Contact allergy to Tinosorb® M: recommendations for diagnostic improvement

Abstract

A 56-year-old woman developed an itchy, red and burning eruption on her face and neck 1-2 days after the application of a sunscreen (sun cream SPF 30). Treatment with a corticosteroid cream resulted in rapid improvement. Later, the patient experienced a similar eruption after the use of another sunscreen of a different University Medical Centre, with the European baseline series, and patch and photopatch tested with a photopatch test series [containing a number of ultraviolet (UV) filters] and the two incriminated cosmetic products. At D2 and D3, positive reactions were observed to both sunscreen creams (tested undiluted), with equal strengths (+) on the irradiated and non-irradiated sites. The ingredients were subsequently requested from the manufacturers. After the constituents of one of them had been received (n = 32), the patient was patch tested with these (delivery of the ingredients of the other product was delayed) and retested with the sunscreen cream itself. Contact allergy to the sunscreen cream was confirmed (D2 ?+; D3 +), and there was also a positive reaction (D2 +, D3 +) to a mixture of methylene bis-benzotriazolyl tetramethylbutylphenol (nano), decyl glucoside, propylene glycol and xanthan gum 58% in water (test concentration, 14% in water; solid ingredients, 14% of 58% = 8.1%). Xanthan gum was tested separately and gave a negative result. This mixture, which is the UV

Photoallergy

“…Tinosorb M was found to be the most common cause of allergic contact dermatitis in EMCPPTS. Available data suggest that decyl glucoside is more likely to be the culprit, rather than the UV filter in this product (68,96).…”

“…Tinosorb M, an efficient sunscreen using microfine particle technology, provides UV absorption by a photostable organic molecule as well as light scattering and light reflection by its microfine structure (96). To enhance the solubility of the UV filter methylene bis-benzotriazolyl tetramethylbutylphenol in cosmetic products, emulsifiers and surfactants are added to the compound including the surfactant decyl glucoside.…”

Quantified Self in de huisartsenpraktijk

“…Het is voor consumenten de afgelopen jaren steeds makkelijker geworden om hun eigen gezondheidsdata te genereren [1]. Verschillende soorten activity trackers en gezondheidsapplicaties voor de smartphone maken het relatief eenvoudig om persoonlijke gegevens te verzamelen over beweging, voeding, slaap, hartslag, menstruatiecyclus, etc.…”

Allergic contact dermatitis to decyl glucoside: Still an important allergen in Tinosorb M

“…Since its first description in 2006, the organic UV filter Tinosorb M is in the focus due to sensitization by its surfactant decyl glucoside . Tinosorb M is a widely used UV filter complex that contains the active component bisoctrizole (CAS no.…”

“…Tinosorb M is a widely used UV filter complex that contains the active component bisoctrizole (CAS no. 103597‐45‐1; or methylene bis‐benzotriazolyl tetramethylbutylphenol), propylene glycol, xanthan gum, water, and the surfactant decyl glucoside, an alkyl glucoside …”