2015
DOI: 10.3892/etm.2015.2262
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Construction of tissue-engineered laryngeal cartilage with a hollow, semi-flared shape using poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) as a scaffold

Abstract: The aim of the present study was to construct tissue-engineered laryngeal cartilage with a hollow, semi-flared shape using a poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHH) scaffold. Porous PHBHH was prepared and formed into a hollow, semi-flared shape, and the cell-material composites were cultured for one week in vitro prior to implantation in vivo. Cells of the nine rabbits of the experimental group were filled and encapsulated in the myofascial flap-shaping material composite for in situ implantation… Show more

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Cited by 12 publications
(7 citation statements)
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“…Heatmap representing the proportion of publications by year that utilized specific translational research methodologies from construct characterization to human trial to investigate laryngeal tissue engineering 85‐87,91,92,94,96,97,198‐306 …”
Section: Discussionmentioning
confidence: 99%
“…Heatmap representing the proportion of publications by year that utilized specific translational research methodologies from construct characterization to human trial to investigate laryngeal tissue engineering 85‐87,91,92,94,96,97,198‐306 …”
Section: Discussionmentioning
confidence: 99%
“…During our studies we also noted a plateau at around 86% porosity which we attribute to limitations in the inherent packing properties of the NaHCO 3 particles [ 69 , 70 ]. Porosity in scaffolds is an essential feature for guiding cell migration and creating a three-dimensional tissue for laryngeal applications [ 71 ]. Here we note that there is a clear shift in the pore size distribution with the size of the pores increasing as the porogen concentration is increased.…”
Section: Discussionmentioning
confidence: 99%
“…The morphology of the implant was shaped according to the anatomy of an adult laryngeal cartilage, as can been seen in Figure 11 a. First, chondrocytes were inoculated onto the PHBH scaffold, and after one week of in vitro culture, an in vivo implantation was performed and the results showed that cartilage formed six weeks after the surgery ( Figure 11 b) [ 154 ].…”
Section: Different Biomedical Applications: From Conventional To Imentioning
confidence: 99%
“… Experimental PHAs applications for cartilage tissue engineering. ( a ) Representation of a PHBH medical device prepared by solvent casting, compression molding, and particulate filtering, with a final hollow semi-flared shape, which intends to mimic the laryngeal cartilage morphology (adapted from Reference [ 154 ]). ( b ) Photograph of the laryngeal cartilage PHBH specimen with chondrocytes inoculated, 18 weeks after implantation (adapted from Reference [ 154 ]).…”
Section: Figurementioning
confidence: 99%