Contact immunotherapy of resistant warts

Naylor, Mark F.; Neldner, Kenneth H.; Yarbrough, Glenn K.; Rosio, Timothy J.; Iriondo, Manuel; Yeary, James

doi:10.1016/s0190-9622(88)70222-4

Cited by 65 publications

(59 citation statements)

References 16 publications

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“…For example, positive skin tests have been reported in patients with regressing warts or with a history of past warts challenged with purified papillomavirus capsid antigen [33] and in CIN patients on challenge with HPV-16 L1 peptides expressed as recombinant bacterial fusion protein [34]. Contact dermatitis induced by dinitrochlorobenzene at the site of recalcitrant verrucae provokes their rejection (351 and it has been suggested that any substance capable of reliably inducing a type IV hypersensitivity response can theoretically be used for the treatment of resistant warts [36]. The observations reported here have important implications for human infection with HPV and for vaccination strategy.…”

Section: Discussionmentioning

confidence: 99%

“Natural” presentation of human papillomavirus type‐16 E7 protein to immunocompetent mice results in antigen‐specific sensitization or sustained unresponsiveness

et al. 1994

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We have used a mouse model that utilizes the exclusively epithelial nature of human papillomavirus (HPV) infections to investigate the in vivo immune response to the E7 protein of human papillomavirus type-16. A keratinocyte cell line expressing E7 protein has been established and grafted onto syngeneic mice using a transplantation technique that permits the reformation of a differentiated epithelium on a granulation tissue bed. In this way viral antigens may be presented to the immune system in a way comparable to natural infection. A delayed-type hypersensitivity (DTH) response was studied post grafting by intradermal challenge with recombinant E7 protein. A significant response to E7 has been demonstrated in this way; however, priming with a low amount of HPV-16 E7 antigen induces immunological unresponsiveness, as measured by a loss of DTH reactivity to the protein, and persistence of keratinocytes expressing E7. Lymphocytes from mice exhibiting DTH reactivity have been shown to proliferate when stimulated with purified recombinant E7 protein in vitro, while immunoperoxidase staining of tissue from the sites of immunologically-induced inflammation has defined the cell infiltrate to be phenotypically characteristic of DTH. The observations reported here have important implications for vaccine strategy.

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Section: Discussionmentioning

confidence: 99%

“Natural” presentation of human papillomavirus type‐16 E7 protein to immunocompetent mice results in antigen‐specific sensitization or sustained unresponsiveness

et al. 1994

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“…The patients were sensitized with 0.1% DPCP (Sigma-Aldrich, Steinheim, Germany) on the skin of the buttock according to the method of Naylor et al 11 Fourteen days later, the patients returned to the hospital for investigation. The responses were evaluated using the erythema and blister index (EBI) and the pruritus index (PI).…”

Section: Methods Of Diphenylcyclopropenone Sensitizationmentioning

confidence: 99%

Comparison of cure rates and durations of treatment with diphenylcyclopropenone immunotherapy for warts in children/adolescents and adults

et al. 2014

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“…Both dinitrochlorobenzene (DNCB; Georgala et al, 1989) and diphencyprone (Naylor et al, 1988) have been described as effecting cure of genital warts. However, the recognition of mutagenicity induced by DNCB precludes its further use.…”

Section: Contact Hypersensitivitymentioning

confidence: 99%