Consumo de alcohol y tóxicos en pacientes con traumatismo craneoencefálico: repercusión neuroconductual y sobrecarga del cuidador

Castaño-Monsalve, Beatriz; Bernabeu-Guitart, Montserrat; López, Raquel; Bulbena-Vilarrasa, Antoni; Quemada, José Ignacio

doi:10.33588/rn.5607.2012412

Cited by 3 publications

(2 citation statements)

References 28 publications

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“…En la muestra estudiada, el índice de recaída fue de 18.4%, resultados similares a los reportados por otros investigadores, quienes han encontrado que entre 74.4 y 79% de los miembros de alcohólicos anónimos reportaban no haber consumido alcohol tras entrar al grupo 27,28 . Este hallazgo podría explicarse por el hecho de que la muestra formaba parte de AA, pues la probabilidad de recaer es menor en los adictos que completan un programa de rehabilitación 29 , encontrándose índices de recaída mucho mayores en otros estudios con alcohólicos que no habían participado en este tipo de programas 30 . Es necesario continuar explorando los factores protectores ofrecidos en AA que llevan a una alta efectividad del tratamiento y tomarlo de apoyo para fortalecer otros grupos terapéuticos y tratamientos.…”

Section: Discussionunclassified

Factores psicosociales en la recaída de la dependencia al alcohol: Un análisis de ruta

Torrealba¹,

Duin²,

Guerra³

et al. 2017

Enferm Inv

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Introducción: El consumo de alcohol causa alrededor del 6% de muertes a nivel mundial y se espera que el 70% de los pacientes en recuperación recaigan en los primeros seis meses de tratamiento. Esto, aunado a la aceptación social de esta sustancia y su fácil acceso, hacen necesario estudiar las variables asociadas a la recaída.Objetivo: Estudiar la influencia de variables sociodemográficas y psicosociales, sobre la recaída de la dependencia al alcohol.Métodos: Se realizó una investigación de campo, transversal y explicativa-correlacional, con la participación de 180 miembros de Alcohólicos Anónimos de Venezuela.Resultados: Participaron 87 mujeres y 93 hombres, con un promedio de 50 años. El índice de recaída fue de 18%, con un promedio de 130 meses de abstinencia. Se encontraron altos niveles de apoyo social, autoeficacia y autoestima, así como valores intermedios de estrés, impulsividad y resiliencia. Las variables estudiadas se asociaron con el tiempo en abstinencia (R = 0.615; p < 0.05) explicando el 35% de la varianza total. La edad (β = 0.57; p = 0.00), autoestima (β = -0.156; p = 0.02), apoyo social (β = 0.148; p = 0.02) y sexo (β = -0.135; p = 0.03) fueron las variables con mayor eficacia en la ruta principal.Conclusiones: El modelo propuesto se cumplió parcialmente. Es necesario profundizar el estudio de relaciones no planteadas entre las variables moderadoras, y si estas tienen otras que las modifiquen. Se recomienda enfatizar el abordaje de las variables que resultaron relevantes en la prevención de la recaída.

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Section: Discussionunclassified

Factores psicosociales en la recaída de la dependencia al alcohol: Un análisis de ruta

Torrealba¹,

Duin²,

Guerra³

et al. 2017

Enferm Inv

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“…A separate study showed that female mice (but not male mice) injured during adolescence self-administered more alcohol and showed increased alcohol Conditioned Place Preference (CPP) during adulthood compared to sham controls 22 . There is a need for studies examining sex differences in post-TBI alcohol drinking in preclinical models because there are sex differences in post-TBI alcohol use/misuse in humans 25 , and because preand post-TBI alcohol use can worsen TBI outcomes (e.g., increased risk of seizures, neuropsychiatric disorders, and subsequent TBIs) [26][27][28][29][30][31] .…”

Section: Introductionmentioning

confidence: 99%

JZL184 increases anxiety-like behavior and does not reduce alcohol consumption in female rats after repeated mild traumatic brain injury.

Jacotte-Simancas,

Molina,

Gilpin

2023

Preprint

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Alcohol use disorder (AUD) is highly comorbid with traumatic brain injury (TBI). Previously, using a lateral fluid percussion model (LFP) (an open model of head injury) to generate a single mild to moderate traumatic brain injury (TBI), we showed that TBI produces escalation in alcohol drinking, that alcohol exposure negatively impacts TBI outcomes, and that the endocannabinoid degradation inhibitor (JZL184) confers significant protection from behavioral and neuropathological outcomes in male rodents. In the present study, we used a weight drop model (a closed model of head injury) to produce a repeated mild TBI (rmTBI, 3 TBIs, spaced by 24 hours) to examine the sex-specific effects on alcohol consumption and anxiety-like behavior in rats, and whether systemic treatment with JZL184 would reverse TBI effects on those behaviors in both sexes. In two separate studies, adult male and female Wistar rats were subjected to rmTBI or sham using the weight drop model. Physiological measures of injury severity were collected from all animals. Animals in both studies were allowed to consume alcohol using an intermittent 2-bottle choice procedure (12 pre-TBI sessions and 12 post-TBI sessions). Neurological severity and neurobehavioral scores (NSS and NBS, respectively) were tested 24 hours after the final injury. Anxiety-like behavior was tested at 37-38 days post-injury in Study 1, and 6-8 days post-injury in Study 2. Our results show that females exhibited reduced respiratory rates relative to males with no significant differences between Sham and rmTBI, no effect of rmTBI or sex on righting reflex, and increased neurological deficits in rmTBI groups in both studies. In Study 1, rmTBI increased alcohol consumption in female but not male rats. Male rats consistently exhibited higher levels of anxiety-like behavior than females. rmTBI did not affect anxiety-like behavior 37-38 days post-injury. In Study 2, rmTBI once again increased alcohol consumption in female but not male rats, and repeated systemic treatment with JZL184 did not affect alcohol consumption. Also in Study 2, rmTBI increased anxiety-like behavior in males but not females and repeated systemic treatment with JZL184 produced an unexpected increase in anxiety-like behavior 6-8 days post-injury. In summary, rmTBI increased alcohol consumption in female rats, systemic JZL184 treatment did not alter alcohol consumption, and both rmTBI and sub-chronic systemic JZL184 treatment increased anxiety-like behavior 6-8 days post-injury in males but not females, highlighting robust sex differences in rmTBI effects.

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Risk Factors for Women Being Under the Influence of Alcohol Compared With Other Illicit Substances at the Time of Committing Violent Crimes

Brewer-Smyth

Pohlig²

2017

Journal of Forensic Nursing

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Consumo de alcohol y tóxicos en pacientes con traumatismo craneoencefálico: repercusión neuroconductual y sobrecarga del cuidador

Cited by 3 publications

References 28 publications

Factores psicosociales en la recaída de la dependencia al alcohol: Un análisis de ruta

Factores psicosociales en la recaída de la dependencia al alcohol: Un análisis de ruta

JZL184 increases anxiety-like behavior and does not reduce alcohol consumption in female rats after repeated mild traumatic brain injury.

Risk Factors for Women Being Under the Influence of Alcohol Compared With Other Illicit Substances at the Time of Committing Violent Crimes

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