Contact Dermatitis to Essential Oils

Buonomo, Michele; Warshaw, Erin M.

doi:10.1007/s13671-021-00337-2

Curr Derm Rep

2021

DOI: 10.1007/s13671-021-00337-2

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Contact Dermatitis to Essential Oils

Michele Buonomo

Erin M. Warshaw

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2024

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“…EOs and aromatic extracts have been a subject of concern due to reports of their skin sensitisation potential [59]. According to Buonomo and Warshaw [70], about 80 essential oils, including tea tree oil, thyme oil, neem oil, and eucalyptus oil, have been associated with contact allergy. Skin sensitisation is therefore an important dermal toxicological endpoint in the safety evaluation of natural cosmetic ingredients.…”

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Cosmetic Formulations from Natural Sources: Safety Considerations and Legislative Frameworks in the European Union

Manful,

Ahmed,

Barry-Ryan

2024

Cosmetics

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Consumer preferences, safety, and sustainability aspects of conventional cosmetic ingredients have contributed to an increase in the demand for natural cosmetic ingredients and products. Naturally derived active cosmetic agents and excipients may come into contact with various naturally occurring and synthetic contaminants throughout the supply chain, and substantiating their safety is essential. This review examines the safety and legislative requirements applicable to natural cosmetic ingredients in the European Union (EU). Cosmetic safety requirements include technical data based on the ingredient profile, presence of hazards and the risks associated with the intended conditions of use. The hazard analysis includes screening for microbial contaminants such as aerobic mesophilic bacteria, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans; chemical contaminants such as lead, cadmium, arsenic, and mercury; and naturally occurring toxins, such as allergens. The toxicological assessment considers both local effects (such as skin sensitisation, eye/skin irritation, and photo-induced effects) and systemic effects (including acute dermal toxicity, sub-acute and sub-chronic toxicity, mutagenicity and carcinogenicity, reproductive toxicity, and toxicokinetics). The EU legislative requirements prohibit the use of animal-based tests for the toxicological evaluation of cosmetic ingredients, paving the way for alternatives termed as New Approach Methodologies (NAMs). The validation of NAMs is critical for their wider usage, and despite advancements, few have been validated, particularly for systemic toxicity testing. The use of NAMs in evaluating the safety of complex natural cosmetic ingredients is further examined.

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confidence: 99%

Cosmetic Formulations from Natural Sources: Safety Considerations and Legislative Frameworks in the European Union

Manful,

Ahmed,

Barry-Ryan

2024

Cosmetics

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Harmonizing Nature and Technology: Lipidic Nano-phytotherapeutics in the Management of Atopic Dermatitis

Kant,

Kaur,

Mishra

et al. 2024

Rev. Bras. Farmacogn.

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Liabilities of essential oils as insect repellents

Farina,

Conti

2024

Current Opinion in Environmental Science & Health

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Contact Dermatitis to Essential Oils

Cited by 3 publications

References 0 publications

Cosmetic Formulations from Natural Sources: Safety Considerations and Legislative Frameworks in the European Union

Cosmetic Formulations from Natural Sources: Safety Considerations and Legislative Frameworks in the European Union

Harmonizing Nature and Technology: Lipidic Nano-phytotherapeutics in the Management of Atopic Dermatitis

Liabilities of essential oils as insect repellents

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