults: Patient age varied between 23 and 50 years. Two eyes had subepithelial infiltrates due to adenoviral keratitis, 1 had nebulae due to previous infections or trauma, and 2 had Salzmann's nodular degeneration. We observed a mean increase of 1 line in visual acuity and 5 letters in contrast sensitivity with contact lenses versus glasses in the patients. Mean RMS values of spherical aberration, irregular astigmatism and total high-order aberrations decreased significantly with contact lenses. Dis cus si on: Silicone hydrogel soft contact lenses may improve visual quality by ...

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Contact Lens-Induced Regression of Lisch Epithelial Corneal Dystrophy

Abstract: Wearing CL for a longer duration causes a significant regression of corneal opacities in LECD. The etiology of this phenomenon is interpreted as a CL-induced thinning of corneal epithelium and reduction of epithelial layers.

Cited by 21 publications

References 13 publications

Development of strong and bioactive calcium phosphate cement as a light-cure organic–inorganic hybrid

Development of strong and bioactive calcium phosphate cement as a light-cure organic–inorganic hybrid

Treatment of Lisch Corneal Dystrophy With Photorefractive Keratectomy and Mitomycin C

Kornea Opasitelerinde Silikon Hidrojel Kontakt Lens Uygulamasının Yüksek Sıralı Kornea Aberasyonları ve Görme Kalitesi Üzerine Etkisi

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