Consumption of a high‐fat meal was associated with an increase in monocyte adhesion molecules, scavenger receptors, and Propensity to Form Foam Cells

Abstract

These results suggest that consumption of a high-fat meal increased the potential of monocytes to become foam cells, and implicates nonclassical monocytes as having greater potential than classical monocytes to become foam cells. © 2016 International Clinical Cytometry Society.

Oral spore-based probiotic supplementation was associated with reduced incidence of post-prandial dietary endotoxin, triglycerides, and disease risk biomarkers

“…These changes combined with a post-prandial increase in serum triglycerides creates a milieu that favors foam cell formation and the development of atherosclerotic plaques[ 19 , 31 , 33 , 34 ]. In the present study, the baseline post-prandial meal response presented outcomes that were consistent with published data from our laboratory and others[ 16 , 18 , 19 , 22 , 31 - 33 , 35 ]. Thus, the present study presented an opportunity to assess if a probiotic intervention would change disease risk biomarkers in a similar manner as endotoxin and triglycerides.…”

“…Previous authors consistently speculate that the onset and progression of chronic disease results from the accumulation of transient changes in ones’ health that result from lifestyle choices[ 16 , 18 , 19 , 22 , 28 , 30 - 32 ]. Unfortunately, the current literature has yet to define the quantity of transient change that must be accumulated to cause disease onset.…”

“…We have previously demonstrated that the consumption of a high-fat meal causes transient biological changes that were consistent with a transient increase in risk of atherosclerosis[ 16 , 18 , 21 , 32 ]. These changes combined with a post-prandial increase in serum triglycerides creates a milieu that favors foam cell formation and the development of atherosclerotic plaques[ 19 , 31 , 33 , 34 ].…”

“…Dietary endotoxemia transiently increases systemic inflammation, which chronically may increase one’s risk of a variety of diseases[ 2 ]. Our laboratory and others have demonstrated that consumption of a single, high-fat, high-calorie meal was associated with an increase in serum endotoxin, triglycerides, metabolic biomarkers, inflammatory cytokines, endothelial microparticles, and monocyte adhesion molecules[ 16 - 22 ]. The post-prandial time course varies for each biomarker, but generally the transient changes occur during the first five hours of the post-prandial period.…”

Issue Highlight – July 2018

“…The investigation from the group of North Texas University had the main scope to study the effects of a single high‐fat meal on monocyte adhesion molecule expression, CD36 expression and acLDL endocytosis using image‐based flow cytometry. Results showed that consumption of a high‐fat meal was associated with an increased adhesion molecules expression in both classical and non‐classical monocytes, scavenger receptors, and propensity to form foam cells .…”