Contact allergy to reactive diluents and related aliphatic epoxy resins

Abstract

Allergic reactions to reactive diluents and related aliphatic epoxy resins usually occurred together with reactions to DGEBA-R. BDDGE was the clinically most significant compound, and was the sole cause of occupational allergic contact dermatitis in 3 patients.

Sensitization to reactive diluents and hardeners in epoxy resin systems. IVDK data 2002–2011. Part II: concomitant reactions

“…Remarkably, the percentages of concomitant reactions to PGE and CGE, but not to PTBPGE and PGE, are quite similar to those observed by Aalto‐Korte et al. . In all, the percentages of positive reactions to these reactive diluents were lower in the FIOH data, probably because of a more deliberate indication for patch testing.…”

“…However, Aalto‐Korte et al. stated that exposure to 1,4‐BDDGE was more common in their study population than exposure to 1,6‐HDDGE, which may be the reason why 1,4‐BDDGE was the clinically most significant reactive diluent in their test series .…”

“…reported 3 patients reacting to BGE, but no corresponding exposure could be found. In 2 of them, 1,4‐BDDGE was also tested, and both reacted positively . In addition, it is remarkable that BGE, which had a very high EC3 value in the local lymph node assay , indicating low sensitizing potency, elicited positive patch test reactions in almost 11% of the patients tested .…”

“…At the FIOH, 1,6‐HDDGE had been tested in a limited number of patients only. Therefore, concomitant reactivity to 1,4‐BDDGE could not be analysed on a large scale . However, Aalto‐Korte et al.…”

“…Beside the basic resins, hardeners and reactive diluents are important sensitizers in epoxy resin systems (ERSs) (–). This is the second part of a data analysis from the Information Network of Departments of Dermatology (IVDK), 2002–2011, on sensitization to epoxy resin hardeners and reactive diluents, focusing on concomitant reactivity.…”