Consumption of a Healthy Plant-based Diet is Associated With a Decreased Risk of Erectile Dysfunction: A Cross-sectional Study of the National Health and Nutrition Examination Survey

Carto, Chase; Pagalavan, Manjari; Nackeeran, Sirpi; Kresch, Eliyahu; Kuchakulla, Manish; Ramasamy, Ranjith

doi:10.1016/j.urology.2021.12.021

Cited by 10 publications

(7 citation statements)

References 24 publications

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“…To our knowledge, this is the first prospective study to evaluate the association between PDIs and incident ED. Our findings are consistent with cross-sectional evidence showing that higher hPDI reduces the risk of ED in men participating in the National Health and Nutrition Examination Survey and that fruit and vegetable intake is associated with lower prevalence of ED in diabetic men [6,7]. A case-control study also showed that men diagnosed with ED have lower PDI and hPDI scores [8].…”

Section: Discussionsupporting

confidence: 90%

“…[5] Because these diets encourage the preferential intake of fruit and vegetables over red meat, we hypothesized that plant‐based dietary patterns play a key role in these associations. While several cross‐sectional studies support this idea [6–8], a longitudinal analysis of prospectively collected data has not been performed to our knowledge.…”

Section: Introductionmentioning

confidence: 99%

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Plant‐based diet index and erectile dysfunction in the Health Professionals Follow‐Up Study

Yang¹,

Breyer²,

Rimm

et al. 2022

BJU International

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Objective To evaluate the longitudinal association between plant‐based diet index (PDI) score and incident erectile dysfunction (ED). Materials and Methods We conducted a prospective analysis of 21 942 men aged 40 to 75 years who were enrolled in the Health Professionals Follow‐Up Study. ED was assessed with questionnaires every 4 years starting in 2000. Dietary data were collected via validated food frequency questionnaires completed every 4 years and were used to calculate total PDI scores, as well as healthy (hPDI) and unhealthy (uPDI) subscores. Multivariable Cox proportional hazards models were used to compute hazard ratios (HRs) for incident ED. All models were stratified by age (<60, 60 to <70, ≥70 years). Results Among men aged 60 to <70 years, hPDI was inversely associated with incident ED. Those in the highest quintile of hPDI in that age group had an 18% lower risk of ED (HR 0.82, 95% confidence interval (CI) 0.73–0.91; P‐trend <0.001) compared to those in the lowest quintile. Conversely, uPDI was positively associated with ED in men aged <60 years (HR 1.27, 95% CI 1.01–1.60; P‐trend = 0.02). Conclusions Encouraging a healthy plant‐based diet may be an environmentally sustainable intervention for men interested in maintaining erectile function.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Plant‐based diet index and erectile dysfunction in the Health Professionals Follow‐Up Study

Yang¹,

Breyer²,

Rimm

et al. 2022

BJU International

View full text Add to dashboard Cite

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“…Several prospective cohort, cross‐sectional, and case–control human studies have been conducted to assess the association between dietary habits and EF, mainly assessed through the International Index of Erectile Function‐5 (IIEF‐5) questionnaire or a five‐point Likert scale (Table 1). Overall, a higher intake of fruits and/or vegetables was associated with lower odds of having or developing ED in most, 34–38 but not all studies 39,40 . Interestingly, a study conducted by Chen et al 41 .…”

Section: Resultsmentioning

confidence: 93%

Effects of diet and antihyperglycemic drugs on erectile dysfunction: A systematic review

et al. 2022

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Background: Erectile dysfunction is recognized as one of the complications of diabetes mellitus. To date, a wide gap of knowledge is present on the efficacy of pharmacological treatments of diabetes mellitus on erectile function, acting not only through metabolic control. Similarly, the effects of different diet regimens on erectile dysfunction are still debated. Objectives:We aimed to explore the effects of diet and antihyperglycemic drugs, considering both old and novel therapeutic approaches, on erectile function. Materials/methods:We performed a systematic review, following the PRISMA guidelines. The research was conducted on studies reporting erectile dysfunction assessment in subjects with diabetes and the relationship with diet and antihyperglycemic drugs. Results:The Mediterranean diet was effective in most studies for the protection of erectile function. Furthermore, antihyperglycemic drugs seem to show an overall protective role on erectile function.Discussion/conclusion: Although encouraging results are present for all classes of antihyperglycemic drugs, several studies are needed in humans, mainly on acarbose, pioglitazone, dipeptidyl-peptidase-4 inhibitors, and sodium-glucose cotransporter-2 inhibitors.

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“…Alcohol intake: Mean � SD, g/day 163 (21) 99 (14) 63 (10) 63 (10) 54 (7) 87 (12) 91 (13) 91 (15) 86 (12) 87 (12) Heart disease, no. (%)…”

Section: Resultsmentioning

confidence: 99%

Plant‐based diet associated with better quality of life in prostate cancer survivors

Loeb,

Hua,

Bauer

et al. 2024

Cancer

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BackgroundPlant‐based diets have many health benefits, including a lower risk of fatal prostate cancer, and greater environmental sustainability. However, less is known regarding the impact of plant‐based diets on quality of life among individuals diagnosed with prostate cancer. The authors' objective was to examine the relationship between plant‐based diet indices postdiagnosis with quality of life.MethodsThis prospective cohort study included 3505 participants in the Health Professionals Follow‐Up Study (1986–2016) with nonmetastatic prostate cancer. Food‐frequency questionnaires were used to calculate overall and healthful plant‐based diet indices. Quality‐of‐life scores were calculated using the Expanded Prostate Cancer Index Composite. Generalized estimating equations were used to examine associations over time between plant‐based diet indices and quality‐of‐life domains (sexual functioning, urinary irritation/obstruction, urinary incontinence, bowel functioning, hormonal/vitality), adjusted for demographics, oncologic history, body mass index, caloric intake, health‐related behaviors, and comorbidities.ResultsThe median age at prostate cancer diagnosis was 68 years; 48% of patients underwent radical prostatectomy, and 35% received radiation as primary therapy. The median time from diagnosis/treatment to first the quality‐of‐life questionnaire was 7.0 years. A higher plant‐based diet index was associated with better scores for sexual function, urinary irritation/obstruction, urinary incontinence, and hormonal/vitality. Consuming more healthful plant‐based foods was also associated with better sexual and bowel function, as well as urinary incontinence and hormonal/vitality scores in the age‐adjusted analysis, but not in the multivariable analysis.ConclusionsThis prospective study provides supportive evidence that greater consumption of healthful plant‐based foods is associated with modestly higher scores in quality‐of‐life domains among patients with prostate cancer.

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Consumption of a Healthy Plant-based Diet is Associated With a Decreased Risk of Erectile Dysfunction: A Cross-sectional Study of the National Health and Nutrition Examination Survey

Cited by 10 publications

References 24 publications

Plant‐based diet index and erectile dysfunction in the Health Professionals Follow‐Up Study

Plant‐based diet index and erectile dysfunction in the Health Professionals Follow‐Up Study

Effects of diet and antihyperglycemic drugs on erectile dysfunction: A systematic review

Plant‐based diet associated with better quality of life in prostate cancer survivors

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