Sensitization to reactive diluents and hardeners in epoxy resin systems. <scp>IVDK</scp> data 2002–2011. Part <scp>II</scp>: concomitant reactions

Geier, Johannes; Lessmann, Holger; Hillen, Uwe; Skudlik, Christoph; Jappe, Uta

doi:10.1111/cod.12490

Cited by 17 publications

(8 citation statements)

References 20 publications

(32 reference statements)

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“…In construction workers and painters, these reactions were associated with positive reactions to manifold hardeners and reactive diluents used in epoxy resin systems (Table S1). Concomitant reactions between aromatic glycidyl ethers might be explained by immunological cross‐reactivity 44 …”

Section: Discussionmentioning

confidence: 99%

“…Concomitant reactions between aromatic glycidyl ethers might be explained by immunological cross-reactivity. 44 Positive PT reactions to colophonium were documented in 4.2% of the patients (Table 3) and considered occupationally relevant in all handicraft professions with the exception of construction workers, and in an office clerk (Table 4). Abietic acid is the major allergen in colophonium and distilled tall oil, which is widely used in wbMWFs.…”

Section: Glues and (Epoxy) Resinsmentioning

confidence: 99%

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Relevance of contact sensitizations in occupational dermatitis patients with special focus on patch testing of workplace materials

et al. 2020

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Background: Studies on patch testing with workplace materials and evaluation of current occupational relevance of positive patch test reactions are scarce in patients with occupational dermatitis (OD). Objectives: To identify frequent sensitizations with occupational relevance and to determine the value of patch testing with workplace materials in OD patients. Patients and Methods: Results and clinical data of 654 patients with suspected OD patch tested between 2013 and 2017 were analysed. Results: Occupational allergic contact dermatitis was diagnosed in 113 (17.3%) patients. Mechanics had the widest range of occupational sensitizations. Sensitization to epoxy resin was rated occupationally relevant in almost all handicraft trades. Among positive patch test reactions to workplace products, those to water-based metal working fluids and leave-on cosmetic products were most frequent. Despite frequent testing, protective gloves only rarely elicited positive reactions. Preservatives and rubber compounds were most frequently identified as currently occupationally relevant. Conclusions: Rubber allergy is occupationally relevant especially in healthcare workers and cleaners. Generally, preservatives including formaldehyde releasers are important allergens in OD patients. Leave-on cosmetic products must not be forgotten as allergen sources. Patch testing both workplace materials and standardized test

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Section: Discussionmentioning

confidence: 99%

Section: Glues and (Epoxy) Resinsmentioning

confidence: 99%

Relevance of contact sensitizations in occupational dermatitis patients with special focus on patch testing of workplace materials

et al. 2020

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“…In an IVDK analysis of all patch test reactions to epoxy resin and other components of epoxy resin systems between 2002 and 2011, 40% of patients sensitized to epoxy resin had a concomitant patch test reaction to glycidyl ethers 26 . This is roughly the same dimension as in the current study group (difference not significant).…”

Section: Discussionmentioning

confidence: 45%

Occupational contact dermatitis in painters and varnishers: Data from the Information Network of Departments of Dermatology (IVDK), 2000 to 2019

et al. 2021

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Introduction Painters and varnishers (“painters”) are exposed to various contact allergens and skin irritants, and therefore, are at risk for developing occupational dermatitis (OD). Objective To describe the spectrum of occupational sensitizations in painters and revise the corresponding current patch test recommendations. Patients and Methods Retrospective analysis of Information Network of Departments of Dermatology (IVDK) data from 2000 to 2019 with focus on male painters with OD, ages 20‐59 years (n = 557) in comparison to age‐matched male painters without OD (n = 422) and male OD patients who have had never worked as painters (n = 13 862). Results Male painters with OD have a significantly higher rate of allergic contact dermatitis and face dermatitis than male patients with OD who work in other professions. Positive patch tests to epoxy resin, methylisothiazolinone (MI), and methylchloroisothiazolinone (MCI)/MI were significantly more frequent in painters with OD than in the other groups. Epoxy resin sensitization was significantly associated with face dermatitis. Conclusions Epoxy resin, MI, and MCI/MI represent the most important occupational sensitizers in painters. In addition to baseline, resins and glues, and industrial biocides series, the patients' own workplace materials should be tested in painters with suspected OD.

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“…A retrospective analysis of data from the Information Network of Departments of Dermatology (IVDK), 2002–2011, demonstrated that almost half of the patients sensitized to epoxy resin were additionally sensitized to reactive diluents or hardeners. Among the reactive diluents, 1,6-hexanediol diglycidyl ether was the most frequent contact allergen, followed by 1,4-butanediol diglycidyl ether (both often cross-react [ 125 ]), phenyl glycidyl ether, and p-tert -butylphenyl glycidyl ether. Among the hardeners, m-xylylene diamine (MXDA) and isophorone diamine (IPDA) were the most frequent contact allergens.…”

Section: Resultsmentioning

confidence: 99%

Contact Allergy: A Review of Current Problems from a Clinical Perspective

Uter

Werfel

White

et al. 2018

IJERPH

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Contact allergy is common, affecting 27% of the general population in Europe. Original publications, including case reports, published since 2016 (inclusive) were identified with the aim of collating a full review of current problems in the field. To this end, a literature search employing methods of systematic reviewing was performed in the Medline® and Web of Science™ databases on 28 January 2018, using the search terms (“contact sensitization” or “contact allergy”). Of 446 non-duplicate publications identified by above search, 147 were excluded based on scrutiny of title, abstract and key words. Of the remaining 299 examined in full text, 291 were deemed appropriate for inclusion, and main findings were summarised in topic sections. In conclusion, diverse sources of exposures to chemicals of widely-differing types and structures, continue to induce sensitisation in man and may result in allergic contact dermatitis. Many of the chemicals are “evergreen” but others are “newcomers”. Vigilance and proper investigation (patch testing) are required to detect and inform of the presence of these haptens to which our populations remain exposed.

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Sensitization to reactive diluents and hardeners in epoxy resin systems. IVDK data 2002–2011. Part II: concomitant reactions

Abstract: More detailed knowledge of cross-reactivity among ERS components facilitates the interpretation of patch test results and will allow safer ERSs to be composed in the future.

Cited by 17 publications

References 20 publications

Relevance of contact sensitizations in occupational dermatitis patients with special focus on patch testing of workplace materials

Relevance of contact sensitizations in occupational dermatitis patients with special focus on patch testing of workplace materials

Occupational contact dermatitis in painters and varnishers: Data from the Information Network of Departments of Dermatology (IVDK), 2000 to 2019

Contact Allergy: A Review of Current Problems from a Clinical Perspective

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