This article explores consumer, pharmacist, and physician perceptions of the issues affecting generic prescribing and dispensing of prescription drugs. The analysis is based on responses from 105 consumers, 118 pharmacists, and 412 physicians in Alabama. Perceptions regarding the issues of drug safety, efficacy, quality, manufacturer reputation, physician/pharmacist liability, and pricing and the roles of physicians and pharmacists in expanding generic practices were examined. Concerns about price, safety, liability, and manufacturer performance were expressed. The findings described are compared and contrasted with previous research.