Contact allergy to acrylates in Apple AirPods Pro® headphones: A case series

Shaver, Rob L; Buonomo, Michele; Scherman, Joseph; Neeley, Anne B

doi:10.1111/ijd.15954

Cited by 6 publications

(4 citation statements)

References 5 publications

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“…Despite the increasing fashion of wireless headphones, our case is the first report of ACD to wireless over‐ear headphones, since the only four previously reported cases were caused by in‐ear headphones 2–5 . Moreover, in these few cases, isothiazolinones were never reported as culprit allergens.…”

Section: Discussionmentioning

confidence: 73%

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Wireless over‐ear headphones: A new source of allergic contact dermatitis to isothiazolinones

Caroppo,

Stingeni,

Goracci

et al. 2024

Contact Dermatitis

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Psoralen-containing plants have a significant role in the treatment of vitiligo in both traditional and modern medicine systems.There are many modern medicines that contain psoralens isolated from plants (rather than artificially synthesised psoralens), which are administered in regulated protocols for photochemotherapy using artificial UV-A light (PUVA) or sunlight as the source of UV-A (PUVAsol). Even therapies developed from traditional systems also mention titration of dose and duration of sun exposure, and gradual increase, similar to PUVAsol therapy in modern medicine. But such traditional preparations are often used unsupervised by the patients. They often use excessive dose of the active component or excessive sun exposure without subsequent photoprotection, often intentionally in hopes of getting faster pigmentation, or inadvertently due to unregulated preparations leading to severe adverse effects. The topical formulations can lead to very high concentration of the drug in the skin, which can be more injurious and have lower thresholds of sun exposure to produce phototoxic reactions. 4 Frequently, after resolution of acute dermatitis, there might be development of slight hyperpigmentation over the exposed normal skin and some repigmentation over the vitiligo patches. It is suggested that the perifollicular melanocytes undergo significant damage during the acute dermatitis episodes, limiting the response to future phototherapy interventions. [4][5][6] Mild hypopigmented scarring, as seen in our patient, can also occur, which also limits future response.In conclusion, severe phytophototoxic reactions to psoralen-containing plants taken for treatment for vitiligo can present as thermal burns. When introduced to such therapies, patients must be sensitised about the potential adverse effects of overdose or overexposure and the need for complete photoprotection apart from the strictly titrated duration of sun exposure similar to PUVAsol therapy.

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Section: Discussionmentioning

confidence: 73%

“…The advances in wireless audio technology increased the Bluetooth headphone use to enhance mobility, to redefine connection with cellphones and to improve audio quality. Cases of ACD to wireless headphones were rarely reported, and they all were caused by in‐ear headphones due to gold 2 and acrylates 3–5 …”

mentioning

confidence: 99%

Wireless over‐ear headphones: A new source of allergic contact dermatitis to isothiazolinones

Caroppo,

Stingeni,

Goracci

et al. 2024

Contact Dermatitis

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“…With the widespread adoption of wireless in‐ear headphones, a growing number of reported cases of contact dermatitis are associated with their use. Previous reports have mainly concentrated on the auricle, where the external auditory canal exhibits skin‐like manifestations and can also experience contact dermatitis 1,2 . Here, we present a case of localized contact dermatitis affecting both the concha and the external auditory canal, attributed to using in‐ear headphones.…”

mentioning

confidence: 88%

Allergic contact dermatitis to in‐ear headphones occurring in the external ear

Hua,

Jin,

Yao

et al. 2024

Contact Dermatitis

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All results were negative on D2 and D7. Our patient is currently on medical leave and remains asymptomatic. DISCUSSIONNo reports of airborne allergic contact dermatitis from PVA-based coating formulations (Opadry ® ) or yellow pigment in an occupational context were found in the literature.In our case, PT with excipients provided from the pharmaceutical laboratory was particularly important due to the lack of standardised commercial tests. The initial tests carried out with the entire finished formulation of the drugs were negative, probably because the concentration of excipients present in these was not high enough to trigger a PT reaction. Moreover, our case emphasizes the importance and relevance of identifying the exact culprit agent(s) in order to recommend and install appropriate avoidance measures. As excipients are rarely suspected, and usually considered hidden allergens, greater awareness concerning their sensitising potential may be needed. 4 In conclusion, we report a first case of occupational airborne allergic contact dermatitis from a PVA-based coating formulation (Opadry ® ). The widespread utilisation of polymers in diverse applications highlights their potential as (occupational) contact sensitizers.

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“…39 Awareness of the common use of acrylates is important to identify the cause of reactions from products that would otherwise seem nonallergenic. A case of occupational ACD to isobornyl acrylate in UV-cured phone screen protectors has been reported 40 ; several cases of ACD to acrylates in headphones 41,42 as well as one related to a wearable fitness device also have been reported. 43 Given all these possible sources of exposure, ACD to acrylates should be on your radar.…”

Section: Modern Sources Of Acrylate Exposurementioning

confidence: 99%

Tackling Acrylate Allergy: The Sticky Truth

Rodriguez

2023

Cutis

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Acrylates are synthetic thermoplastic resins used in numerous industries since their discovery in the mid-19th century. Known for their versatility in formulating various consumer, health care, and industrial products, acrylates also have come under scrutiny for their potential to cause allergic contact dermatitis (ACD). Allergic contact dermatitis to acrylates previously was largely occupational in nature, but the expanded use of acrylates in products ranging from nail cosmetics to medical devices has increasingly brought this allergy to the general population. Herein, we discuss the chemistry and allergenicity of acrylates and highlight common sources of exposure, clinical presentations, pertinent considerations for patch testing, and tips for the management/prevention of acrylate ACD. We hope to emphasize the shifting trend of exposure sources from the workplace to consumers, underlining the need for increased vigilance from physicians. Collaborative efforts among health care providers and patient education about allergen avoidance strategies are essential to mitigate potential complications arising from acrylate sensitization.Cutis. 2023;112:282-286.• When patch testing for suspected acrylate allergy, 2-hydroxyethyl methacrylate (HEMA) is the most important screening allergen. Expanded testing to additional acrylates should be considered depending on the clinical scenario.

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Contact allergy to acrylates in Apple AirPods Pro® headphones: A case series

Cited by 6 publications

References 5 publications

Wireless over‐ear headphones: A new source of allergic contact dermatitis to isothiazolinones

Wireless over‐ear headphones: A new source of allergic contact dermatitis to isothiazolinones

Allergic contact dermatitis to in‐ear headphones occurring in the external ear

Tackling Acrylate Allergy: The Sticky Truth

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