Efecto de esteroles vegetales en la reducción del colesterol plasmático: ensayo clínico, controlado, aleatorizado, cruzado y doble ciego

Abstract

Palabras clave:Colesterol. Riesgo cardiovascular. Esteroles vegetales. Lipoproteínas de baja densidad (LDL). Key words:Cholesterol. Cardiovascular risk. Plant sterols. Low density lipoproteins (LDL). AbstractIntroduction: Hypercholesterolemia is one of the most relevant risk factors in cardiovascular disease, and plant sterols have been postulated as benefi cial regulator agents for the control of the disease. Objective: Analyze the effect of added plant sterols in milk in reducing plasma cholesterol in young adults. Methods: A randomized, clinical controlled trial, double-blind crossover study. Sterols (2.24 g per day) were administrated in two doses of 350 ml of commercial skimmed milk, during two phases of three weeks respectively separated by a washout period of 2 weeks, in the experimental group. The same amount of skimmed milk was administrated to the control group, but with no sterols. At the beginning and end of each phase blood draws were performed. Anthropometric data and health habits were analyzed and the following blood laboratory markers: lipid profi le, hematology, infl ammation, etc. were collected. Results: Fifty four people were included in the study with an average age of 38.8 ± 7.3 years. Differences between baseline and fi nal scores percentage were 9.73 %, 12.5 %, 1.9 %, 3.15 % y 13.2 % for total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides and No HDL-cholesterol, respectively. Statistically signifi cant differences were found between the experimental group and the control group for all biomarkers analyzed except for triglycerides. Conclusion: Plant sterols supplied in commonly consumed food, such as milk, may be a non-pharmacological therapeutic strategy of hypercholesterolemia with high health interest.

Efficacy of Hot Tea Infusion vs. Ethanolic Extract of Moringa oleifera for the Simultaneous Treatment of Nonalcoholic Fatty Liver, Hyperlipidemia, and Hyperglycemia in a Murine Model Fed with a High-Fat Diet

“…Similarly, another study using MO at a high concentration (15%) showed a lower degree of steatosis in animals fed an atherogenic diet. Finally, MO has been associated with hepatoprotective effects not only in response to the consumption of unbalanced diets but also in mitigating potential liver damage by drug-induced toxicity [ 66 , 67 ]. Despite the evidence of the positive effect of MO on hepatocytes, the mechanisms involved have not been fully elucidated.…”

Phytosterols in human health: friends or foes?

“…To further prove the significance of PS in cardiovascular diseases, clinical trials using PS in food have been tested. After a period of 3 weeks ingesting PS containing fat-free milk, healthy subjects reduced their LDL-and non-HDL-cholesterol (San Mauro-Martín et al, 2016).…”