Consumption of phenolic-rich jabuticaba (Myrciaria jaboticaba) powder ameliorates obesity-related disorders in mice

Abstract

Accumulating evidence indicates that dietary phenolic compounds can prevent obesity-related disorders. We investigated whether the consumption of polyphenol-rich jabuticaba peel and seed powder (JPSP) could ameliorates the progression of diet-induced obesity in mice. Male mice were fed a control diet or a high-fat (HF) diet for 9 weeks. After this period, mice were fed control, HF or HF diets supplemented with 5% (HF-J5), 10% (HF-J10) or 15% (HF-J15) of JPSP, for 4 additional weeks. Supplementation with JPSP not only attenuated HF-induced weight gain and fat accumulation but also ameliorated the pro-inflammatory response associated with obesity, as evidenced by the absence of mast cells in the visceral depot accompanied by lower IL-6 and TNF-α at the tissue and circulating levels. JPSP-supplemented mice also exhibited smaller-sized adipocytes, reduced levels of leptin and higher levels of adiponectin, concomitant with improved glucose metabolism and insulin sensitivity. The magnitude of the observed effects was dependent on JPSP concentration with HF-J10 and HF-J15-fed mice showing metabolic profiles similar to control. This study reveals that the consumption of JPSP protects against the dysfunction of the adipose tissue and metabolic disturbances in obese mice. Thus, these findings indicate the therapeutic potential of the phenolic-rich jabuticaba peel and seed powder in preventing obesity-related disorders.

Polyphenols—Gut Microbiota Interrelationship: A Transition to a New Generation of Prebiotics

“…It was observed that in rats with colon cancer that had been given jabuticaba yogurt, the diversity of Firmicutes , Bacteroidetes and Proteobacteria increased. In another study done in 2021, by Trindade et al [ 163 ], in diet-induced obese mice, the administration of polyphenol-rich jabuticaba peel and seed powder contributed to a decrease in weight gain fat accumulation, concomitant with an ameliorated proinflammatory response [ 162 , 163 ].…”

Brown Adipose Tissue, Batokines, and Bioactive Compounds in Foods: An Update

“…[ 117 ] Recent studies published by Trindade and collaborators showed that polyphenol‐rich jaboticaba ( Myrciaria jaboticaba ) at concentrations of 5%, 10%, and 15% w/w mitigated obesity, improved metabolic status, and increased expression of thermogenic markers (OPA‐1, PRDM‐16, PGC‐1α, PPAR‐γ, ADRB‐3, and UCP1) in the BAT of obese mice in a dose dependent‐manner. [ 118 ] In an in vitro model, brown adipocytes isolated from BAT were treated with black soybean extract (100, 200, and 400 µg mL −1 ) rich in the anthocyanins cyanidin‐3‐glucoside (C3G), delphinidin‐3‐glucoside (D3G), and petunidin‐3‐glucoside (P3G) and increased biomarkers of fatty acid degradation (phospho‐AMPKα and ATGL) and beta‐oxidation (CPT2) were observed. In addition, there was an increase in the expression of mitochondrial activation and thermogenesis markers (CIDEA, cytochrome c, NRF1, PGC‐1α, and UCP1) and in the rate of oxygen consumption and basal respiration, evidencing a greater metabolic activity of these adipocytes.…”

Obesity mechanisms and importance of bioactive compounds from fruits in its regulation – a narrative review

“…Two studies demonstrate the effects of supplemented jabuticaba peel and seed powder in mice fed a high-fat diet. Trindade et al (2021) concluded that supplementation attenuated weight gain and fat accumulation, absence of mast cells in the visceral depot, and reduction in circulating and tissue levels of IL-6 and TNF-α. Supplemented mice exhibited smaller adipocyte size, reduced leptin levels and increased adiponectin levels, as well as improved glucose metabolism and insulin sensitivity.…”