Construction of New Coated Carbon Electrodes for Determination of Sildenafil Citrate Drug

Abstract

In this research, new coated carbon electrodes were constructed and used for the determination of Sildenafil citrate (SILC) drug. The electrodes were constructed by preparing ion-pair for (SILC) with phosphotungstic acid (PTA) or phosphomolybdic (PMA) acid using dibutyl phthalate (DBP) as a plasticizer. These electrodes showed good sensitivity towards SILC with linear range of (1.010-7-1.010-2) M, correlation coefficient, (0.9990), the life time (120) days, optimum temperature range (23-65) o C and optimum pH range (2-5) for both electrodes, limit of detection (5.05510-8 and 5.11610-8) M, slope (57.29 and 59.10) mV/decadefor SILC-PTA and SILC-PMA electrodes respectively. These electrodes were successfully applied for determination of SILC in pure and pharmaceutical preparation form(tablets) with recovery of not less than 98%.

Fabrication of Coupling Approach between Flow Injection System – Ion Selective Electrode

“…the simultaneous physical and chemical processes, Understanding the theoretical underpinnings of FIA is essential to improving system design performance. [8] A sample that has been introduced into a transport flow traveling via a brief rectangular channel segment, or both, are present at the beginning; The obstruction disperses and combines with the mobile phase as it moves upstream; a pronounced concentration gradient, forms, In the event where turbulence is to blame for; the sample dispersion, the flow profile exhibits a hyperbolic head and tail. This kind of flow, which is characteristic, of most FIA systems, is known, as laminar flow; a limitless The liquid in a flowing stream can have a variety of velocity profiles, with the highest velocity being observed in the middle of the torrent.…”