Contact Lens Corneal Inflammatory Events in a University Population

Zimmerman, Aaron; Emch, Andrew J.; Geldis, Julia; Nixon, Gregory J.; Mitchell, G. Lynn

doi:10.1097/opx.0000000000000746

Cited by 14 publications

(9 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 68 Another study concurred, reporting PQ-1 plus Aldox was associated with more corneal infiltrative events compared to PHMB with daily wear CLs in a university population. 69 Comparing the overall efficacy of PHMB versus PQ-1 MPS, the studies above generally indicate that PHMB and PQ-1 plus Aldox (or in a few cases PQ-1 plus alexidine) are equally effective against bacteria and equally ineffective against fungi; however, PQ-1 plus Aldox is superior to PHMB MPS in efficacy against Acanthamoeba .…”

Section: Resultsmentioning

confidence: 99%

Common Ophthalmic Preservatives in Soft Contact Lens Care Products: Benefits, Complications, and a Comparison to Non-Preserved Solutions

Bradley¹,

Sicks²,

Pucker³

2021

OPTO

View full text Add to dashboard Cite

Purpose: Preservatives are essential for preventing contact lens (CL)-related microbial keratitis (MK). The purpose of this review is to summarize the current knowledge related to the use of common ophthalmic preservatives in CL care products with respect to both safety and efficacy. Methods: Manuscripts written in English were obtained by searching PubMed.gov with the term contact lens plus antimicrobial, benzalkonium chloride, biguanide, Aldox, polyquaternium, preservative, thimerosal, EDTA (ethylenediaminetetraacetic acid), chlorhexidine, or blister pack. Results: This review found that first-generation preservatives are no longer used in CL multipurpose solutions (MPS) due to their high levels of ocular toxicity. Modern, highmolecular-weight preservatives, including polyquaternium-1 (PQ-1) and biguanides (PHMB), are generally effective against bacteria, minimally effective against fungi, and not effective against Acanthamoeba. PQ-1 and PHMB are likely safe when used with CLs, but they may cause ocular adverse events, with roughly equal risk between the two preservatives. Some CL MPS contain both PQ-1 and PHMB, but no increased risk of adverse events has been reported when combining the two. Hydrogen-peroxide (H 2 O 2 ) solutions are effective against all common ocular microbes, including Acanthamoeba, and they have been proven safe with proper compliance. Povidone-iodine (P-I) solutions are not currently commercially available in North America, but they have been shown in other countries to be safe and effective. Conclusion:Patients should be monitored when using PQ-1 or PHMB-containing solutions since they have been associated with ocular adverse events. If events are detected, patients should be switched to an alternative solution. H 2 O 2 or P-I solutions are preferred for any patient who may expose their CLs to water because they are the only solution categories effective against Acanthamoeba.

show abstract

Section: Resultsmentioning

confidence: 99%

Common Ophthalmic Preservatives in Soft Contact Lens Care Products: Benefits, Complications, and a Comparison to Non-Preserved Solutions

Bradley¹,

Sicks²,

Pucker³

2021

OPTO

View full text Add to dashboard Cite

show abstract

“…240 Bioburden and specific lens care products or modalities may play a role in the development of CIEs, yet there appears to be no advantage to the use of antibiotics to reduce the incidence of CIEs during extended wear of silicone hydrogel lenses. [241][242][243][244][245] The exact relationship between CIEs and microbial keratitis remains unclear.…”

Section: Complicationsmentioning

confidence: 99%

Refractive Errors & Refractive Surgery Preferred Practice Pattern®

Chuck

Jacobs²,

Lee

et al. 2018

Ophthalmology

View full text Add to dashboard Cite

show abstract

“…Poor hand and lens case hygiene [67], overnight wear [67], smoking [67], showering in lenses [76] Water exposure [77], poor hand and lens hygiene [77,78], certain lens disinfecting solutions [77,79] Certain lens disinfecting solutions [80,81], non-scheduled lens replacement [80] Non-modifiable Male sex [68], young age [68] high SES [67] Caucasian race [77], low SES [77] Male sex [80], high income [80], Malay race [80] Pathognomic 4a and 4b; note that some studies did not analye all of the factors listed). Among the modifiable risk factors, overnight wear increases risk significantly [10,93,[97][98][99]. In these studies the increased risk ranged Incidence rate ratio, Rx: prescription.…”

Section: Risk Factors Modifiablementioning

confidence: 99%

BCLA CLEAR - Contact lens complications

Stapleton

Bakkar

Carnt

et al. 2021

Contact Lens and Anterior Eye

View full text Add to dashboard Cite

Contact lens-related complications are common, affecting around one third of wearers, although most are mild and easily managed. Contact lenses have well-defined anatomical and physiological effects on the ocular surface and can result in other consequences due to the presence of a biologically active material. A contact lens interacts with the tear film, ocular surface, skin, endogenous and environmental microorganisms, components of care solutions and other antigens which may result in disease specific to contact lens wear, such as metabolic or hypersensitivity disorders. Contact lens wear may also modify the epidemiology or pathophysiology of recognised conditions, such as papillary conjunctivitis or microbial keratitis. Wearers may also present with intercurrent disease, meaning concomitant or pre-existing conditions unrelated to contact lens wear, such as allergic eye disease or blepharitis, which may complicate the diagnosis and management of contact lens-related disease.Complications can be grouped into corneal infection (microbial keratitis), corneal inflammation (sterile keratitis), metabolic conditions (epithelial: microcysts, vacuoles, bullae, tight lens syndrome, epithelial oedema; stromal: superficial and deep neovascularisation, stromal oedema [striae/folds], endothelial: blebs, polymegethism/ pleomorphism), mechanical (corneal abrasion, corneal erosion, lens binding, warpage/refractive error changes; superior epithelial arcuate lesion, mucin balls, conjunctival epithelial flaps, ptosis, discomfort), toxic and allergic disorders (papillary conjunctivitis, solution-induced corneal staining, incomplete neutralisation of peroxide, Limbal Stem Cell Deficiency), tear resurfacing disorders/dry eye (contact lens-induced dry eye, Meibomian gland dysfunction, lid wiper epitheliopathy, lid parallel conjunctival folds, inferior closure stain, 3 and 9 o'clock stain, dellen, dimple veil) or contact lens discomfort. This report summarises the best available evidence for the classification, epidemiology, pathophysiology, management and prevention of contact lensrelated complications in addition to presenting strategies for optimising contact lens wear.

show abstract

Contact Lens Corneal Inflammatory Events in a University Population

Cited by 14 publications

References 45 publications

Common Ophthalmic Preservatives in Soft Contact Lens Care Products: Benefits, Complications, and a Comparison to Non-Preserved Solutions

Common Ophthalmic Preservatives in Soft Contact Lens Care Products: Benefits, Complications, and a Comparison to Non-Preserved Solutions

Refractive Errors & Refractive Surgery Preferred Practice Pattern®

BCLA CLEAR - Contact lens complications

Contact Info

Product

Resources

About