Medical treatments for male and female pattern hair loss

Androgenetic Alopecia: A Chronic or Pubertal Onset Disease Retarded by Blood Donation

“…As mentioned earlier, platelets are absolutely essential for hair growth and platelet rich plasma preparations are potentially useful in prevention of hair loss [3][4][5][6][7][8][9][10][11]. Despite the facts that the platelets count in AGA patients was at normal range with 238.16 ± 59.70 × 10 3 platelet/µL, but it was lower than that in control group with 267.79 ± 68.23 × 10 3 platelet/µL (P value < 0.01).…”

“…Androgenetic alopecia (AGA), male pattern baldness, common baldness or androgen-dependent alopecia, is the most common form of hair loss in males and females which is associated with psychological discomfort and depression [1,2].The incidence of AGA is estimated to be 50 percent in both sexes above 50 years of ages [3]. This kind of baldness is described as progressive loss in pigmented terminal hair on the scalp concurrent with predominant onset in puberty upon increase in sexual hormones [4][5][6].…”

Androgenic alopecia and dutasteride in hair mesotherapy: A short review

“…In addition, there is only two FDA-approved therapies: finasteride, a type II 5α-reductase inhibitor that present well documented sexual adverse effects and minoxidil, a vasodilator that may present unwanted hair grow [42].…”

“…Recently, Chung and coworkers showed that dutasteride for more than 6 years was safe and increased terminal, vellus and total hair count in male AGA patients [47]. On the other hand, adverse effects to those presented by finasteride (alterations on erectile, ejaculatory functions and fertility) and its long half life (4 weeks) [42] are the main factors that contribute to the reluctance on the use of dutasteride in AGA. Thus, the local administration of dutasteride by mesotherapy and a consequent reduction of systemic side effects is a relevant tool on AGA treatment [48].…”

Topical Nanoemulgel: A Novel Pathway for Investigating Alopecia

“…The oral use of minoxidil results in several side effects like weight gain, severe water retention, etc. In order to avoid these side effects, the topical formulations of minoxidil are going to be the best treatment for alopecia by showing its better efficacy and prolong drug action [6].…”