Consumption of kiwifruit capsules increases<i>Faecalibacterium prausnitzii</i>abundance in functionally constipated individuals: a randomised controlled human trial

Blatchford, Paul; Stoklosinski, Halina; Eady, Sarah L.; Wallace, Alison J.; Butts, Christine A.; Gearry, Richard B.; Gibson, Glenn R.; Ansell, Juliet

doi:10.1017/jns.2017.52

Cited by 36 publications

(34 citation statements)

References 47 publications

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“…A decrease in genus Faecalibacterium in patients with constipation has been previously reported. 67,68 Constipation increased family Lactobacillaceae, and COMT inhibitor intake had a more marked effect on this increase and masked the effect of constipation (Supporting Information Fig. S4).…”

Section: Discussionmentioning

confidence: 99%

Meta‐Analysis of Gut Dysbiosis in Parkinson's Disease

et al. 2020

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Background PD may begin with the intestinal accumulation of α‐synuclein fibrils, which can be causally associated with gut dysbiosis. The variability of gut microbiota across countries prevented us from identifying shared gut dysbiosis in PD. Objectives To identify gut dysbiosis in PD across countries. Methods We performed 16S ribosomal RNA gene sequencing analysis of gut microbiota in 223 patients with PD and 137 controls, and meta‐analyzed gut dysbiosis by combining our dataset with four previously reported data sets from the United States, Finland, Russia, and Germany. We excluded uncommon taxa from our analyses. For pathway analysis, we developed the Kyoto Encyclopedia of Genes and Genomes orthology set enrichment analysis method. Results After adjusting for confounding factors (body mass index, constipation, sex, age, and catechol‐O‐methyl transferase inhibitor), genera Akkermansia and Catabacter, as well as families Akkermansiaceae, were increased, whereas genera Roseburia, Faecalibacterium, and Lachnospiraceae ND3007 group were decreased in PD. Catechol‐O‐methyl transferase inhibitor intake markedly increased family Lactobacillaceae. Inspection of these bacteria in 12 datasets that were not included in the meta‐analysis revealed that increased genus Akkermansia and decreased genera Roseburia and Faecalibacterium were frequently observed across countries. Kyoto Encyclopedia of Genes and Genomes orthology set enrichment analysis revealed changes in short‐chain fatty acid metabolisms in our dataset. Conclusions We report that intestinal mucin layer‐degrading Akkermansia is increased and that short‐chain fatty acid–producing Roseburia and Faecalibacterium are decreased in PD across countries. © 2020 International Parkinson and Movement Disorder Society

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Section: Discussionmentioning

confidence: 99%

Meta‐Analysis of Gut Dysbiosis in Parkinson's Disease

et al. 2020

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“…These SCFAs generally have a beneficial effect on the gut and systemic health of the host [44]. For instance, Bifidobacterium helps to prevent pathogenic infection through the production of acetate [45], and Faecalibacterium prausnitzii , an important butyrate-producer, protects from inflammation in the gut [46]. However, several animal studies have demonstrated that dietary changes provide tremendous alterations in the compositions of the microbiota that leads to various illnesses [44,47,48,49].…”

Section: Interactions Between the Gut Microbiota And Dietary Nutrimentioning

confidence: 99%

“…It is unique and active commensal intestine bacterium and the representative of phylum— Firmicutes , class— Clostridium and family— Ruminococcaceae placed over 5% of the total gut microbiota population in the healthy human gut [203]. F. prausnitzii is a butyrate-producer and has well known the anti-inflammatory potential in the host [46]. Normally, butyrate gives energy for the host (5–15% of the total calories) that protects against pathogenic invasion, modulates the immune system and inhibits cancer progression [203], as well as autoimmune diabetes [204].…”

Section: F Prausnitzii Transplantation Improves Diabetesmentioning

confidence: 99%

“…High-fat diets supplemented with butyrate prevented insulin resistance in obese mice [195,215]. Remely et al [46] also reported a lower proportion of inflammatory markers found with F. prausnitzii in diabetic subjects, indicating a higher incidence of low-grade inflammation. An elevated level of butyrate is considered to inhibit the diet-induced obesity [216] and cause suppression of inflammatory reactions [199].…”

Section: F Prausnitzii Transplantation Improves Diabetesmentioning

confidence: 99%

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Causal Relationship between Diet-Induced Gut Microbiota Changes and Diabetes: A Novel Strategy to Transplant Faecalibacterium prausnitzii in Preventing Diabetes

Ganesan

Chung

Vanamala

et al. 2018

IJMS

160

116

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The incidence of metabolic disorders, including diabetes, has elevated exponentially during the last decades and enhanced the risk of a variety of complications, such as diabetes and cardiovascular diseases. In the present review, we have highlighted the new insights on the complex relationships between diet-induced modulation of gut microbiota and metabolic disorders, including diabetes. Literature from various library databases and electronic searches (ScienceDirect, PubMed, and Google Scholar) were randomly collected. There exists a complex relationship between diet and gut microbiota, which alters the energy balance, health impacts, and autoimmunity, further causes inflammation and metabolic dysfunction, including diabetes. Faecalibacterium prausnitzii is a butyrate-producing bacterium, which plays a vital role in diabetes. Transplantation of F. prausnitzii has been used as an intervention strategy to treat dysbiosis of the gut’s microbial community that is linked to the inflammation, which precedes autoimmune disease and diabetes. The review focuses on literature that highlights the benefits of the microbiota especially, the abundant of F. prausnitzii in protecting the gut microbiota pattern and its therapeutic potential against inflammation and diabetes.

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“…Fruits are another common source of plant-derived fibers. For example, complex pectins found in apples and wine can be degraded by Bacteroides thetaiotaomicron (B. thetaiotaomicron) (78), and kiwifruit supplements increased the abundance of Faecalibacterium prausnitzii (F. prausnitzii) in patients with constipation (79), while a crude extract of kiwi was shown to support the growth of Bifidobacterium and Bacteroides in vitro (80).…”

Section: Fibermentioning

confidence: 99%