Contact dermatitis in reaction to 2% topical minoxidil solution

Wilson, Caroline; Walkden, Valerie; Powell, Sheila; Shaw, S.; Wilkinson, J. D.; Dawber, R.P.R.

doi:10.1016/s0190-9622(08)80171-5

Cited by 27 publications

(17 citation statements)

References 4 publications

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“…There are many reports of contact dermatitis. [77][78][79][80][81][82][83] These were historically thought to be caused by minoxidil itself, but patch testing recently identified propylene glycol (present in minoxidil solution) as the causative agent in 9 of 11 patients, while only 4 of 11 reacted to minoxidil. 84 The substitution of butylene glycol for propylene glycol was well tolerated.…”

Section: Side Effectsmentioning

confidence: 99%

Medical treatments for male and female pattern hair loss

Rogers¹,

Avram²

2008

Journal of the American Academy of Dermatology

237

166

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Section: Side Effectsmentioning

confidence: 99%

Medical treatments for male and female pattern hair loss

Rogers¹,

Avram²

2008

Journal of the American Academy of Dermatology

237

166

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“…However, there are significant adverse dermatological effects associated with minoxidil, including pruritis, dryness, scaling, local irritation, and dermatitis. [5][6][7][8] Oral finasteride, a competitive inhibitor of type-2 5-α-reductase, is known to increase hair growth in patients with male pattern baldness (androgenetic alopecia). It was reported that 48% of hair regrowth was observed in finasteride recipients in one year.…”

mentioning

confidence: 99%

<i>In Vivo</i> Hair Growth-Promoting Effect of Rice Bran Extract Prepared by Supercritical Carbon Dioxide Fluid

Choi

Jeon²,

Moon³

et al. 2014

Biological & Pharmaceutical Bulletin

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The potential hair growth-promoting activity of rice bran supercritical CO 2 extract (RB-SCE) and major components of RB-SCE, linoleic acid, policosanol, γ-oryzanol, and γ-tocotrienol, were evaluated with the histological morphology and mRNA expression levels of cell growth factors using real-time reverse transcriptase-polymerase chain reaction (PCR) in C57BL/6 mice. RB-SCE showed hair growth-promoting potential to a similar extent as 3% minoxidil, showing that the hair follicles were induced to be in the anagen stage. The numbers of the hair follicles were significantly increased. In addition, mRNA expression levels of vascular endothelial growth factor (VEGF), insulin-like growth factor-1 (IGF-1), and keratinocyte growth factor (KGF) were also significantly increased and that of transforming growth factor-β (TGF-β) decreased in RB-SCE-treated groups. Among the major components of RB-SCE, linoleic acid and γ-oryzanol induced the formation of hair follicles according to examination of histological morphology and mRNA expression levels of cell growth factors. In conclusion, our results demonstrate that RB-SCE, particularly linoleic acid and γ-oryzanol, promotes hair growth and suggests RB-SCE can be applied as hair loss treatment. Key words rice bran supercritical CO 2 extract; hair growth-promoting activity; in vivoAlthough hair loss is not a mortal disorder, it has a great impact on a person's self-respect, mental health, and overall quality of life. Approximately 50-60 hairs are normally lost per day, which does not have a noticeable effect on appearance; however, excess loss (>100) results in baldness. Androgenetic alopecia is the most common type of hair loss, affecting millions of both men and women.1) There are many causes of hair loss in men and women, including diseases, nutritional deficiency, aging, hormone imbalance, and stress. Androgenetic alopecia may occur as early as the teenage years, but typically begin in the later decades of life. 2,3) Hair loss affects at least half of all men by the age of 50 and up to 70% of 70-year-old men. 4)

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“…[1][2][3]21) Although topical minoxidil and oral finasteride are available for the treatment of alopecia, these medicines have sometimes been reported to have adverse effects. [7][8][9][10] In our previous study, RB-SCE showed hair growth-promoting potential similar to that of 3% minoxidil, as evidenced by findings of hair follicles induced in the anagen stage, and a significant increase in the number of hair follicles in C57BL/6 mice.…”

Section: Discussionmentioning

confidence: 94%

“…6) Generally, minoxidil is well tolerated for long-term daily use. Side effects of minoxidil are uncommon, but contact dermatitis, 7) skin irritation, 8,9) dizziness, and tachycardia 9) have been reported. Finasteride is also generally well tolerated, with few adverse effects reported over 5 years.…”

mentioning

confidence: 99%

Safety and Efficacy of Rice Bran Supercritical CO<sub>2</sub> Extract for Hair Growth in Androgenic Alopecia: A 16-Week Double-Blind Randomized Controlled Trial

Choi

Park

Moon³

et al. 2015

Biological & Pharmaceutical Bulletin

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We conducted a 16-week double-blind randomized controlled single-center trial to evaluate the safety and efficacy of dermal rice bran supercritical CO 2 extract (RB-SCE) in the treatment of androgenic alopecia. Fifty alopecia patients were randomly assigned to the experimental and placebo groups. The experimental group received a dermal application of 0.5% RB-SCE (8 mL/d) to the head skin for 16 weeks while the control group received a dermal application of placebo. Changes in hair count, diameter, and density were evaluated with a Folliscope ® . Patient satisfaction was evaluated via questionnaire and clinical photographs were rated by dermatologists. The results showed that RB-SCE significantly increased hair density and hair diameter in male subjects. Patient satisfaction and the evaluation of photographs by dermatologists also confirmed the effectiveness of RB-SCE in the treatment of alopecia. No adverse reactions related to RB-SCE were reported. Therefore, RB-SCE shows promise for use in functional cosmetics and pharmaceuticals.

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Contact dermatitis in reaction to 2% topical minoxidil solution

Cited by 27 publications

References 4 publications

Medical treatments for male and female pattern hair loss

Medical treatments for male and female pattern hair loss

<i>In Vivo</i> Hair Growth-Promoting Effect of Rice Bran Extract Prepared by Supercritical Carbon Dioxide Fluid

Safety and Efficacy of Rice Bran Supercritical CO<sub>2</sub> Extract for Hair Growth in Androgenic Alopecia: A 16-Week Double-Blind Randomized Controlled Trial

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