Contact Dermatitis From Stearyl Alcohol and Propylene Glycol in Fluocinonide Cream

Shore, Ronald N.; Shelley, Walter B.

doi:10.1001/archderm.1974.01630030055015

Cited by 36 publications

(6 citation statements)

References 2 publications

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“…Our ROAT results suggest that untoward reactions to higher fatty alcohols do occur, and they can be demonstrated in most of the patients with positive patch test reactions. The real cause of contact hypersensitivity could be impurities in commercial batches sold as cetyl and stearyl alcohols and mixtures of these (12,17). In 6 of our 7 patients with an allergic patch test reaction to Lanette N or Lanette 16, chemically pure cetyl alcohol did not produce a positive patch test reaction.…”

Section: Discussionmentioning

confidence: 63%

“…The occurrence of cetyl and stearyl alcohol allergy in eczema patients in Finland is 0.7% (Table 2), which means that the risk of contact allergy is very low. There are several reports from Europe in which the number of positive patch test reactions to cetyl and, cetylstearyl alcohols has varied between 0.2 and 44% ( Table 2), but such reactions are only occasionally found in other parts of the world (17,18).…”

Section: Discussionmentioning

confidence: 99%

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The repeated open application test (ROAT)

1986

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Repeated open application tests (ROATs) were performed with common ingredients of vehicles in 86 patients with contact dermatitis. The substances were applied twice daily for 7 days to the flexor aspect of the forearm near the cubital fossa, unless dermatitis appeared earlier. Of the patients with a questionable (?+) patch test result, 44% were positive in ROATs. The corresponding figure was 80% in the patients with a positive (+ or ++) response in the patch test, when the results of ROAT with propylene glycol were excluded. Only 5 of 14 patients reacting to 30% or to 10% propylene glycol but not to 1% in water in patch testing, showed a positive result to a cream containing 5% propylene glycol in ROAT. All 5 patients with a positive patch test reaction to 1% propylene glycol reacted to 5% propylene glycol in ROAT. The results suggest that ROATs should be performed more often, especially in patients in whom little known or new allergens are suspected as being the cause of allergic contact dermatitis.

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Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

The repeated open application test (ROAT)

1986

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“…Contact allergy to cetyl and stearyl alcohols is almost always due to impurities present even in pharmaceutical and cosmetic grades (10,11). Our results show that sensitization to oleyl alcohol is 5% pet.…”

Section: Discussionmentioning

confidence: 99%

Contact dermatitis from fatty alcohols

et al. 1996

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The aim of this study was to investigate the frequency of sensitization to fatty alcohols in a group of patients with suspected cosmetic or medicament contact dermatitis. From May 1992 to September 1995, we patch tested a series of 5 fatty alcohols on 146 patients. These included 108 females and 38 males aged from 13 to 72 years (mean age 42.5). These patients, who had previously been tested with the GIRDCA standard series, were selected because their clinical lesions or histories indicated topical preparations as the possible source of their contact dermatitis. High-grade fatty alcohols (> 99% pure) were used for testing. 34 patients (23.2%), 25 female and 9 male aged from 14 to 72 years, showed a positive patch test to fatty alcohols, 33 of them to oleyl alcohol. A total of 39 reactions were detected with 5 patients showing more than 1 positive reaction. Our results show that sensitization to oleyl alcohol is not rare in patients with contact dermatitis due to cosmetics or topical medicaments.

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“…This belief is based on t h e paucity of reports on emulsifier allergy in recent years. T h e majority of such reports have dealt with cetyl and stearyl alcohols (2)(3)(4)(5)(6)(7)(8)(9). but contact allergy t o various other emulsifiers has also been found t o be of clinical importance (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20).…”

Section: Introductionmentioning

confidence: 99%

Skin contact allergy to emulsifiers

Hannuksela

1988

Intern J of Cosmetic Sci

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Synopsis Contact allergy to cetyl and stearyl alcohols has been reported for many years. About one per cent of eczema patients are allergic to either alcohol or a mixture of the two. In the present study, 11 of 1374 patients reacted to 20% cetylstearyl alcohol in patch tests. Results of a previous study, suggested that some impurities in commercial cetyl and stearyl alcohols might be responsiblefor the contact allergies. Sorbitan esters are also contact allergens in dermatological preparations. Sorbitan sesquioleate (20% in petrolatum) was patch-tested in 4469 eczema patients in the present study, with a positive result in 25 (0.56%) of them. Widespread dermatitis from moisturizing creams was seen in two patients, one of whom was treated with peroral corticosteroids and the other with a potent corticosteroid cream. Several other emulsifiers have also occasionally been found to cause contact allergy. Popular emulsifiers are thus potential allergens, especially in preparations commonly used as moisturizersfor dry or slightly eczematous skin. Les allergies cutanees aux emulsifiants.

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Contact Dermatitis From Stearyl Alcohol and Propylene Glycol in Fluocinonide Cream

Cited by 36 publications

References 2 publications

The repeated open application test (ROAT)

The repeated open application test (ROAT)

Contact dermatitis from fatty alcohols

Skin contact allergy to emulsifiers

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