Cytochrome c-multiwalled carbon nanotube and cobalt metal organic framework/gold nanoparticle immobilized electrochemical biosensor for nitrite detection

Abstract

Based on cytochrome c-multiwalled carbon nanotubes (Cyt c-MWCNTs) and cobalt metal organic frameworks/gold nanoparticles (Co-MOFs/AuNPs), an electrochemical biosensor was proposed for the detection of nitrite.

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“…Similarly, GNPs-decorated Ce-MOF were developed for the ratiometric detection of telomerase activity [ 130 ]. Huang et al developed an amine functionalized Co-MOF decorated with GNPs for the immobilization of Cyt-c-modified MWCNT and fabricated a nitrite biosensor [ 131 ]. Here, the Co-MOF provided ample surface area to decorate the GNPs and immobilize Cyt-c/MWCNT.…”

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“…Similarly, like the other analytes reported here in our review of the literature, nitrites are also used in the food industry extensively. 58 a , b Excessive consumption of nitrites causes generation of carcinogens, blue baby syndrome and birth defects. 58 c , d Cytochrome c acts as an oxidoreductase enzyme and electron transfer agent.…”

“…58 a , b Excessive consumption of nitrites causes generation of carcinogens, blue baby syndrome and birth defects. 58 c , d Cytochrome c acts as an oxidoreductase enzyme and electron transfer agent. 58 e Although researchers found interest in Cyt c for sensing nitrite, the use of Cyt c in directly modified electrode surfaces causes many problems, such as loss of enzymatic activity, etc.…”

“…58 c , d Cytochrome c acts as an oxidoreductase enzyme and electron transfer agent. 58 e Although researchers found interest in Cyt c for sensing nitrite, the use of Cyt c in directly modified electrode surfaces causes many problems, such as loss of enzymatic activity, etc. In 2021, an electrochemical biosensor was reported by Huang et al for detection of nitrite.…”

“…In 2021, an electrochemical biosensor was reported by Huang et al for detection of nitrite. 58 e Herein, the proposed biosensor was based on cytochrome c -multiwalled carbon nanotubes, cobalt metal–organic frameworks and gold nanoparticles. At first, AuNPs were electrodeposited on a Co-MOF-modified GCE and then the Cyt c -MWCNTs were immobilized on the modified electrode (Fig.…”