Consuming egg yolk decreases body weight and increases serum HDL and brain expression of TrkB in male SD rats

Abstract

BACKGROUND Egg yolks contain large amounts of cholesterol and are suspected to be harmful after long‐term consumption. In this experiment, 63 rats were used to evaluate the effect of egg white (EW) and egg yolk (EY) supplementation on serum lipids and brain cognition. The feeding time lasted 4 weeks after a 1‐week acclimation. RESULTS Body weight was significantly higher in rats fed 132.0 g kg−1 EW and significantly lower when fed 40 g kg−1 EY (P < 0.05). Total cholesterol and low‐density lipoprotein increased in rats fed 72.0 g kg−1 EW compared with rats from NC and EY groups (P < 0.05). High‐density lipoprotein (HDL) was higher in rats fed 40 g kg−1 EY and decreased when fed 72.0 g kg−1 EW (P < 0.05). Rats fed a diet with EY exhibited abundant neurons in the CA1 hippocampus and complete subcellular structures. Rats fed 132 g kg−1 EW exhibited shrunken cells and swollen mitochondria. Brain‐derived neurotrophic factor had constitutively low expression among groups, while tyrosine kinase B (TrkB) exhibited higher expression levels in rats fed a diet containing EY compared with other groups (P < 0.05). CONCLUSION EY consumption reduced body weight and increased HDL levels. Diet containing EY could improve cognition through enhanced trkB expression. © 2019 Society of Chemical Industry

Early life exposure to hypercaloric diet impairs eating behavior during weaning: The role of BDNF signaling and astrocyte marks

“…The expressive upregulation (approximately 40%) of the TrkB receptor observed in hippocampi may reflect an adaptive compensatory response to diet‐induced downregulation of BDNF, similar to previous outcomes about stress (Nibuya et al, 1999). Taken that decreased BDNF has been related to eating behavior and energy expenditure (Chen et al, 2019; Marosi & Mattson, 2014; Noble et al., 2011), we can suggest a central role of brain BDNF in eating behavior impairments here observed. In accordance, hypothalamic infusions with BDNF can impact eating behavior and reduce overweight in mutant mice (Kernie et al.…”

“…Considering gestational exposure to HDs may alter hippocampal BDNF levels even in postnatal day (PND) 21, an usual time point for weaning (Richter et al, 2016), the relationship of central BDNF and framework of feeding pattern can bring clues about eating behavior changes induced by HD. In addition, taken that BDNF selectively activates tyrosine kinase receptor (TrkB), BDNF and TrkB can be evaluated in order to elucidate the BDNF function (Chen et al, 2019; Noble et al, 2011).…”

Whole egg consumption increases gene expression within the glutathione pathway in the liver of Zucker Diabetic Fatty rats

“…We previously demonstrated that WE consumption for 8 wk is effective at improving serum vitamin D status and providing nephroprotective benefits [ 17 , 18 ]; however, despite our gene expression findings in this study we still have yet to elucidate the mechanism underlying how WE consumption leads to decreased weight gain [ 28 , 29 ]. We also identified that ZDF rats fed WE upregulated 11 genes involved in glutathione metabolism in the liver and kidney.…”

Body Weight, Cholesterol Changes and Sub-Chronic Toxicity of Mice Treated with An Emulsion Product Rich in b-Carotene

“…Several research explained that the consumption of carotene and zeaxanthin derived from corn caused an increase in the expression of several genes. 15,16 The downstream effects that arise consist of changes in weight, energy and fat metabolism, regulation of apoptosis, and tumor suppression. In addition, consumption of these two active compounds also causes a decrease in gene expression of enzymes responsible for oxidative Table 6.…”