Construction of Tb-MOF-on-Fe-MOF conjugate as a novel platform for ultrasensitive detection of carbohydrate antigen 125 and living cancer cells

Wang, Minghua; Hu, Mengyao; Li, Zhenzhen; He, Linghao; Song, Yingpan; Jia, Qiaojuan; Du, Miao

doi:10.1016/j.bios.2019.111536

Cited by 164 publications

(50 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another technique is based on the increase in charge transfer resistance via the impedance technique [174]. Therefore, an electrochemical aptasensor was provided for the detection of several targets, such as ampicillin (AMP), avian influenza virus (H5N1), carbohydrate antigen 125, Pb 2+ , lysozymes, insulin, thrombin, CD44, vanillin, circulating human MDA-MB-231 breast cancer cells, bisphenol A, furaneol, and Hg 2+ , among others [8,46,[175][176][177][178][179][180][181][182][183][184][185][186][187][188][189].…”

Section: Electrochemical Aptasensormentioning

confidence: 99%

Recent Advances in Aptamer Sensors

Shaban

Kim

2021

Sensors

View full text Add to dashboard Cite

Recently, aptamers have attracted attention in the biosensing field as signal recognition elements because of their high binding affinity toward specific targets such as proteins, cells, small molecules, and even metal ions, antibodies for which are difficult to obtain. Aptamers are single oligonucleotides generated by in vitro selection mechanisms via the systematic evolution of ligand exponential enrichment (SELEX) process. In addition to their high binding affinity, aptamers can be easily functionalized and engineered, providing several signaling modes such as colorimetric, fluorometric, and electrochemical, in what are known as aptasensors. In this review, recent advances in aptasensors as powerful biosensor probes that could be used in different fields, including environmental monitoring, clinical diagnosis, and drug monitoring, are described. Advances in aptamer-based colorimetric, fluorometric, and electrochemical aptasensing with their advantages and disadvantages are summarized and critically discussed. Additionally, future prospects are pointed out to facilitate the development of aptasensor technology for different targets.

show abstract

Section: Electrochemical Aptasensormentioning

confidence: 99%

Recent Advances in Aptamer Sensors

Shaban

Kim

2021

Sensors

View full text Add to dashboard Cite

show abstract

“…X-ray photoelectron spectroscopy (XPS) is a powerful tool to investigate the chemical composition of sensing materials. 33,34 Fig. 2A is the XPS survey spectrum for Co-MOF, which veries that the Co-MOF contained Co, O, N and C elements.…”

Section: X-ray Photoelectron Spectroscopy Characterization Of Co-mofmentioning

confidence: 99%

Cytochrome c-multiwalled carbon nanotube and cobalt metal organic framework/gold nanoparticle immobilized electrochemical biosensor for nitrite detection

2021

View full text Add to dashboard Cite

show abstract

“…MOFs are applicable as a suitable platform for sensing because of the multiple grafting groups (e.g., NH 2 or COOH), π–π stacking, hydrogen bonding, and electrostatic interactions with negatively charged nucleic acid sequences. [ 124-126 ] Especially, MOFs show outstanding stability, biocompatibility, redox activity, and good sensing performances. Therefore, investigating new type of MOF‐based biosensors is imperative for timely clinical diagnosis and treatment for diseases.…”

Section: Applicationsmentioning

confidence: 99%

“…Also, Zn‐MOF‐on‐Zr‐MOF‐based aptasensor exhibited good stability, with no apparent change in response to 0.001 and 1 ng mL −1 PTK7 for 15 d. Considering the good sensing performances of Fe‐MOF and excellent fluorescence property of Tb‐MOF, [ 131,132 ] Wang et al constructed bimetallic TbFe‐based MOF as the platform to anchor carbohydrate antigen 125 (CA125) aptamer for the detection of CA125 and living michigan cancer foundation‐7 (MCF‐7) cells. [ 126 ] The Tb‐MOF‐on‐Fe‐MOF‐based aptasensor on MCF‐7 cells was stable for 15 days. For the detection of 500 cells mL −1 using the same aptasensor mode, the final electrochemical impedance spectroscopy response was 97.7% of the initial response, implying its strong stability.…”

Section: Applicationsmentioning

confidence: 99%

Metal–Organic Framework‐Based Hybrid Frameworks

et al. 2020

View full text Add to dashboard Cite

Framework materials, such as metal–organic frameworks (MOFs) and covalent organic frameworks (COFs), offer huge potential for applications in many aspects due to their well‐defined topologies, high crystallinity, inherent porosity, and chemical tunability. One advanced concept of further functionalizing the single framework materials is to construct hybrid frameworks (e.g., MOF‐on‐MOF, MOF‐on‐COF, and COF‐on‐MOF). Herein, different MOF‐based hybrid frameworks with complex compositions and well‐designed structures show excellent properties that cannot be achieved by single framework materials. The synthetic approaches of MOF‐based hybrid frameworks and their related applications are summarized. The opportunities and challenges for MOF‐based hybrid frameworks are also discussed.

show abstract

Construction of Tb-MOF-on-Fe-MOF conjugate as a novel platform for ultrasensitive detection of carbohydrate antigen 125 and living cancer cells

Cited by 164 publications

References 67 publications

Recent Advances in Aptamer Sensors

Recent Advances in Aptamer Sensors

Cytochrome c-multiwalled carbon nanotube and cobalt metal organic framework/gold nanoparticle immobilized electrochemical biosensor for nitrite detection

Metal–Organic Framework‐Based Hybrid Frameworks

Contact Info

Product

Resources

About