Consumption of plant sterol-enriched foods and effects on plasma plant sterol concentrations – A meta-analysis of randomized controlled studies

Ras, Rouyanne T.; Hiemstra, Harry; Lin, Yuguang; Vermeer, Mario A.; Duchateau, Guus; Trautwein, Elke A.

doi:10.1016/j.atherosclerosis.2013.08.012

Cited by 91 publications

(72 citation statements)

References 70 publications

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“…The PS intake led to a significant reduction in total and LDL cholesterol concentrations, although the effect on LDL cholesterol was smaller (w7%) than anticipated (w12%) for the dose of PSs provided (3 g/d) (1,2). Plasma PS concentrations were significantly increased with PS intake as expected based on previous investigation (16).…”

Section: Discussionsupporting

confidence: 70%

The effect of a low-fat spread with added plant sterols on vascular function markers: Results of the investigating vascular function effects of plant sterols (invest) study

Ras¹,

Fuchs²,

Koppenol³

et al. 2015

Atherosclerosis

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Section: Discussionsupporting

confidence: 70%

The effect of a low-fat spread with added plant sterols on vascular function markers: Results of the investigating vascular function effects of plant sterols (invest) study

Ras¹,

Fuchs²,

Koppenol³

et al. 2015

Atherosclerosis

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“…Numerous clinical trials have shown that PS and their esters are effective in reducing circulating cholesterol levels in humans when included in a broad range of food matrices (Ras et al 2013), although the presence of nonresponders is well known (Izar et al 2011;Rideaout et al 2012;Weingartner et al 2014).…”

Section: Discussionmentioning

confidence: 99%

“…Different studies show that a daily intake of 1.6-2 g/day can reduce intestinal cholesterol absorption by about 30 % and plasma c-LDL levels by 8-10 % (Marangoni and Poli 2010;Ras et al 2013). However, due to emerging safety issues and the lack of results from trials testing relevant clinical endpoints, guidelines for PS remain controversial (Weingartner et al 2014).…”

Section: Introductionmentioning

confidence: 99%

β-Cryptoxanthin modulates the response to phytosterols in post-menopausal women carrying NPC1L1 L272L and ABCG8 A632 V polymorphisms: an exploratory study

et al. 2014

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Phytosterol (PS) intake may be used for hypercholesterolaemia in some groups although the presence of non-responders is well known. Carotenoids and PS/ cholesterol may compete for the same transporters during absorption. As part of a randomized, double-blind, crossover, multiple-dose supplementation study with b-cryptoxanthin (b-Cx) and PS, single and combined, polymorphisms of ABCG8 (A632V) and NCPL1 (L272L) were determined in 19 post-menopausal women. Subjects carrying CC polymorphism for NCP1L1 (L272L) showed a net increase in total cholesterol and LDL after PS intake but, interestingly, displayed a decrease in both lipid fractions after consuming PS plus b-Cx. For the ABCG8 (A632V) gene, CT/TT carriers consuming PS also displayed an increase in total cholesterol and LDL, but this increment was much lower after the intake of PS plus b-Cx. Additionally, in CC carriers for ABCG8 (A632V), a greater decrease in total cholesterol and LDL was found after the intake of PS plus b-Cx compared to that observed after PS alone. Overall, our results suggest that b-Cx improves the response to PS in individuals carrying specific genetic polymorphisms (i.e. non-responders), opening the possibility to modulate the response to PS by food technology. (ClinicalTrials.gov NCT01074723).

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“…Algunos metaanálisis (13)(14)(15)(16)(17) sostienen cómo el consumo de EV en alimentos enriquecidos reduce eficazmente las concentraciones en plasma de LDL-c y colesterol total (CT), manteniendo además los niveles de HDL-c.…”

Section: Introductionunclassified

Efecto de esteroles vegetales en la reducción del colesterol plasmático: ensayo clínico, controlado, aleatorizado, cruzado y doble ciego

et al. 2016

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Palabras clave:Colesterol. Riesgo cardiovascular. Esteroles vegetales. Lipoproteínas de baja densidad (LDL). Key words:Cholesterol. Cardiovascular risk. Plant sterols. Low density lipoproteins (LDL). AbstractIntroduction: Hypercholesterolemia is one of the most relevant risk factors in cardiovascular disease, and plant sterols have been postulated as benefi cial regulator agents for the control of the disease. Objective: Analyze the effect of added plant sterols in milk in reducing plasma cholesterol in young adults. Methods: A randomized, clinical controlled trial, double-blind crossover study. Sterols (2.24 g per day) were administrated in two doses of 350 ml of commercial skimmed milk, during two phases of three weeks respectively separated by a washout period of 2 weeks, in the experimental group. The same amount of skimmed milk was administrated to the control group, but with no sterols. At the beginning and end of each phase blood draws were performed. Anthropometric data and health habits were analyzed and the following blood laboratory markers: lipid profi le, hematology, infl ammation, etc. were collected. Results: Fifty four people were included in the study with an average age of 38.8 ± 7.3 years. Differences between baseline and fi nal scores percentage were 9.73 %, 12.5 %, 1.9 %, 3.15 % y 13.2 % for total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides and No HDL-cholesterol, respectively. Statistically signifi cant differences were found between the experimental group and the control group for all biomarkers analyzed except for triglycerides. Conclusion: Plant sterols supplied in commonly consumed food, such as milk, may be a non-pharmacological therapeutic strategy of hypercholesterolemia with high health interest.

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Consumption of plant sterol-enriched foods and effects on plasma plant sterol concentrations – A meta-analysis of randomized controlled studies

Abstract: Intake of PS-enriched foods increases plasma sitosterol and campesterol concentrations. However, total PS remain below 1% of total sterols circulating in the blood.

Cited by 91 publications

References 70 publications

The effect of a low-fat spread with added plant sterols on vascular function markers: Results of the investigating vascular function effects of plant sterols (invest) study

The effect of a low-fat spread with added plant sterols on vascular function markers: Results of the investigating vascular function effects of plant sterols (invest) study

β-Cryptoxanthin modulates the response to phytosterols in post-menopausal women carrying NPC1L1 L272L and ABCG8 A632 V polymorphisms: an exploratory study

Efecto de esteroles vegetales en la reducción del colesterol plasmático: ensayo clínico, controlado, aleatorizado, cruzado y doble ciego

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