Contact Dermatitis Due to Nickel and Chromate

Epstein, Stephan

doi:10.1001/archderm.1956.01550030038003

Cited by 66 publications

(10 citation statements)

References 21 publications

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“…From our investigation, it is not possible to conclude which are the primary and secondary events, but most facts earlier presented indicate that nickel sensitivity followed by irritant dermatitis of the hands appears first, and that cobalt sensitivity is a secondary phenomenon (15)(16)(17). It is possible that a pre-existant nickel allergy increases the risk of developing cobalt allergy, not only because of the high frequency of hand eczema among nickel sensitive individuals but also due to unknown immunological factors (18,19). The cobalt allergy then seems to aggravate the hand eczema.…”

Section: Discussionmentioning

confidence: 61%

Relationship between nickel and cobalt sensitization in hard metal workers

1983

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853 hard metal workers were examined and patch tested with 20 substances from their environment, including nickel and cobalt. Nickel sensitivity was found in 2 men and 38 women. 88% of the nickel-sensitive individuals had developed a jewelry dermatitis prior to employment in the hard metal industry or before the appearance of hand eczema. 29% of the hard metal workers gave a history of slight irritant dermatitis. In the nickel sensitized group, 40% had had severe hand eczema which generally appeared 6-12 months after starting employment. In 25% of the cases, nickel sensitive individuals developed cobalt allergy, compared with 5% in the total population investigated. Most facts indicate that nickel sensitivity and irritant hand eczema precede cobalt sensitization. Hard metal workers with simultaneous nickel and cobalt sensitivity had a more severe hand eczema than those with isolated cobalt or nickel sensitivity or only irritant dermatitis. 64% of the female population had pierced ear lobes. Among the nickel allergic women, 95% had pierced ear lobes. The use of earrings containing nickel after piercing is strongly suspected of being the major cause of nickel sensitivity. Piercing at an early age seems to increase the risk of incurring nickel sensitivity.

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Section: Discussionmentioning

confidence: 61%

Relationship between nickel and cobalt sensitization in hard metal workers

1983

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“…The relationship between atopy and nickel allergy is debated in several papers. Epstein (1956), Dobson (1963), Watt & Baumann (1968) found a marked positive correlation between nickel allergy and atopy whereas Calnan (1956), Wilson (1956), Marcussen (1957) and Caron (1964) found no such connection. Wahlberg & Skog (1971) found a high frequency of family atopy in relation to nickel sensitive patients.…”

Section: Discussionmentioning

confidence: 98%

Prognosis in nickel allergy and hand eczema

Christensen¹

1982

Contact Dermatitis

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63 female patients with nickel allergy and hand eczema were reinvestigated 6 years after the primary investigation. 30% of the patients were healed. Patients with the pompholyx-type eczema had the worst prognosis. The start of hand eczema was not correlated to any particular occupation. There was a strong correlation between a history of metal sensitivity and a positive patch test reaction. High frequencies of personal and family atopy were found, and atopy made the prognosis worse. Determination of serum IgE was not found to be of any use in predicting the prognosis in patients with nickel allergy and hand eczema.

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“…This arouses the interesting speculation as to whether the molecular configuration of prednisolone has some special affinity for a metallic protein complex such as might be formed in chromate eczema. 5. In all four cases, after a period of complete nonexposure to chromâtes, the very marked repressive action of both hydrocortisone and prednisolone in chromate der¬ matitis was strikingly evident.…”

Section: Resultsmentioning

confidence: 82%

Chromate Dermatitis

Bernhardt¹

1957

AMA Arch Derm

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Contact Dermatitis Due to Nickel and Chromate

Cited by 66 publications

References 21 publications

Relationship between nickel and cobalt sensitization in hard metal workers

Relationship between nickel and cobalt sensitization in hard metal workers

Prognosis in nickel allergy and hand eczema

Chromate Dermatitis

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