Contact Dermatitis Due to Clindamycin

Allergic contact dermatitis caused by clindamycin mimicking ‘retinoid flare’

“…We report a case of ACD caused by topical clindamycin in a patient with acne vulgaris. A similar case was described for the first time in 1978 , and since then such cases have been occasionally reported in patients with acne and other conditions . Despite the apparently low sensitizing potential of clindamycin, we suppose that the prolonged application of topical acne products containing this substance on irritated skin (retinoid dermatitis) may increase the risk of sensitization.…”

“…Topical clindamycin is active against most Gram‐positive and anaerobic bacteria, and is widely used for the treatment of acne vulgaris . Clindamycin is regarded as a weak contact allergen; few cases of topical clindamycin sensitization have been described in the literature . We describe a case of allergic contact dermatitis (ACD) caused by clindamycin in a patient with papulo‐pustular acne.…”

Allergic contact dermatitis to topical antibiotics: Epidemiology, responsible allergens, and management

“…128 The first case of clindamycin contact allergy was reported in 1978. 129 Clindamycin is a weak allergen accounting for only five case reports in the literature. 130 An illustrative case is that of a 21-year-old male who was treated for acne vulgaris with clindamycin lotion 1%.…”

Topical clindamycin in the management of acne vulgaris

“…There has also been one case report of diarrhea, confirmed by dechallenge and rechallenge, which was not mediated by C. difficile [98] . Four cases of patch-test-confirmed contact dermatitis have also been linked to topical clindamycin therapy [99][100][101][102] . In one of these cases, oral clindamycin therapy may have played a role as well [102] .…”