Construction of Magnetic Nanochains to Achieve Magnetic Energy Coupling in Scaffold

Shuai, Cijun; Chen, Xuan; He, Chongxian; Qian, Guowen; Shuai, Yang; Yao, Jia; Xu, Wendi; Peng, Shuping; Deng, Youwen; Yang, Wenjing

doi:10.21203/rs.3.rs-1448231/v1

Cited by 7 publications

(2 citation statements)

References 51 publications

(54 reference statements)

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“…The cells on all the extracts exhibited spherical morphologies on the first day. After 3 days, the cells in Fe–CuO showed more spindle-shaped cell morphologies with green fluorescence than those in Fe and Fe–Cu groups, implying cell membrane integrity. , Moreover, the cells on Fe–CuO showed a more spread morphology with many filopodia and lamellipodia. , It could be deduced that the Fe–CuO composite was more favorable to cell spreading.…”

Section: Resultsmentioning

confidence: 99%

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Highly Dispersed Cu Produced by Mechanical Stress-Activated Redox Reaction to Establish Galvanic Corrosion in Fe Implant

Zeng

Yang

et al. 2022

ACS Biomater. Sci. Eng.

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Fe has immense potential for biodegradable orthopedic applications, but it degrades slowly in the physiological environment. Inducing galvanic couple by alloying Cu to Fe using ball milling is a promising approach. However, the ductile nature of Cu leads to the cold welding of a large amount of Cu powder during ball milling, which makes it difficult to disperse uniformly in the Fe matrix. Here, a Fe−CuO implant with highly dispersed Cu particles in the matrix was developed by shift-speed ball milling and selective laser melting. Specifically, copper oxide (CuO) particles were selected as precursors and dispersed in Fe powders by ball milling since they were brittle and would not be cold-welded during ball milling. After further milling in higher energy, it was found that CuO particles reacted with Fe and generated Cu particles through a stress-activated redox reaction. Subsequently, the obtained powders were prepared into a Fe−CuO implant using selective laser melting. Microstructure examination revealed that the Cu phases in the implant were dispersed evenly in the Fe matrix, which was considered to establish a large number of galvanic couples and aggravated the galvanic corrosion tendency. Electrochemical tests indicated that the implant had improved performance in degradation behavior in terms of high corrosion current density (22.4 μA/cm 2 ), low corrosion resistance (1319 Ω cm 2 ), and good degradation stability. In addition, it presented antibacterial effects against Escherichia coli and Staphylococcus aureus by diffusion mechanisms with killing rates of 90.7 and 96.7%, respectively, as well as good cytocompatibility.

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Section: Resultsmentioning

confidence: 99%

“…48,49 Moreover, the cells on Fe−CuO showed a more spread morphology with many filopodia and lamellipodia. 50,51 It could be deduced that the Fe−CuO composite was more favorable to cell spreading.…”

Section: Cytocompatibility Evaluationmentioning

confidence: 99%